{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:05:12Z","timestamp":1789992312270,"version":"4.0.1"},"reference-count":33,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["LIFE16 ENV\/ES\/000169"],"award-info":[{"award-number":["LIFE16 ENV\/ES\/000169"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"award":["LIFE16 ENV\/ES\/000169"],"award-info":[{"award-number":["LIFE16 ENV\/ES\/000169"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Translating adsorption performance from batch experiments to continuous-flow operation is a key step toward practical water-treatment applications. In this study, a laboratory-scale continuous adsorption system based on a water-insoluble \u03b2-cyclodextrin-epichlorohydrin (\u03b2-CD-EPI) polymer was validated from hydrodynamic, adsorptive, and operational perspectives. Downflow operation caused progressive bed compaction and excessive pressure development, whereas a 90 mm column operated in upflow mobile-bed mode, with visually observed bed expansion, showed comparatively stable pressure-drop behavior at superficial linear velocities below approximately 12 m h\u22121. Under these controlled high-loading conditions, removal was strongly contaminant-dependent: cyproconazole exceeded 90%, acetaminophen reached 72\u201377%, hydrochlorothiazide reached 40\u201365%, ciprofloxacin reached 24\u201350%, and furosemide remained below 30%. The relative performance for furosemide and hydrochlorothiazide differed from that predicted by previous batch-derived adsorption parameters, demonstrating that batch results cannot be directly extrapolated to dynamic operation. Competitive adsorption in binary and ternary mixtures reduced contaminant removal, while cyproconazole removal decreased from &gt;90% in tap water to 48\u201355% in secondary-treated wastewater, demonstrating the relevance of the aqueous matrix under the tested continuous-flow conditions. Operational screening tests showed that desorption with 220 mM acetate buffer at pH 4.0 recovered &gt;80% of the retained cyproconazole within 10 min in the tested sequence, followed by a two-stage rinse that restored the operational pH. These preliminary conditions require confirmation through replicated adsorption\u2013desorption cycles under continuous-flow operation. These results identify laboratory-scale hydrodynamic, adsorption, matrix, and regeneration considerations that require confirmation through fixed-condition, long-term testing during subsequent process development.<\/jats:p>","DOI":"10.3390\/polym18182292","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:05:53Z","timestamp":1789988753000},"page":"2292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Batch-to-Flow Translation of \u03b2-Cyclodextrin Polymer Adsorption for Emerging Contaminant Removal: Hydrodynamic and Operational Validation"],"prefix":"10.3390","volume":"18","author":[{"given":"Antonio Tom\u00e1s Hern\u00e1ndez","family":"Cegarra","sequence":"first","affiliation":[{"name":"Molecular Recognition and Encapsulation Research Group (REM), Health Sciences Department, Universidad Cat\u00f3lica de Murcia (UCAM), Campus de los Jer\u00f3nimos 135, E-30107 Guadalupe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"G\u00f3mez-Morte","sequence":"additional","affiliation":[{"name":"Molecular Recognition and Encapsulation Research Group (REM), Health Sciences Department, Universidad Cat\u00f3lica de Murcia (UCAM), Campus de los Jer\u00f3nimos 135, E-30107 Guadalupe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Pellicer","sequence":"additional","affiliation":[{"name":"Molecular Recognition and Encapsulation Research Group (REM), Health Sciences Department, Universidad Cat\u00f3lica de Murcia (UCAM), Campus de los Jer\u00f3nimos 135, E-30107 Guadalupe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-4950","authenticated-orcid":false,"given":"Mar\u00eda Isabel","family":"Rodr\u00edguez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Molecular Recognition and Encapsulation Research Group (REM), Health Sciences Department, Universidad Cat\u00f3lica de Murcia (UCAM), Campus de los Jer\u00f3nimos 135, E-30107 Guadalupe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9825-3326","authenticated-orcid":false,"given":"Nuria","family":"Vela","sequence":"additional","affiliation":[{"name":"Applied Technology Group to Environmental Health, Universidad Cat\u00f3lica de Murcia (UCAM), Campus de los Jer\u00f3nimos 135, E-30107 Guadalupe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7646-0386","authenticated-orcid":false,"given":"\u00c1ngel","family":"Gil-Izquierdo","sequence":"additional","affiliation":[{"name":"Research Group on Quality, Safety, and Bioactivity of Plant-Derived Foods, Department of Food Science and Technology, Centro de Edafolog\u00eda y Biolog\u00eda Aplicada del Segura\u2013Consejo Superior de Investigaciones Cient\u00edficas (CEBAS-CSIC), Campus de Espinardo 25, E-30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-2365","authenticated-orcid":false,"given":"Estrella","family":"N\u00fa\u00f1ez-Delicado","sequence":"additional","affiliation":[{"name":"Molecular Recognition and Encapsulation Research Group (REM), Health Sciences Department, Universidad Cat\u00f3lica de Murcia (UCAM), Campus de los Jer\u00f3nimos 135, E-30107 Guadalupe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-2920","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Gabald\u00f3n","sequence":"additional","affiliation":[{"name":"Molecular Recognition and Encapsulation Research Group (REM), Health Sciences Department, Universidad Cat\u00f3lica de Murcia (UCAM), Campus de los Jer\u00f3nimos 135, E-30107 Guadalupe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175664","DOI":"10.1016\/j.scitotenv.2024.175664","article-title":"Occurrence and distribution of emerging contaminants in wastewater treatment plants: A globally review over the past two decades","volume":"951","author":"Jiang","year":"2024","journal-title":"Sci. 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