{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:06:37Z","timestamp":1790053597948,"version":"4.0.1"},"reference-count":63,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Project of Guizhou Province","award":["Qiankehe Jichu-MS [2025] 529"],"award-info":[{"award-number":["Qiankehe Jichu-MS [2025] 529"]}]},{"name":"Science and Technology Foundation of the Guizhou Provincial Health Commission","award":["gzwkj2026-125"],"award-info":[{"award-number":["gzwkj2026-125"]}],"id":[{"id":"https:\/\/ror.org\/027yzwq33","id-type":"ROR","asserted-by":"crossref"}]},{"award":["gzwkj2026-125"],"award-info":[{"award-number":["gzwkj2026-125"]}],"id":[{"id":"https:\/\/ror.org\/027yzwq33","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Xylan sulfates are established anticoagulant polysaccharides, but their preparation requires balancing sulfate substitution and product recovery. Sugarcane-bagasse xylan was sulfated using sulfur trioxide\u2013pyridine complex (SO3\u00b7Py), 4-dimethylaminopyridine (DMAP), and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI). An entropy-weighted five-factor Box\u2013Behnken design jointly optimized degree of substitution (DS) and isolated, DS-adjusted yield, assigning respective weights of 0.570 and 0.430. Pareto analysis identified a trade-off between increasing DS and decreasing yield, while accounting for model uncertainty produced little change in the selected optimum. Validation used adjusted reagent-to-xylan mass ratios of 0.2, 3.2, and 2.2 g\/g for DMAP, SO3\u00b7Py, and EDCI, respectively, at 50.7 \u00b0C for 3.8 h. Three independent batches yielded DS = 1.53 \u00b1 0.01, yield = 78.0 \u00b1 0.1%, and a composite score of 0.792 \u00b1 0.008, within the model\u2019s 95% prediction interval. Operational water solubility increased from 21.2 to 96.8\u2013130.4 mg\/mL after sulfation, alongside changes in aqueous aggregation and rheology. In citrated sheep plasma, the derivatives prolonged activated partial thromboplastin time and thrombin time with increasing concentration. Responses increased across the derivative series, in which DS and the reported apparent molar mass covaried. These results provide a basis for balancing substitution and product recovery and comparing the water solubility and in vitro anticoagulant responses of the resulting derivatives.<\/jats:p>","DOI":"10.3390\/polym18182296","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:05:53Z","timestamp":1789988753000},"page":"2296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sulfation of Sugarcane-Bagasse Xylan: Process Optimization, Physicochemical Properties and In Vitro Anticoagulant Activity"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9938-9515","authenticated-orcid":false,"given":"Mingjun","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Guizhou Medical University, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Light Industry and Food Engineering, Guangxi University, Provincial and Ministerial Collaborative Innovation Center for the Sugar Industry, Engineering Research Center for the Sugar Industry and Comprehensive Utilization, Ministry of Education, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, School of Basic Medicine, Guizhou Medical University, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Light Industry and Food Engineering, Guangxi University, Provincial and Ministerial Collaborative Innovation Center for the Sugar Industry, Engineering Research Center for the Sugar Industry and Comprehensive Utilization, Ministry of Education, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1039\/D5FB00624D","article-title":"Effective valorisation of cereal lignocellulosic waste: A review of pretreatment techniques to enhance microstructural modification","volume":"4","author":"Ale","year":"2026","journal-title":"Sustain. 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