{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:43:45Z","timestamp":1760060625901,"version":"build-2065373602"},"reference-count":66,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCYT REGULAR","award":["1210349","21201557"],"award-info":[{"award-number":["1210349","21201557"]}]},{"name":"ANID","award":["1210349","21201557"],"award-info":[{"award-number":["1210349","21201557"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proteomes"],"abstract":"<jats:p>Background: Endometrosis is a prevalent fibrotic condition in mares that impairs reproductive efficiency by inducing transdifferentiation of endometrial stromal cells into myofibroblasts, leading to excessive ECM deposition. Methods: To elucidate the molecular mechanisms underlying fibrosis resolution, this study employed comprehensive proteomic techniques, including LC-MS\/MS and SILAC, to analyze the interaction between myofibroblasts and mesenchymal stem cells derived from the endometrium (ET-eMSCs) preconditioned with PGE2. An in vitro co-culture system was used, with samples collected at baseline and after 48 h. Results: Proteomic analysis identified significant alterations in proteins associated with ECM remodeling, immune regulation, and cellular stress response. Notably, proteins involved in collagen degradation, antioxidant defense, and growth factor signaling pathways were differentially abundant. Network analyses demonstrated robust interactions among these proteins, suggesting coordinated modulatory effects. The data indicate that PGE2-primed ET-eMSCs induce a shift in myofibroblast secretory profiles, promoting a reduction in ECM stiffness, tissue reorganization, and activation of resolution pathways. Data are available via ProteomeXchange with identifier PXD067551. Conclusions: These findings reinforce the therapeutic potential of mesenchymal stem cell-based interventions for fibrotic diseases of the endometrium, opening avenues for regenerative strategies to restore reproductive function in mares.<\/jats:p>","DOI":"10.3390\/proteomes13030041","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T11:51:12Z","timestamp":1757332272000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bidirectional Interaction Between PGE2-Preconditioned Mesenchymal Stem Cells and Myofibroblasts Mediates Anti-Fibrotic Effects: A Proteomic Investigation into Equine Endometrial Fibrosis Reversal"],"prefix":"10.3390","volume":"13","author":[{"given":"Lidice","family":"M\u00e9ndez-P\u00e9rez","sequence":"first","affiliation":[{"name":"Laboratory of Animal Biotechnology, Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepci\u00f3n, Chill\u00e1n 3780000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-6325","authenticated-orcid":false,"given":"Yat Sen","family":"Wong","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Biotechnology, Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepci\u00f3n, Chill\u00e1n 3780000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n O.","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Biotechnology, Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepci\u00f3n, Chill\u00e1n 3780000, Chile"},{"name":"Vascular Physiology Laboratory, Group of Research and Innovation in Vascular Health, Basic Sciences Department, Faculty of Sciences, Universidad del Bio-Bio, Chill\u00e1n 378000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-2852","authenticated-orcid":false,"given":"Ioanna","family":"Martinez-Hormaza","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Biotechnology, Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepci\u00f3n, Chill\u00e1n 3780000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-1097","authenticated-orcid":false,"given":"Lleretny","family":"Rodr\u00edguez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Biotechnology, Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepci\u00f3n, Chill\u00e1n 3780000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8828-1449","authenticated-orcid":false,"given":"Fidel Ovidio","family":"Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Biotechnology, Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepci\u00f3n, Chill\u00e1n 3780000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"ref_1","unstructured":"Trundell, D.A. 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