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In the intestines, egg secretions drive inflammatory processes involved in extravasation to the gut lumen. Methods: Here, we investigate parasite-host interactions in a mouse model during the acute phase of a patent infection at 5 and 7 weeks, using parallel histological and proteomic analysis of paraffin-embedded ileal tissues. Results: Histology at week 7 showed infected animals had more inflammation and longer villi than at week 5, as well as more Goblet cells reflecting enhanced mucus production. LC-MS\/MS analysis of deparaffinized ileal sections, subjected to in-solution tryptic digestion, revealed a total of 1615 protein groups. Differentially abundant proteins were found early at week 5, coinciding with the onset of egg deposition. A contrasting scenario, dominated by upregulation of protein components from the innate and adaptive immune systems, was seen at week 7; at this point, egg migration and excretion are underway. Among the proteins were mast cell proteases, fibrinogens, arginase-1, and molecules associated with extracellular matrix remodeling. Conclusions: Our findings reflect intestinal proteome changes likely participating in S. mansoni egg passage from the vascular bed to the intestinal lumen.<\/jats:p>","DOI":"10.3390\/proteomes14030039","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:45:14Z","timestamp":1785325514000},"page":"39","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic Analysis of Paraffin-Embedded Intestines from Schistosoma mansoni Infection in Mice: Highlighting Molecular Players During Acute Schistosomiasis"],"prefix":"10.3390","volume":"14","author":[{"given":"Lara Geralda Magela dos Santos","family":"Vieira","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas, N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Universidade Federal de Ouro Preto, Ouro Preto 35402-136, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via Pinho","family":"Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas, N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Universidade Federal de Ouro Preto, Ouro Preto 35402-136, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo Elber","family":"Vital","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Universidade Federal de Ouro Preto, Ouro Preto 35402-136, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-1512","authenticated-orcid":false,"given":"D\u00e1vila Regina Pacheco","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia, N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Universidade Federal de Ouro Preto, Ouro Preto 35402-136, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via de Souza","family":"Marques","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas, N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Universidade Federal de Ouro Preto, Ouro Preto 35402-136, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Gon\u00e7alves","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas, N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Universidade Federal de Ouro Preto, Ouro Preto 35402-136, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-7686","authenticated-orcid":false,"given":"Paula Melo de Abreu","family":"Vieira","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Universidade Federal de Ouro Preto, Ouro Preto 35402-136, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-0321","authenticated-orcid":false,"given":"R Alan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Biology, York Biomedical Research Institute, University of York, York YO10 5DD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Castro-Borges","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas, Universidade Federal de Ouro Preto, Ouro Preto 35402-136, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022). 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