{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:22:56Z","timestamp":1761744176789,"version":"build-2065373602"},"reference-count":69,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Aeronautics and Space Administration (NASA)","award":["NNX11AK91G"],"award-info":[{"award-number":["NNX11AK91G"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proteomes"],"abstract":"<jats:p>Myeloid leukemia (ML) is one of the major health concerns from exposure to radiation. However, the risk assessment for developing ML after exposure to space radiation remains uncertain. To reduce the uncertainty in risk prediction for ML, a much increased understanding of space radiation-induced changes in the target cells, i.e., hematopoietic stem\/progenitor cells (HSPCs), is critically important. We used the label-free quantitative mass spectrometry (LFQMS) proteomic approach to determine the expression of protein in HSPC-derived myeloid colonies obtained at an early time-point (one week) and a late time-point (six months) after an acute whole body exposure of CBA\/CaJ mice to a total dose of 0, 0.1, 0.25, or 0.5 Gy of heavy-ion titanium (48Ti ions), which are the important component of radiation found in the space environment. Mice exposed to 0 Gy of 48Ti ions served as non-irradiated sham controls. There were five mice per treatment groups at each harvest time. The Trans-Proteomic Pipeline (TPP) was used to assign a probability of a particular protein being in the sample. A proof-of-concept based Ingenuity Pathway Analysis (IPA) was used to characterize the functions, pathways, and networks of the identified proteins. Alterations of expression levels of proteins detected in samples collected at one week (wk) post-irradiation reflects acute effects of exposure to 48Ti ions, while those detected in samples collected at six months (mos) post-irradiation represent protein expression profiles involved in the induction of late-occurring damage (normally referred to as genomic instability). Our results obtained by using the IPA analyses indicate a wide array of signaling pathways involved in response to 1 GeV\/n 48Ti ions at both harvest times. Our data also demonstrate that the patterns of protein expression profiles are dose and time dependent. The majority of proteins with altered expression levels are involved in cell cycle control, cellular growth and proliferation, cell death and survival, cell-to-cell signaling and interaction. The IPA analyses indicate several important processes involved in responses to exposure to 48Ti ions. These include the proteosme\/ubiquination, protein synthesis, post-translation modification, and lipid metabolism. The IPA analyses also indicate that exposure to 1 GeV\/n 48Ti ions affects the development and function of hematological system, immune cell trafficking, including the cytoskeleton. Further, the IPA analyses strongly demonstrate that the NF-\u03baB and MAPKs (ERKs, JNKs, and p38MAPK) pathways play an essential role in signal transduction after exposure to 1 GeV\/n 48Ti ions. At an early time-point (1 week), the top networks identified by the IPA analyses are related to metabolic disease, lipid metabolism, small molecule biochemistry, and development disorder. In contrast, the top networks identified in samples collected at a late time-point (6 mos post-irradiation) by the IPA analyses are related to cancer, hematological disorders, and immunological diseases. In summary, the proteomic findings from our study provide a foundation to uncover compounds potentially be highly effective in radiation countermeasures.<\/jats:p>","DOI":"10.3390\/proteomes3030132","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T10:17:48Z","timestamp":1437473868000},"page":"132-159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Proteomic Profiling of Hematopoietic Stem\/Progenitor  Cells after a Whole Body Exposure of CBA\/CaJ Mice to Titanium (48Ti) Ions"],"prefix":"10.3390","volume":"3","author":[{"given":"Kanokporn","family":"Rithidech","sequence":"first","affiliation":[{"name":"Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montree","family":"Tungjai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA"},{"name":"Department of Radiologic Technology, Faculty of Associated Medical Sciences, Center of Excellence for Molecular Imaging, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witawat","family":"Jangiam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA"},{"name":"Department of Chemical Engineering, Burapha University, Chonburi 20131, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Honikel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyin","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Room 0044, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Witzmann","sequence":"additional","affiliation":[{"name":"Department of Cellular & Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Room 362A, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2307\/3579651","article-title":"The effects of delta rays on the number of particle-track traversals per cell in laboratory and space exposures","volume":"150","author":"Cucinotta","year":"1998","journal-title":"Radiat. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1470-2045(06)70695-7","article-title":"Cancer risk from exposure to galactic cosmic rays: Implications for space exploration by human beings","volume":"7","author":"Cucinotta","year":"2006","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3579391","article-title":"Studies of the mortality of atomic bomb survivors. Report 12, part I. Cancer: 1950\u20131990","volume":"146","author":"Pierce","year":"1996","journal-title":"Radiat. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mrfmmm.2005.04.025","article-title":"Bystander-mediated genomic instability after high let radiation in murine primary haemopoietic stem cells","volume":"597","author":"Bowler","year":"2006","journal-title":"Mutat. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1080\/09553000110073411","article-title":"Evidence of genetic instability in 3 Gy X-ray-induced mouse leukaemias and 3 Gy X-irradiated haemopoietic stem cells","volume":"77","author":"MacDonald","year":"2001","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-94-007-5896-4_4","article-title":"Serum and plasma proteomics and its possible use as detector and predictor of radiation diseases","volume":"Volume 990","author":"Leszczynski","year":"2013","journal-title":"Radiation Proteomics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/bcmd.1999.0225","article-title":"Advantages of the cba mouse in leukemogenesis research","volume":"25","author":"Rithidech","year":"1999","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1667\/RR1648.1","article-title":"Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 gev\/nucleon 56Fe ions","volume":"172","author":"Weil","year":"2009","journal-title":"Raddiat. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1479-7364-8-13","article-title":"Radiation-induced myeloid leukemia in murine models","volume":"8","author":"Rivina","year":"2014","journal-title":"Hum. Genomics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00411-006-0071-2","article-title":"Relative effectiveness of different particles and energies in disrupting behavioral performance","volume":"46","author":"Rabin","year":"2007","journal-title":"Radiat. Environ. Biophys."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/1874467211104020106","article-title":"In vivo space radiation-induced non-targeted responses: Late effects on molecular signaling in mitochondria","volume":"4","author":"Jain","year":"2011","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/09553002.2015.1001882","article-title":"Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA\/Caj mice","volume":"91","author":"Jangiam","year":"2015","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.3748\/wjg.v9.i12.2726","article-title":"Differentially expressed proteins of gamma-ray irradiated mouse intestinal epithelial cells by two-dimensional electrophoresis and MALDI-TOF mass spectrometry","volume":"9","author":"Zhang","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1080\/09553000902820390","article-title":"Protein-expression profiles in mouse blood-plasma following acute whole-body exposure to 137cs \u03b3 rays","volume":"85","author":"Rithidech","year":"2009","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1002\/pmic.200401295","article-title":"A proteomic analysis of murine bone marrow and its response to ionizing radiation","volume":"5","author":"Chen","year":"2005","journal-title":"Proteomics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/proteomes2030291","article-title":"Bone marrow protein oxidation in response to ionizing radiation in c57bl\/6j mice","volume":"2","author":"Kim","year":"2014","journal-title":"Proteomes"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/095530098140943","article-title":"Radiation-induced genomic instability in haemopoietic cells","volume":"74","author":"Wright","year":"1998","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.1038\/sj.onc.1206883","article-title":"Role of genetic background in induced instability","volume":"22","author":"Kadhim","year":"2003","journal-title":"Oncogene"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.1038\/sj.onc.1204903","article-title":"Inflammatory-type responses after exposure to ionizing radiation in vivo: A mechanism for radiation-induced bystander effects?","volume":"20","author":"Lorimore","year":"2001","journal-title":"Oncogene"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exphem.2007.01.019","article-title":"Radiation leukemogenesis: A proteomic approach","volume":"35","author":"Rithidech","year":"2007","journal-title":"Exp. Hematol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/00004032-199505000-00001","article-title":"Application of the hsef to assessing radiation risks in the practice of radiation protection","volume":"68","author":"Bond","year":"1995","journal-title":"Health Phys."},{"key":"ref_22","unstructured":"Cronkite, E.P., and Bond, V.P. (1988). Radiation Leukemic-prediction of Low Dose Effects, National Cancer Institute."},{"key":"ref_23","first-page":"955","article-title":"Dose-response relationship of radiation-induced harderian gland tumors and myeloid leukemia of the CBA\/Cne mouse","volume":"76","author":"Coppola","year":"1986","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/bjc.1983.37","article-title":"The dose-response for X-ray induction of myeloid leukemia in male CBA\/H mice","volume":"47","author":"Mole","year":"1983","journal-title":"Br. J. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0145-2126(83)90020-6","article-title":"Myeloid leukaemia frequency after protracted exposure to ionizing radiation: Experimental confirmation of the flat dose-response found in ankylosing spondylitis after a single treatment course with X-rays","volume":"7","author":"Mole","year":"1983","journal-title":"Leuk. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1021\/pr2005633","article-title":"A novel alignment method and multipleffilters for exclusion of unqualified peptides to enhance label-free quantification using peptide intensity in LC\u2013MS\/MS","volume":"10","author":"Lai","year":"2011","journal-title":"J. Proteome Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"i131","DOI":"10.1093\/jrr\/rrt193","article-title":"Protein expression profiles in hematopoietic stem\/progenitor cells after exposure of mice to silicon (28Si) ions","volume":"55","author":"Rithidech","year":"2014","journal-title":"J. Rad. Res."},{"key":"ref_28","unstructured":"Ingenuity The ingenuity pathway analysis (IPA) web based software. Available online: Http:\/\/www.Ingenuity.Com."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mrgentox.2013.06.001","article-title":"Effects of 100 Mev protons delivered at 0.5 or 1 CGY\/Min on the in vivo induction of early and delayed chromosomal damage","volume":"756","author":"Rithidech","year":"2013","journal-title":"Mutat. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.asr.2009.05.001","article-title":"Induction of genomic instability after an acute whole-body exposure of mice to 56Fe ions","volume":"44","author":"Rithidech","year":"2009","journal-title":"Adv. Sp. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-59745-536-7_14","article-title":"Hematopoietic colony-forming cell assays","volume":"407","author":"Pereira","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/prca.200780140","article-title":"Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients","volume":"2","author":"Lai","year":"2008","journal-title":"Proteomics Clin. Appl."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"Keller","year":"2002","journal-title":"Anal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal. Chem."},{"key":"ref_35","unstructured":"Discover the Biology. Available online: http:\/\/ingenuity.force.com\/ipa\/articles\/Feature_Description\/Legend."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/nm.3739","article-title":"Ubiquitination in disease pathogenesis and treatment","volume":"20","author":"Popovic","year":"2014","journal-title":"Nat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrm3099","article-title":"The spatial and temporal organization of ubiquitin networks","volume":"12","author":"Grabbe","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbadis.2011.10.013","article-title":"Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils","volume":"1822","author":"Iwasa","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1038\/sj.onc.1206977","article-title":"Increased expression and no mutation of the flap endonuclease (FEN1) gene in human lung cancer","volume":"22","author":"Sato","year":"2003","journal-title":"Oncogene"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-12-386043-9.00005-0","article-title":"New insights into vinculin function and regulation","volume":"287","author":"Peng","year":"2011","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1158\/0008-5472.CAN-04-0591","article-title":"Activation of nuclear factor \u03bab in vivo selectively protects the murine small intestine against ionizing radiation-induced damage","volume":"64","author":"Wang","year":"2004","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1096\/fasebj.13.10.1137","article-title":"Is NF-\u03bab the sensor of oxidative stress?","volume":"13","author":"Li","year":"1999","journal-title":"FASEB J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2045-3701-2-22","article-title":"The protective effect of peroxiredoxin II on oxidative stress induced apoptosis in pancreatic \u03b2-cells","volume":"2","author":"Zhao","year":"2012","journal-title":"Cell Biosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1146\/annurev-biochem-061809-121639","article-title":"Caspase substrates and cellular remodeling","volume":"80","author":"Crawford","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1593\/neo.91930","article-title":"The extracellular matrix glycoprotein elastin microfibril interface located protein 2: A dual role in the tumor microenvironment","volume":"12","author":"Mongiat","year":"2010","journal-title":"Neoplasia"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Colombatti, A., Spessotto, P., Doliana, R., Mongiat, M., Bressan, G.M., and Esposito, G. (2012). The emilin\/multimerin family. Front. Immunol., 2.","DOI":"10.3389\/fimmu.2011.00093"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e0115284","DOI":"10.1371\/journal.pone.0115284","article-title":"Emilin2 regulates platelet activation, thrombus formation, and clot retraction","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"41879","DOI":"10.1074\/jbc.M207990200","article-title":"Binding of two nuclear complexes to a novel regulatory element within the human s100a9 promoter drives the s100a9 gene expression","volume":"277","author":"Kerkhoff","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1110\/ps.035527.108","article-title":"Members of the s100 family bind p53 in two distinct ways","volume":"17","author":"Rutherford","year":"2008","journal-title":"Protein Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1128\/MCB.23.3.1034-1043.2003","article-title":"Loss of s100a9 (MRP14) results in reduced interleukin-8-induced cd11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro","volume":"23","author":"Manitz","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/jid.2014.385","article-title":"Human mitochondrial NAD(P)+-dependent malic enzyme participates in cutaneous melanoma progression and invasion","volume":"135","author":"Chang","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_52","unstructured":"Rithidech, K., Honikel, L., Jangiam, W., Tungjai, M., Gordon, C., and Whorton, E.B. Acute- and late-occurring effects of 48Ti ions on hematopietic stem\/progenitor cells (Hspcs) after a whole body exposure of CBA\/Caj mice, Manuscript in preparation."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1242\/bio.20133244","article-title":"Mitochondrial NDUFS3 regulates the ros-mediated onset of metabolic switch in transformed cells","volume":"2","author":"Suhane","year":"2013","journal-title":"Biol. Open"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1016\/j.jmb.2013.10.022","article-title":"Samhd1 host restriction factor: A link with innate immune sensing of retrovirus infection","volume":"425","author":"Sze","year":"2013","journal-title":"J. Mol. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"14272","DOI":"10.1073\/pnas.1312033110","article-title":"The deoxynucleotide triphosphohydrolase samhd1 is a major regulator of DNA precursor pools in mammalian cells","volume":"110","author":"Franzolin","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1182\/blood-2013-04-490847","article-title":"Samhd1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage","volume":"123","author":"Clifford","year":"2014","journal-title":"Blood"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/sj.jid.5700673","article-title":"Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles","volume":"127","author":"Gu","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_58","first-page":"299","article-title":"Keratins regulate yolk sac hematopoiesis and vasculogenesis through reduced BMP-4 signaling","volume":"89","author":"Vijayaraj","year":"2010","journal-title":"EJCB"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nrm1618","article-title":"Translational control in stress and apoptosis","volume":"6","author":"Holcik","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1158\/0008-5472.CAN-07-5635","article-title":"Targeting the eukaryotic translation initiation factor 4E for cancer therapy","volume":"68","author":"Graff","year":"2008","journal-title":"Cancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8992","DOI":"10.1128\/MCB.23.24.8992-9002.2003","article-title":"Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis","volume":"23","author":"Topisirovic","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1182\/blood-2009-02-205153","article-title":"Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): A proof-of-principle clinical trial with ribavirin","volume":"114","author":"Assouline","year":"2009","journal-title":"Blood"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/carcin\/bgp081","article-title":"Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: A perspective from genetic studies in mice","volume":"30","author":"Rao","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/ncb2994","article-title":"Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells","volume":"16","author":"Ertych","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.freeradbiomed.2014.08.026","article-title":"Manganese superoxide dismutase in breast cancer: From molecular mechanisms of gene regulation to biological and clinical significance","volume":"77","author":"Becuwe","year":"2014","journal-title":"Free Rad. Biol. Med."},{"key":"ref_66","first-page":"2085","article-title":"Overexpression of peroxiredoxin in human breast cancer","volume":"28","author":"Noh","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"10377","DOI":"10.1158\/0008-5472.CAN-05-3036","article-title":"A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability","volume":"66","author":"Kim","year":"2006","journal-title":"Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/bjh.12954","article-title":"Peroxiredoxin 2 expression is increased in neutrophils of patients with refractory cytopenia with multilineage dysplasia","volume":"166","author":"Kazama","year":"2014","journal-title":"Br. J. Haematol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1182\/blood-2011-06-358705","article-title":"Genome-wide analysis of histone H3 acetylation patterns in aml identifies PRDX2 as an epigenetically silenced tumor suppressor gene","volume":"119","author":"Isken","year":"2012","journal-title":"Blood"}],"container-title":["Proteomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-7382\/3\/3\/132\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:49:31Z","timestamp":1760215771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-7382\/3\/3\/132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,21]]},"references-count":69,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,9]]}},"alternative-id":["proteomes3030132"],"URL":"https:\/\/doi.org\/10.3390\/proteomes3030132","relation":{},"ISSN":["2227-7382"],"issn-type":[{"type":"electronic","value":"2227-7382"}],"subject":[],"published":{"date-parts":[[2015,7,21]]}}}