{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:49:46Z","timestamp":1773406186667,"version":"3.50.1"},"reference-count":198,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proteomes"],"abstract":"<jats:p>The early diagnosis of Alzheimer\u2019s disease (AD) has become important to the reversal and treatment of neurodegeneration, which may be relevant to premature brain aging that is associated with chronic disease progression. Clinical proteomics allows the detection of various proteins in fluids such as the urine, plasma, and cerebrospinal fluid for the diagnosis of AD. Interest in lipidomics has accelerated with plasma testing for various lipid biomarkers that may with clinical proteomics provide a more reproducible diagnosis for early brain aging that is connected to other chronic diseases. The combination of proteomics with lipidomics may decrease the biological variability between studies and provide reproducible results that detect a community\u2019s susceptibility to AD. The diagnosis of chronic disease associated with AD that now involves genomics may provide increased sensitivity to avoid inadvertent errors related to plasma versus cerebrospinal fluid testing by proteomics and lipidomics that identify new disease biomarkers in body fluids, cells, and tissues. The diagnosis of AD by various plasma biomarkers with clinical proteomics may now require the involvement of lipidomics and genomics to provide interpretation of proteomic results from various laboratories around the world.<\/jats:p>","DOI":"10.3390\/proteomes4020014","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T10:27:21Z","timestamp":1459420041000},"page":"14","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"4","author":[{"given":"Ian","family":"Martins","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup 6027, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.4236\/health.2014.612190","article-title":"Links between Insulin Resistance, Lipoprotein Metabolism and Amyloidosis in Alzheimer\u2019s Disease","volume":"6","author":"Martins","year":"2014","journal-title":"Health"},{"key":"ref_2","first-page":"1","article-title":"Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities","volume":"9","author":"Martins","year":"2015","journal-title":"J. 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