{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:07:49Z","timestamp":1792728469722,"version":"4.5.0"},"reference-count":76,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proteomes"],"abstract":"<jats:p>With a relatively large surface area (2 m2) and 15% of total body mass, the skin forms the largest organ of the human body. The main functions of the skin include regulation of body temperature by insulation or sweating, regulation of the nervous system, regulation of water content, and protection against external injury. To perform these critical functions, the skin encodes genes for transporters responsible for the cellular trafficking of essential nutrients and metabolites to maintain cellular hemostasis. However, the knowledge on the expression, regulation, and function of these transporters is very limited and needs more work to elucidate how these transporters play a role both in disease progression and in healing. Furthermore, SLC and ABC transporters are understudied, and even less studied in skin. There are sparse reports on relation between transporters in skin and sweat metabolites. This mini review focuses on the current state of SLC and ABC transporters in the skin and their relation to sweat metabolites and skin diseases.<\/jats:p>","DOI":"10.3390\/proteomes9020023","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T02:31:34Z","timestamp":1621218694000},"page":"23","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Current State of SLC and ABC Transporters in the Skin and Their Relation to Sweat Metabolites and Skin Diseases"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-7473","authenticated-orcid":false,"given":"Marcus","family":"Nielsen","sequence":"first","affiliation":[{"name":"Institute of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Aryal","sequence":"additional","affiliation":[{"name":"Institute of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnaz","family":"Safari","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia 5756151818, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-7753","authenticated-orcid":false,"given":"Biljana","family":"Mojsoska","sequence":"additional","affiliation":[{"name":"Institute of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-0335","authenticated-orcid":false,"given":"H\u00e5vard","family":"Jenssen","sequence":"additional","affiliation":[{"name":"Institute of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala","family":"Prabhala","sequence":"additional","affiliation":[{"name":"Institute of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0962-8924(02)02316-4","article-title":"The barrier function of skin: How to keep a tight lid on water loss","volume":"12","author":"Tsuruta","year":"2002","journal-title":"Trends Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1467-2494.2007.00387.x","article-title":"A short history of sweat gland biology","volume":"29","author":"Wilke","year":"2007","journal-title":"Int. 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