{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:41:30Z","timestamp":1760233290567,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007877","name":"Fujita Health University","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/501100007877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Extramedullary plasmacytoma (EMP) is a rare disease consisting of the presence of monoclonal plasma cells in tissues other than the bone. Most EMPs are located in the head and neck region. We present an extremely rare case of an EMP originating from the biliary tract in a 76-year-old male. This is the fifth report of a primary EMP arising from the biliary tract. He was diagnosed with jaundice, and he was referred for an additional examination. Abdominal ultrasonography revealed a tumor in the gallbladder and bile ducts, and a bile duct biopsy was performed via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The pathological and immunohistochemical examination revealed that the tumor was a plasmacytoma originating in the biliary tract. Although endoscopic biliary drainage was performed, the bile duct infection was not well controlled due to obstructive jaundice caused by the tumor. Furthermore, the bleeding from the tumor during chemotherapy was uncontrolled. Pancreaticoduodenectomy and cholecystectomy were performed to control the infection and bleeding. Although chemotherapy was continued after surgery, the tumor of the intrahepatic bile duct enlarged. He died seven months after the diagnosis because of the treatment-resistant tumor.<\/jats:p>","DOI":"10.3390\/reports6010001","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:14:28Z","timestamp":1672370068000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Extramedullary Plasmacytoma of the Biliary Tract with a Poor Prognosis"],"prefix":"10.3390","volume":"6","author":[{"given":"Eiko","family":"Sakurai","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology, Graduate School of Medicine, Fujita Health University, 1\u201398, Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-1763","authenticated-orcid":false,"given":"Kazunori","family":"Nakaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Fujita Health University, 1\u201398, Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Graduate School of Medicine, Fujita Health University, 1\u201398, Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoe","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Hematology, Graduate School of Medicine, Fujita Health University, 1\u201398, Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Graduate School of Medicine, Fujita Health University, 1\u201398, Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9639-7425","authenticated-orcid":false,"given":"Yoshiki","family":"Hirooka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Fujita Health University, 1\u201398, Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-8724","authenticated-orcid":false,"given":"Tetsuya","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Graduate School of Medicine, Fujita Health University, 1\u201398, Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","first-page":"4296802","article-title":"Rare Presentation of Primary Extramedullary Plasmacytoma as Lip Lesion","volume":"2017","author":"Him","year":"2017","journal-title":"Case Rep. Oncol. Med."},{"key":"ref_2","first-page":"47","article-title":"Clinical outcome of extramedullary plasmacytoma","volume":"85","author":"Galieni","year":"2000","journal-title":"Haematologica"},{"key":"ref_3","unstructured":"Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., and Thiele, J. (2017). Plasma cell neoplasms. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, International Agency of Research on Cancer."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0936-6555(05)80547-3","article-title":"Extramedullary plasmacytoma of maxillary sinus with later involvement of the gall bladder and subcutaneous tissues","volume":"7","author":"Kondo","year":"1995","journal-title":"Clin. Oncol. J. (R. Coll. Radiol.)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3109\/10428194.2010.483300","article-title":"Primary hematolymphoid malignancies involving the extrahepatic bile duct or gallbladder","volume":"51","author":"Hwang","year":"2010","journal-title":"Leuk. Lymphoma"},{"key":"ref_6","first-page":"331","article-title":"Extramedullary plasmacytoma imitating neoplasm of the gallbladder fossa after cholecystectomy","volume":"36","author":"Kinda","year":"2012","journal-title":"Coll. Antropol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1055\/s-2007-970386","article-title":"Metastasis of medullary plasmocytoma as the cause of acute cholecystitis","volume":"132","author":"Schuster","year":"2007","journal-title":"Dtsch. Med. Wochenschr."},{"key":"ref_8","first-page":"E7","article-title":"Extramedullary plasmacytoma of the gallbladder diagnosed by endoscopic ultrasound fine needle aspiration (EUS-FNA)","volume":"6","author":"Desai","year":"2015","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.rontge.2008.03.003","article-title":"Extraosseous manifestation of multiple myeloma with unusual appearance in computed tomography--case report","volume":"56","author":"Heckmann","year":"2008","journal-title":"Rontgenpraxis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2169\/internalmedicine.52.9140","article-title":"Multiple myeloma involving the extrahepatic bile duct","volume":"52","author":"Fukatsu","year":"2013","journal-title":"Intern. Med."},{"key":"ref_11","first-page":"e2688","article-title":"A Case of Multiple Myeloma Associated with Extramedullary Plasmacytoma of the Gallbladder Manifesting as Acute Cholecystitis","volume":"10","author":"Abughanimeh","year":"2018","journal-title":"Cureus"},{"key":"ref_12","first-page":"48","article-title":"Multiple myeloma involving the extrahepatic biliary system","volume":"36","author":"Abt","year":"1969","journal-title":"J. Mt. Sinai. Hosp. N. Y."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.21873\/invivo.11769","article-title":"Clinical Features of Head and Neck Solitary Extramedullary Plasmacytoma in Taiwan","volume":"34","author":"Lai","year":"2020","journal-title":"In Vivo"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2141.2008.07421.x","article-title":"Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: Incidence and survival in the United States, 1992\u20132004","volume":"144","author":"Dores","year":"2009","journal-title":"Br. J. Haematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/bjc.1995.26","article-title":"Localised plasmacytomas in Taiwan: Comparison between extramedullary plasmacytoma and solitary plasmacytoma of bone","volume":"71","author":"Shih","year":"1995","journal-title":"Br. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/ccr3.609","article-title":"Solitary extraosseous plasmacytoma","volume":"4","author":"Merza","year":"2016","journal-title":"Clin. Case Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2141.2007.06599.x","article-title":"Solitary plasmacytoma and multiple myeloma: Adhesion molecule and chemokine receptor expression patterns","volume":"137","author":"Hughes","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/s41375-018-0099-8","article-title":"Treatment approaches and outcomes in plasmacytomas: Analysis using a national dataset","volume":"32","author":"Goyal","year":"2018","journal-title":"Leukemia"}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/6\/1\/1\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:55:03Z","timestamp":1760147703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/6\/1\/1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["reports6010001"],"URL":"https:\/\/doi.org\/10.3390\/reports6010001","relation":{},"ISSN":["2571-841X"],"issn-type":[{"type":"electronic","value":"2571-841X"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}