{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:05:12Z","timestamp":1783181112034,"version":"3.54.6"},"reference-count":25,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>This Institutional Review Board (IRB)-approved retrospective observational protocol aims to report the safety and efficacy of birth tissue allografts applied in 38 patients with treatment-resistant sacroiliac (SI) joint pain. The research methodology consisted of an observational recording of the Numeric Pain Rating Scale (NPRS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC), which measure pain, stiffness, and physical function. No adverse events or adverse reactions were observed in the 38 patients. Statistically significant improvements in NPRS and WOMAC scores of the affected SI joint were reported after 90 days. The observational data suggests that Wharton\u2019s jelly allograft applications are safe, minimally invasive, and efficacious. They may present an alternative to surgery for patients who fail conservative and procedural management of pain originating from chondral cartilage degeneration of the SI joint.<\/jats:p>","DOI":"10.3390\/reports6010012","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T04:22:28Z","timestamp":1677730948000},"page":"12","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Durability and Efficacy of Cryopreserved Human Umbilical Cord Tissue Allograft for the Supplementation of Cartilage Defects Associated with the Sacroiliac Joint: A Case Series"],"prefix":"10.3390","volume":"6","author":[{"given":"Albert","family":"Lai","sequence":"first","affiliation":[{"name":"Desert Pain Specialists, 72780 Country Club Drive, #C-300, Rancho Mirage, CA 92270, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Shou","sequence":"additional","affiliation":[{"name":"Regenative Labs, 1700 W Main Street, Pensacola, FL 32502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve A.","family":"Traina","sequence":"additional","affiliation":[{"name":"Western Orthopedics, 1830 Franklin Street, 450, Denver, CO 80218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Barrett","sequence":"additional","affiliation":[{"name":"Regenative Labs, 1700 W Main Street, Pensacola, FL 32502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"ref_1","unstructured":"Raj, M.A., Ampat, G., and Varacallo, M. (2022, September 04). Sacroiliac Joint Pain, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470299."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s004290050200","article-title":"Age-related changes in the articular cartilage of human sacroiliac joint","volume":"198","author":"Kampen","year":"1998","journal-title":"Anat. Embryol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.2106\/JBJS.17.00245","article-title":"Diagnosis and Management of Sacroiliac Joint Dysfunction","volume":"99","author":"York","year":"2017","journal-title":"J. Bone Jt. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5435\/00124635-200407000-00006","article-title":"Sacroiliac Joint Pain","volume":"12","author":"Dreyfuss","year":"2004","journal-title":"J. Am. Acad. Orthop. 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