{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:57:10Z","timestamp":1760147830939,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Ovarian malignant germ cell tumors (OMGCTs) represent a rare type of malignant tumors composed of primitive germ cells that often originate from dysgenetic gonads and are frequently associated with hermaphroditism. Such tumors occur more frequently in adolescents or young adults, and their etiopathogenic mechanism is not well established. We report the case of a 20-year-old female with ovarian dysgenesis and female phenotype. A laparoscopic surgery was performed, and ovotestis was discovered. To achieve a histopathological examination, right oophorectomy was performed, which confirmed the diagnosis of dysgerminoma. In the case of hermaphroditism, mixed germ cell tumors can develop, leading to a more aggressive evolution with bilateral malignancy of the gonads, which requires the removal of both ovotestis. The patient was recalled. A histopathological examination revealed a seminoma, so laparoscopic left oophorectomy was performed. The management of this type of diagnosis primarily involves surgery, minimally invasive interventions being preferred. Not all pathologic conditions are readily identifiable by means of exploratory laparoscopy, as in our patient\u2019s case. We consider that the optimal solution for these patients would be the preservation of fertility via egg donation and embryo transfer; the survival rate of such patients being 97\u2013100%, if the tumor is diagnosed at an early age.<\/jats:p>","DOI":"10.3390\/reports6010014","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T01:35:30Z","timestamp":1678066530000},"page":"14","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Malignant Ovarian Germ Cell Tumor: Dysgerminoma and Seminoma in the Same Patient"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-6353","authenticated-orcid":false,"given":"Melinda-Ildiko","family":"Mitranovici","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7024-2916","authenticated-orcid":false,"given":"Diana Maria","family":"Chiorean","sequence":"additional","affiliation":[{"name":"Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-4755","authenticated-orcid":false,"given":"Sabin Gligore","family":"Turdean","sequence":"additional","affiliation":[{"name":"Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cezara","family":"Mure\u0219an","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-5756","authenticated-orcid":false,"given":"Corneliu-Florin","family":"Buicu","sequence":"additional","affiliation":[{"name":"Public Health and Management Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca","family":"Moraru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liviu","family":"Moraru","sequence":"additional","affiliation":[{"name":"Department of Anatomy, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titiana Cornelia","family":"Cotoi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"},{"name":"Close Circuit Pharmacy of County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-0434","authenticated-orcid":false,"given":"Havva Serap","family":"Toru","sequence":"additional","affiliation":[{"name":"Department of Pathology, Akdeniz University School of Medicine, Antalya P\u0131narba\u015f\u0131, Konyaalt\u0131, Antalya 07070, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6684-1759","authenticated-orcid":false,"given":"Adrian","family":"Apostol","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu","family":"M\u0103rginean","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ion","family":"Petre","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioan Emilian","family":"Oal\u0103","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cPius Brinzeu\u201d County Hospital, 2 Eftimie Murgu Sq, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidiu Simion","family":"Cotoi","sequence":"additional","affiliation":[{"name":"Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania"},{"name":"Department of Pathophysiology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/8756479315599082","article-title":"Ovarian Dysgerminoma: A Case Study","volume":"31","author":"Michael","year":"2015","journal-title":"J. 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