{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:20:49Z","timestamp":1760149249009,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Obstructive sleep apnea (OSA) is well known to often improve with non-supine positioning as opposed to supine positioning. Emerging research supports a role for sleep position management in patients with central sleep apnea (CSA) as well. We report a case of de novo complex sleep apnea syndrome (CompSAS) in a 78-year-old female, who presented after a car accident due to unclear syncope. Diagnostic polysomnography (PSG) showed moderate OSA. A CompSAS developed under automatic positive airway pressure (APAP), while 4 years of downloaded data showed good adherence. No significant benefit was reported under adaptive servo ventilation (ASV) and BiPAP-ST, while a reduction in CSA in the non-supine position was noticed. Oxygen and sleep positional therapy (SPT) were considered, resulting in a significant improvement in CSA and sleep quality. Further research on the prevalence of positional CSA is needed.<\/jats:p>","DOI":"10.3390\/reports6030032","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:35:16Z","timestamp":1689644116000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of De Novo Positional Complex Sleep Apnea Syndrome (CompSAS)"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9503-4200","authenticated-orcid":false,"given":"Abdelkarim","family":"Khalifa","sequence":"first","affiliation":[{"name":"Sleep Medicine Center Zurich Oberland, GZO Wetzikon, 8620 Wetzikon, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-6977","authenticated-orcid":false,"given":"Marc","family":"Spielmanns","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center Zurich Oberland, GZO Wetzikon, 8620 Wetzikon, Switzerland"},{"name":"Faculty of Health, Department for Pulmonary Medicine, University Witten Herdecke, 58455 Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1161\/01.CIR.0000061758.05044.64","article-title":"Sleep apnea and heart failure: Part II: Central sleep apnea","volume":"107","author":"Bradley","year":"2003","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1213\/ANE.0000000000001546","article-title":"Understanding phenotypes of obstructive sleep apnea: Applications in anesthesia, surgery, and perioperative medicine","volume":"124","author":"Subramani","year":"2017","journal-title":"Anesth. Analg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.sleep.2009.05.014","article-title":"Impact of sleeping position on central sleep apnea\/Cheyne\u2013Stokes respiration in patients with heart failure","volume":"11","author":"Joho","year":"2010","journal-title":"Sleep Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5664\/jcsm.2496","article-title":"A Case of Positional Central Sleep Apnea","volume":"9","author":"Zaharna","year":"2013","journal-title":"J. Clin. Sleep Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1164\/ajrccm.150.6.7952621","article-title":"Effect of continuous positive airway pressure on central sleep apnea and nocturnal PCO2 in heart failure","volume":"150","author":"Naughton","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1378\/chest.90.2.165","article-title":"Reversal of Central Sleep Apnea Using Nasal CPAP","volume":"90","author":"Issa","year":"1986","journal-title":"Chest"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1378\/chest.07-1715","article-title":"Efficacy of Adaptive Servoventilation in Treatment of Complex and Central Sleep Apnea Syndromes","volume":"132","author":"Allam","year":"2007","journal-title":"Chest"},{"key":"ref_8","first-page":"PA2388","article-title":"Positional therapy as a treatment for central sleep apnoea: A prospective multicentre trial","volume":"48","author":"Benosit","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/resp.12927","article-title":"Pathogenesis of central and complex sleep apnoea","volume":"22","author":"Orr","year":"2016","journal-title":"Respirology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1183\/09031936.00162009","article-title":"A prospective polysomnographic study on the evolution of complex sleep apnoea","volume":"38","author":"Cassel","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1109\/TBME.2010.2047505","article-title":"An Invasive and a Noninvasive Approach for the Automatic Differentiation of Obstructive and Central Hypopneas","volume":"57","author":"Morgenstern","year":"2010","journal-title":"IEEE Trans. Biomed. Eng."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/6\/3\/32\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:13:45Z","timestamp":1760127225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/6\/3\/32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["reports6030032"],"URL":"https:\/\/doi.org\/10.3390\/reports6030032","relation":{},"ISSN":["2571-841X"],"issn-type":[{"type":"electronic","value":"2571-841X"}],"subject":[],"published":{"date-parts":[[2023,7,18]]}}}