{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:34:12Z","timestamp":1772645652115,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Accidental soft tissue injuries are a frequent injury. Platelet-rich plasma (PRP) is an interesting therapeutic option for wounds and skin damage. In this case report, we describe a 37-year-old man that presented to our ward of pain medicine for an accidental severe leg injury associated with skin and soft tissue loss, with severe pain and poor sensation. History revealed the use of recreational drugs without viral infections or systemic diseases. Wound debridement, wound dressings, systemic antibiotics (amoxicillin 1000 mg tid and azithromycin 500 mg od), and non-steroidal anti-inflammatory drugs (ibuprofen 600 mg bid) reduced pain but did not improve the skin and soft tissue. A fibrin membrane with concentrated growth factors was applied, yielding an improvement in the injury in 16 months without the need for skin grafting.<\/jats:p>","DOI":"10.3390\/reports6030034","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T01:12:28Z","timestamp":1690161148000},"page":"34","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heterologous Platelet-Rich Plasma in the Treatment of Severe Skin Damage"],"prefix":"10.3390","volume":"6","author":[{"given":"Cristina","family":"Vocca","sequence":"first","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"},{"name":"Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Primary Care, ASP 7, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-9551","authenticated-orcid":false,"given":"Gianmarco","family":"Marcian\u00f2","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"},{"name":"Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Cianconi","sequence":"additional","affiliation":[{"name":"Dentirsty Unit, 00118 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davida","family":"Mirra","sequence":"additional","affiliation":[{"name":"Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Dominijanni","sequence":"additional","affiliation":[{"name":"Immunohaematology and Transfusion Medicine Unit, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-6579","authenticated-orcid":false,"given":"Giovambattista","family":"De Sarro","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"},{"name":"Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"},{"name":"Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-7902","authenticated-orcid":false,"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[{"name":"Operative Unit of Pharmacology and Pharmacovigilance, \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"},{"name":"Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"},{"name":"Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"},{"name":"Medifarmagen Srl, University of Catanzaro and \u201cRenato Dulbecco\u201d University Hospital, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00042728-200506000-00011","article-title":"Normal cutaneous wound healing: Clinical correlation with cellular and molecular events","volume":"31","author":"Baum","year":"2005","journal-title":"Dermatol. 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