{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:39:14Z","timestamp":1760150354504,"version":"build-2065373602"},"reference-count":101,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development (AMED)","doi-asserted-by":"publisher","award":["JP23fk0210132"],"award-info":[{"award-number":["JP23fk0210132"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Hepatitis E virus (HEV) genotypes 3 and 4 are zoonotic strains that are primarily transmitted through the consumption of undercooked pork or game meat. They also cause asymptomatic infections, acute hepatitis, acute-on-chronic liver failure, chronic hepatitis, and extrahepatic manifestations. Here, we report a man in his 80s who had chronic hepatitis B, took entecavir for it, and presented with higher levels of alanine aminotransferase (ALT) and jaundice. An abdominal computed tomography scan revealed choledocholithiasis with cholecystolithiasis. Although endoscopic papillary balloon dilatation was performed for the removal of a common bile duct stone, the abnormal liver function tests, including jaundice, were prolonged. After other viral hepatitis and other causes of the liver injury were ruled out, as his serum was positive for immunoglobulin A anti-HEV and HEV genotype 3b RNA, we diagnosed him as having acute hepatitis E. In this case, with chronic hepatitis B and a common bile duct stone, the prolonged abnormal results for the liver function tests seemed to be caused by HEV infection. In conclusion, in cases with high ALT levels after removing choledocholithiasis, other factors, including HEV infection, should be considered to determine the cause of abnormal liver function test results. The further examination of hepatitis D virus infection and high ALT levels may be needed in HBV-infected individuals.<\/jats:p>","DOI":"10.3390\/reports6040055","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:23:43Z","timestamp":1700213023000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatitis E Virus Infection Caused Elevation of Alanine Aminotransferase Levels in a Patient with Chronic Hepatitis B and Choledocholithiasis"],"prefix":"10.3390","volume":"6","author":[{"given":"Rei","family":"Hirano","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1654-5385","authenticated-orcid":false,"given":"Tatsuo","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Honda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Arima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Totsuka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-4397","authenticated-orcid":false,"given":"Ryota","family":"Masuzaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shini","family":"Kanezawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotaka","family":"Ishii","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Nomura","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-9318","authenticated-orcid":false,"given":"Masaharu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0827-0964","authenticated-orcid":false,"given":"Hiroaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-7309","authenticated-orcid":false,"given":"Hirofumi","family":"Kogure","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, 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therapy","volume":"13","author":"Dunn","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.3748\/wjg.v13.i30.4152","article-title":"Plasmapheresis and corticosteroid treatment for persistent jaundice after successful drainage of common bile duct stones by endoscopic retrograde cholangiography","volume":"13","author":"Saritas","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3109\/00365521.2015.1121516","article-title":"A prospective study on the causes of notably raised alanine aminotransferase (ALT)","volume":"51","author":"Olafsson","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_6","first-page":"153","article-title":"Elevation of ALT to AST ratio in patients with enteroviral myocarditis","volume":"26","author":"Kanda","year":"1995","journal-title":"J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (2018). EASL Clinical Practice Guidelines on hepatitis E virus infection. J. Hepatol., 68, 1256\u20131271.","DOI":"10.1016\/j.jhep.2018.03.005"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Yoshida, Y., Ito, A., Eto, H., Suzuki, A., Abe, T., Endo, K., Kakisaka, K., Oikawa, T., Kuroda, H., and Miyasaka, A. (2023). Seroprevalence and incidence of hepatitis E virus infection in the general population of Iwate prefecture, Japan: A retrospective cohort study. Hepatol Res., online ahead of print.","DOI":"10.1111\/hepr.13961"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1128\/JCM.40.9.3209-3218.2002","article-title":"Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan","volume":"40","author":"Mizuo","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1128\/JCM.43.1.49-56.2005","article-title":"Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) Is highly specific for diagnosis of acute HEV infection","volume":"43","author":"Takahashi","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00705-008-0179-6","article-title":"Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces","volume":"153","author":"Takahashi","year":"2008","journal-title":"Arch. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000441387","article-title":"Recent Trend of Hepatitis E Virus Infection in Chiba Area, Japan: 3 of 5 Cases with Rheumatoid Arthritis","volume":"9","author":"Kanda","year":"2015","journal-title":"Case Rep. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12328-022-01733-2","article-title":"Chronic hepatitis E in an elderly immunocompetent patient who achieved a sustained virologic response with ribavirin treatment","volume":"16","author":"Takakusagi","year":"2023","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1023\/A:1015054510949","article-title":"Fulminant hepatic failure associated with triazolam","volume":"47","author":"Kanda","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/gut.2003.038331","article-title":"Extrahepatic biliary obstruction after percutaneous tumour ablation for hepatocellular carcinoma: Aetiology and successful treatment with endoscopic papillary balloon dilatation","volume":"54","author":"Sasahira","year":"2005","journal-title":"Gut"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/1097-0142(197703)39:3<1306::AID-CNCR2820390343>3.0.CO;2-K","article-title":"A minute hepatocellular carcinoma found in a liver with clonorchis sinensis infection: Report of two cases","volume":"39","author":"Nakashima","year":"1977","journal-title":"Cancer"},{"key":"ref_17","unstructured":"World Health Organization (2023, November 08). Hepatitis E. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-e."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/00365521.2017.1420218","article-title":"Low prevalence of hepatitis E in Iceland: A seroepidemiological study","volume":"53","author":"Olafsson","year":"2018","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00004836-200111000-00017","article-title":"Acute hepatitis E virus infection presenting as a prolonged cholestatic jaundice","volume":"33","author":"Mechnik","year":"2001","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.3748\/wjg.v22.i24.5568","article-title":"Hepatitis E in Israel: A nation-wide retrospective study","volume":"22","author":"Lachish","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1800067","DOI":"10.2807\/1560-7917.ES.2018.23.49.1800067","article-title":"Hepatitis E in pigs in Israel: Seroprevalence, molecular characterisation and potential impact on humans","volume":"23","author":"Shirazi","year":"2018","journal-title":"Eurosurveillance"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"bcr2017223616","DOI":"10.1136\/bcr-2017-223616","article-title":"Acute hepatitis E superinfection leading to chronic hepatitis B reactivation","volume":"2018","author":"Aslam","year":"2018","journal-title":"BMJ Case Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/00365521.2019.1657177","article-title":"A significant proportion of patients with choledocholithiasis have markedly elevated alanine aminotransferase","volume":"54","year":"2019","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MEG.0000000000000781","article-title":"Investigation of liver dysfunction: Who should we test for hepatitis E?","volume":"29","author":"Wallace","year":"2017","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ishida, S., Yoshizumi, S., Sakata, H., and Matsubayashi, K. (2022). Broadly Reactive Real-Time RT-PCR Assay for the Detection of Hepatitis E Virus and Simultaneous Genotyping by Single Nucleotide Polymorphism Analysis. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.01912-21"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3934\/microbiol.2022036","article-title":"Detection of hepatitis E virus RNA from pig bile collected at a slaughterhouse in Japan","volume":"8","author":"Uema","year":"2022","journal-title":"AIMS Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Takahashi, M., Kunita, S., Nishizawa, T., Ohnishi, H., Primadharsini, P.P., Nagashima, S., Murata, K., and Okamoto, H. (2023). Infection Dynamics and Genomic Mutations of Hepatitis E Virus in Naturally Infected Pigs on a Farrow-to-Finish Farm in Japan: A Survey from 2012 to 2021. Viruses, 15.","DOI":"10.3390\/v15071516"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Denner, J., Pischke, S., Steinmann, E., Bl\u00fcmel, J., and Glebe, D. (2019). Why all blood donations should be tested for hepatitis E virus (HEV). BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4190-1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1111\/liv.14221","article-title":"Incidence, predictors and prognosis of genotype 4 hepatitis E related liver failure: A tertiary nested case-control study","volume":"39","author":"Wang","year":"2019","journal-title":"Liver Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12985-021-01714-w","article-title":"Hepatitis E virus infection in a patient with alcohol related chronic liver disease: A case report of acute-on-chronic liver failure","volume":"18","author":"Fantilli","year":"2021","journal-title":"Virol. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3851\/IMP2317","article-title":"Ribavirin therapy for hepatitis E virus-induced acute on chronic liver failure: A preliminary report","volume":"17","author":"Goyal","year":"2012","journal-title":"Antivir. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1053\/j.gastro.2010.08.002","article-title":"Ribavirin therapy inhibits viral replication on patients with chronic hepatitis E virus infection","volume":"139","author":"Kamar","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e0190621","DOI":"10.1128\/jvi.01906-21","article-title":"Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug Screening","volume":"96","author":"Primadharsini","year":"2022","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e0050823","DOI":"10.1128\/jvi.00508-23","article-title":"Development of a HiBiT-tagged reporter hepatitis E virus and its utility as an antiviral drug screening platform","volume":"97","author":"Nagashima","year":"2023","journal-title":"J. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejogrb.2020.11.052","article-title":"Viral Hepatitis in pregnancy","volume":"256","author":"Chilaka","year":"2021","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40203-021-00093-y","article-title":"In silico and in vitro screening of licensed antimalarial drugs for repurposing as inhibitors of hepatitis E virus","volume":"9","author":"Metzger","year":"2021","journal-title":"In Silico Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s15010-018-1168-7","article-title":"Autochthonous acute hepatitis E: Treatment with sofosbuvir and ribavirin","volume":"46","author":"Biliotti","year":"2018","journal-title":"Infection"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"104997","DOI":"10.1016\/j.antiviral.2020.104997","article-title":"Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90","volume":"185","author":"Nimgaonkar","year":"2021","journal-title":"Antiviral. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jhep.2022.12.010","article-title":"Targeting proteostasis of the HEV replicase to combat infection in preclinical models","volume":"78","author":"Zhang","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hooda, P., Chaudhary, M., Parvez, M.K., Sinha, N., and Sehgal, D. (2022). Inhibition of Hepatitis E Virus Replication by Novel Inhibitor Targeting Methyltransferase. Viruses, 14.","DOI":"10.3390\/v14081778"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"104967","DOI":"10.1016\/j.antiviral.2020.104967","article-title":"Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation","volume":"184","author":"Li","year":"2020","journal-title":"Antivir. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"eabj5908","DOI":"10.1126\/sciadv.abj5908","article-title":"Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids","volume":"8","author":"Li","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-981-99-1304-6_9","article-title":"Liver Organoid Potential Application for Hepatitis E Virus Infection","volume":"1417","author":"Xiang","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e22104","DOI":"10.1096\/fj.202101042R","article-title":"Hepatitis E virus-encoded microRNA promotes viral replication by inhibiting type I interferon","volume":"36","author":"Qian","year":"2022","journal-title":"FASEB J."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Costafreda, M.I., Sauleda, S., Riveiro-Barciela, M., Rico, A., Llorens-Revull, M., Guix, S., Pint\u00f3, R.M., Bosch, A., Rodr\u00edguez-Fr\u00edas, F., and Rando, A. (2023). Specific Plasma MicroRNA Signatures Underlying the Clinical Outcomes of Hepatitis E Virus Infection. Microbiol. Spectr., 11.","DOI":"10.1128\/spectrum.04664-22"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.gene.2018.06.108","article-title":"Conservation and variation of the hepatitis E virus ORF2 capsid protein","volume":"675","author":"Zhang","year":"2018","journal-title":"Gene"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.csbj.2021.03.038","article-title":"Structural and molecular biology of hepatitis E virus","volume":"19","author":"Wang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Li, Y., Huang, X., Zhang, Z., Li, S., Zhang, J., Xia, N., and Zhao, Q. (2020). Prophylactic Hepatitis E Vaccines: Antigenic Analysis and Serological Evaluation. Viruses, 12.","DOI":"10.3390\/v12010109"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10198","DOI":"10.1073\/pnas.91.21.10198","article-title":"Successful passive and active immunization of cynomolgus monkeys against hepatitis E","volume":"91","author":"Tsarev","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/S0264-410X(97)00145-X","article-title":"Recombinant vaccine against hepatitis E: Dose response and protection against heterologous challenge","volume":"15","author":"Tsarev","year":"1997","journal-title":"Vaccine"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1056\/NEJMoa061847","article-title":"Safety and efficacy of a recombinant hepatitis E vaccine","volume":"356","author":"Shrestha","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/j.vaccine.2004.11.064","article-title":"A bacterially expressed particulate hepatitis E vaccine: Antigenicity, immunogenicity and protectivity on primates","volume":"23","author":"Li","year":"2005","journal-title":"Vaccine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(10)61030-6","article-title":"Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: A large-scale, randomised, double-blind placebo-controlled, phase 3 trial","volume":"376","author":"Zhu","year":"2010","journal-title":"Lancet"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.vaccine.2022.12.064","article-title":"Immunogenicity and safety of a two-dose regimen with hepatitis E virus vaccine in healthy adults in rural Bangladesh: A randomized, double-blind, controlled, phase 2\/pilot trial","volume":"41","author":"Aziz","year":"2023","journal-title":"Vaccine"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1016\/j.vaccine.2017.05.072","article-title":"A phase 1 randomized open-label clinical study to evaluate the safety and tolerability of a novel recombinant hepatitis E vaccine","volume":"35","author":"Cao","year":"2017","journal-title":"Vaccine"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.3748\/wjg.v24.i43.4870","article-title":"Acute acalculous cholecystitis in children","volume":"24","author":"Poddighe","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.12998\/wjcc.v11.i6.1410","article-title":"Hepatitis A virus-associated acute acalculous cholecystitis in an adult-onset Still\u2019s disease patient: A case report and review of the literature","volume":"11","author":"Chang","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"398","DOI":"10.7326\/0003-4819-120-5-199403010-00008","article-title":"Hepatitis A virus-associated cholecystitis","volume":"120","author":"Mourani","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/00005176-200101000-00024","article-title":"The association of hepatitis A virus infection, acalculous cholecystitis, and blunt abdominal trauma: A diagnostic challenge","volume":"32","author":"Ciftci","year":"2001","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00004836-200307000-00020","article-title":"Acute viral cholecystitis due to hepatitis A virus infection","volume":"37","author":"Ozaras","year":"2003","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1007\/s10620-005-2874-4","article-title":"An unusual cause of acalculous cholecystitis during pregnancy: Hepatitis A virus","volume":"50","author":"Kisacik","year":"2005","journal-title":"Dig. Dis. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.medmal.2007.10.003","article-title":"Hepatitis A: A rare cause of acalculous cholecystitis in children","volume":"38","author":"Bouyahia","year":"2008","journal-title":"Med. Mal. Infect."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4103\/1319-3767.56098","article-title":"Acute acalculous cholecystitis revealing hepatitis A virus infection in children","volume":"15","author":"Arroud","year":"2009","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1590\/S1413-86702009000100017","article-title":"Acute acalculous cholecystitis in a teenager with hepatitis a virus infection: A case report","volume":"13","author":"Souza","year":"2009","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/1596-3519.82059","article-title":"Acute acalculous cholecystitis due to hepatitis A infection in a child: A rare cause of acute abdomen","volume":"10","author":"Herek","year":"2011","journal-title":"Ann. Afr. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/PEC.0b013e318258bdda","article-title":"Unusual cause of abdominal pain in pediatric emergency medicine","volume":"28","author":"Prashanth","year":"2012","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_67","first-page":"407182","article-title":"Acute Acalculous Cholecystitis due to Viral Hepatitis A","volume":"2013","author":"Kaya","year":"2013","journal-title":"Case Rep. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Aldaghi, M., Haghighat, M., and Dehghani, S.M. (2014). Gallbladder hydrops due to viral hepatitis A infection: A case report. Jundishapur. J. Microbiol., 8.","DOI":"10.5812\/jjm.15779"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e7254","DOI":"10.1002\/ccr3.7254","article-title":"HAV-induced acalculous cholecystitis: A case report and literature review","volume":"25","author":"Salajegheh","year":"2023","journal-title":"Clin. Case Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2169\/internalmedicine.45.1460","article-title":"Hepatitis B-related polyarteritis nodosa presenting necrotizing vasculitis in the hepatobiliary system successfully treated with lamivudine, plasmapheresis and glucocorticoid","volume":"45","author":"Takeshita","year":"2006","journal-title":"Intern. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijscr.2015.12.020","article-title":"Acute acalculous cholecystitis caused by Hepatitis C: A rare case report","volume":"19","author":"Omar","year":"2016","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s41182-016-0016-7","article-title":"Genotype 1 hepatitis E virus infection with acute acalculous cholecystitis as an extrahepatic symptom: A case report","volume":"44","author":"Fujioka","year":"2016","journal-title":"Trop. Med. Health"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"77","DOI":"10.47892\/rgp.2020.401.1035","article-title":"Hepatitis A and hepatitis E virus co-infection with right pleural effusion, ascites and acute acalculous cholecystitis. A case report","volume":"40","year":"2020","journal-title":"Rev. Gastroenterol. Peru"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3748\/wjg.v21.i2.502","article-title":"Hepatitis B virus infection, diabetes mellitus, and their synergism for cholangiocarcinoma development: A case-control study in Korea","volume":"21","author":"Lee","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Cho, I.R., Yi, S.W., Choi, J.S., and Yi, J.J. (2022). Comparison of Risk Factors for Cholangiocarcinoma and Hepatocellular Carcinoma: A Prospective Cohort Study in Korean Adults. Cancers, 14.","DOI":"10.3390\/cancers14071709"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1097\/MEG.0000000000000754","article-title":"Hepatitis B virus infection and risk of gallstones: A systematic review and meta-analysis","volume":"28","author":"Wijarnpreecha","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/hep.20647","article-title":"Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States","volume":"41","author":"Bini","year":"2005","journal-title":"Hepatology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2893.2007.00845.x","article-title":"HCV infection is a risk factor for gallstone disease in liver cirrhosis: An Italian epidemiological survey","volume":"14","author":"Stroffolini","year":"2007","journal-title":"J. Viral Hepat."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1365-2893.2009.01141.x","article-title":"Hepatitis C virus infection is a risk factor for gallstone disease: A prospective hospital-based study of patients with chronic viral C hepatitis","volume":"16","author":"Acalovschi","year":"2009","journal-title":"J. Viral Hepat."},{"key":"ref_80","first-page":"84","article-title":"Hepatitis C\u2014A risk factor for gallstone disease","volume":"26","author":"Shah","year":"2014","journal-title":"J. Ayub. Med. Coll. Abbottabad."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000444252","article-title":"Hepatitis C Virus Infection Is Positively Associated with Gallstones in Liver Cirrhosis","volume":"93","author":"Zhang","year":"2016","journal-title":"Digestion"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/jebm.12277","article-title":"Hepatitis C virus infection and risk of gallstones: A meta-analysis","volume":"10","author":"Wijarnpreecha","year":"2017","journal-title":"J. Evid. Based Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1038\/s41598-018-22896-4","article-title":"Hepatitis C Virus Infection Increases Risk of Gallstone Disease in Elderly Chinese Patients with Chronic Liver Disease","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1080\/00365521.2019.1666163","article-title":"Hepatitis E virus genotype 3 is associated with gallstone-related disease","volume":"54","author":"Karlsson","year":"2019","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1002\/ijc.22375","article-title":"Biliary tract cancer and stones in relation to chronic liver conditions: A population-based study in Shanghai, China","volume":"120","author":"Hsing","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref_86","first-page":"1593","article-title":"Increasing prevalence of gallstones in male veterans with alcoholic cirrhosis","volume":"85","author":"Iber","year":"1990","journal-title":"Am. J. Gastroenterol."},{"key":"ref_87","first-page":"1179","article-title":"Incidence of gallstones in liver cirrhosis","volume":"86","author":"Acalovschi","year":"1991","journal-title":"Am. J. Gastroenterol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jceh.2021.09.011","article-title":"Gallstone Disease in Cirrhosis-Pathogenesis and Management","volume":"12","author":"Mallick","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0016-5107(06)80114-8","article-title":"Endoscopic sphincterotomy in patients with liver cirrhosis","volume":"43","author":"Prat","year":"1996","journal-title":"Gastrointest. Endosc."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4253\/wjge.v10.i11.354","article-title":"Endoscopic retrograde cholangiopancreatography in cirrhosis\u2014A systematic review and meta-analysis focused on adverse events","volume":"10","author":"Mashiana","year":"2018","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_91","first-page":"220","article-title":"Infection with delta agent in Japan","volume":"32","author":"Omata","year":"1985","journal-title":"Hepatogastroenterology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2893.2000.00244.x","article-title":"Molecular analysis of hepatitis D virus infection in Miyako Island, a small Japanese island","volume":"7","author":"Arakawa","year":"2000","journal-title":"J. Viral Hepat."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jhep.2023.02.041","article-title":"Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV\/HDV-prevalence countries","volume":"79","author":"Razavi","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/hepr.13936","article-title":"Recent prevalence and characteristics of patients with hepatitis delta virus in Hokkaido, Japan","volume":"53","author":"Sasaki","year":"2023","journal-title":"Hepatol. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/jmv.25570","article-title":"HDV infection in immigrant populations","volume":"91","author":"Coppola","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Tseligka, E.D., Cl\u00e9ment, S., and Negro, F. (2021). HDV Pathogenesis: Unravelling Ariadne\u2019s Thread. Viruses, 13.","DOI":"10.3390\/v13050778"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jhep.2020.11.032","article-title":"New insights into HDV persistence: The role of interferon response and implications for upcoming novel therapies","volume":"74","author":"Zhang","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Elazar, M., and Glenn, J.S. (2022). Combination of Novel Therapies for HDV. Viruses, 14.","DOI":"10.3390\/v14020268"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"100893","DOI":"10.1016\/j.jhepr.2023.100893","article-title":"Broad-spectrum activity of bulevirtide against clinical isolates of HDV and recombinant pan-genotypic combinations of HBV\/HDV","volume":"5","author":"Mateo","year":"2023","journal-title":"JHEP Rep."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Negro, F., and Lok, A.S. (2023). Hepatitis D: A Review. JAMA, online ahead of print.","DOI":"10.1001\/jama.2023.23242"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Heuschkel, M.J., Bach, C., Meiss-Heydmann, L., Gerges, E., Felli, E., Giannone, F., Pessaux, P., Schuster, C., Lucifora, J., and Baumert, T.F. (2023). JAK1 promotes HDV replication and is a potential target for antiviral therapy. J. Hepatol., in press.","DOI":"10.1016\/j.jhep.2023.10.030"}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/6\/4\/55\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:24:57Z","timestamp":1760131497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/6\/4\/55"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,17]]},"references-count":101,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["reports6040055"],"URL":"https:\/\/doi.org\/10.3390\/reports6040055","relation":{},"ISSN":["2571-841X"],"issn-type":[{"type":"electronic","value":"2571-841X"}],"subject":[],"published":{"date-parts":[[2023,11,17]]}}}