{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:09:45Z","timestamp":1764601785144,"version":"build-2065373602"},"reference-count":15,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>A 31-year-old man was diagnosed with a COVID-19 infection, presenting with a diffuse headache and an uneven sensation of fullness, despite having no prior systemic diseases. 99mTc-ECD Brain SPECT\/CT revealed a marked decrease in blood perfusion in the cerebral cortices, predominantly in the frontal region and involving the olfactory sulcus. In contrast, there was increased perfusion in the occipital lobe and asymmetrical perfusion in the cerebellum. This case highlights changes in regional blood flow perfusion that might affect the functional connectivity of the pain matrix, leading to the onset of headaches and associated underlying mechanisms.<\/jats:p>","DOI":"10.3390\/reports6040058","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T05:28:21Z","timestamp":1701667701000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abnormalities in Regional Cerebral Blood Flow Due to Headache in a COVID-19 Infected Patient Observed on 99mTC-ECD Brain SPECT\/CT"],"prefix":"10.3390","volume":"6","author":[{"given":"Ya-Chun","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City 81314, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4005-2094","authenticated-orcid":false,"given":"Shin-Tsu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung City 813414, Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital and National Defense Medical Center, Taipei City 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Yen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City 81314, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Hueng-Yuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City 81314, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9741-5824","authenticated-orcid":false,"given":"Hung-Pin","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City 81314, Taiwan"},{"name":"Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung City 804, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s00415-021-10406-y","article-title":"Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19)","volume":"268","author":"Harapan","year":"2021","journal-title":"J. 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