{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:57Z","timestamp":1760143317994,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Caused by age or trauma, collapsed connective tissue can cause nerve entrapment and damage within the tarsal tunnel. Tarsal tunnel syndrome is relatively underdiagnosed. This study presents an intervention targeting damaged tissues surrounding the nerves and replacing the structural cushioning with a Wharton\u2019s jelly tissue allograft. The eight patients in our study, selected from four clinical sites, had tarsal tunnel-related defects. Patient outcomes were tracked on a 90-day calendar utilizing the Numeric Pain Rating Scale (NPRS) and the Western Ontario and McMaster University Arthritis Index (WOMAC). All patients had failed standard care practices for at least six weeks. Each patient received a Wharton\u2019s jelly tissue allograft to sites around the affected tarsal tunnel. No patients experienced adverse reactions. The percent change results calculated from the initial application to the 90-day follow-up showed an improvement of 59.43% in NPRS and a 37.58% improvement in WOMAC. This study provides evidence that WJ allograft applications are safe, minimally invasive, and efficacious for patients who have failed standard care treatments for tissue defects associated with tarsal tunnel syndrome. The limitations of this study include its small cohort size and nonblinded nature. The results of this study warrant further research to confirm the efficacy, optimal dose, protocol, and durability of Wharton\u2019s jelly.<\/jats:p>","DOI":"10.3390\/reports7010008","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:35:34Z","timestamp":1706614534000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wharton\u2019s Jelly Tissue Allograft for Connective Tissue Defects Surrounding Nerves in the Tarsal Tunnel: A Retrospective Case Series"],"prefix":"10.3390","volume":"7","author":[{"given":"Ronald","family":"Bruton","sequence":"first","affiliation":[{"name":"Advanced Medicine of the Ozarks, Mountain Home, AR 72653, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracie L.","family":"Gilliland","sequence":"additional","affiliation":[{"name":"Advanced Medicine of the Ozarks, Mountain Home, AR 72653, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Shou","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crislyn G.","family":"Woods","sequence":"additional","affiliation":[{"name":"Regenative Labs, Pensacola, FL 32501, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi E.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Regenative Labs, Pensacola, FL 32501, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler C.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Regenative Labs, Pensacola, FL 32501, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.5606\/tftrd.2021.6797","article-title":"Assessment of the frequency of tarsal tunnel syndrome in rheumatoid arthritis","volume":"67","year":"2021","journal-title":"Turk. 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