{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:45:27Z","timestamp":1760143527297,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>(1) Background: Synchronous tumors are defined as tumors that occur at the same time, appearing within 2 months, according to the Surveillance Epidemiology and End Results Program, with a frequency of tertiary tumors of 0.5%. The purpose of this presentation is to report a case of three synchronous tumors of the female genital tract, given the fact that it represents a challenge both therapeutically and in demonstrating that the malignant lesions are completely different from each other. (2) Methods: We report the case of a 45 year-old patient diagnosed with three synchronous tumors developed in the genital tract: clear-cell ovarian carcinoma, uterine endometrioid adenocarcinoma, and cervical adenosquamous carcinoma. (3) Results: Total hysterectomy with bilateral anexectomy was performed and accompanied by a biopsy of the greater omentum. The evolution of the patient was favorable during chemotherapy, but she died two weeks after the completion of this treatment, from a cause secondary to the adverse effects determined by it, namely, severe thrombopenia which caused a massive lower digestive hemorrhage. (4) Conclusions: This case demonstrates the maximum importance of the involvement of adjuvant diagnostic techniques, especially when it comes to a diagnostic challenge with direct implications in the subsequent therapy of the patient.<\/jats:p>","DOI":"10.3390\/reports7010014","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T03:18:38Z","timestamp":1708312718000},"page":"14","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract"],"prefix":"10.3390","volume":"7","author":[{"given":"M\u0103d\u0103lina","family":"Bo\u0219oteanu","sequence":"first","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Department of Pathology, Faculty of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900527 Constan\u021ba, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9396-2350","authenticated-orcid":false,"given":"Raluca Ioana","family":"Vod\u0103","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, \u201cOvidius\u201d University of Constan\u0163a, 900591 Constan\u021ba, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-9797","authenticated-orcid":false,"given":"Gabriela Izabela","family":"Bal\u0163\u01cetescu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, \u201cOvidius\u201d University of Constan\u0163a, 900591 Constan\u021ba, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"A\u015fchie","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, \u201cOvidius\u201d University of Constan\u0163a, 900591 Constan\u021ba, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana-Andreea","family":"Nurla","sequence":"additional","affiliation":[{"name":"\u201cElias\u201d Emergency University Hospital, Dermatovenerology Department, 011461 Bucharest, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900573 Constan\u0163a, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-3200","authenticated-orcid":false,"given":"Cristian Ionu\u0163","family":"Or\u01ce\u015fanu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, \u201cOvidius\u201d University of Constan\u0163a, 900591 Constan\u021ba, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"ref_1","first-page":"1388","article-title":"Synchronous and Metachronous Cancers: An Update","volume":"2","author":"Das","year":"2017","journal-title":"Ann. Clin. Case Rep."},{"key":"ref_2","first-page":"69","article-title":"Triple synchronous primary gynaecological tumours. A case report","volume":"84","year":"2016","journal-title":"Cir. 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