{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:01:00Z","timestamp":1760144460383,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background: Lung cancer, particularly small-cell lung carcinoma (SCLC), often presents with respiratory symptoms. However, atypical manifestations including jaundice and abdominal pain can obscure the diagnosis, leading to challenges in early detection and treatment. Case Presentation: A 49-year-old male, with a history of smoking and diagnosed with Chronic Obstructive Pulmonary Disease (COPD), presented to the emergency department with a 3-day history of jaundice and a 3-week duration of mild abdominal pain. Initial investigations, including blood tests, showed hyperbilirubinemia and elevated lipase and amylase levels. An abdominal ultrasound was performed and revealed a hypoechoic, inhomogeneous mass in the head of the pancreas and multiple liver masses, suggesting a cephalo-pancreatic formation with liver metastasis. Further diagnostic procedures, including upper endoscopy and ERCP, followed by a TAP CT scan, identified a large mediastinal-pulmonary mass with invasion into major vessels and extensive metastasis. The immunohistochemical analysis of a duodenal ulcer biopsy confirmed a diagnosis of duodenal metastasis from a small-cell neuroendocrine lung carcinoma. Conclusion: Our case highlights that while rare, the possibility of metastatic spread should be included in the differential diagnosis when obstructive jaundice occurs in the context of high-risk factors for lung cancer.<\/jats:p>","DOI":"10.3390\/reports7020030","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T03:56:31Z","timestamp":1713930991000},"page":"30","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complex Presentation of Lung Cancer with Obstructive Jaundice"],"prefix":"10.3390","volume":"7","author":[{"given":"Ruxandra","family":"Oprita","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 050474 Bucharest, Romania"},{"name":"Gastroenterology Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Oprita","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 050474 Bucharest, Romania"},{"name":"Emergency Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana Adriana","family":"Serban","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia Aurelia","family":"Stefan","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciprian Mihai","family":"Neacsu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Elena","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Enache","sequence":"additional","affiliation":[{"name":"Pathology Department, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","first-page":"1243","article-title":"The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification","volume":"10","author":"Travis","year":"2015","journal-title":"J. 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Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e400S","DOI":"10.1378\/chest.12-2363","article-title":"Treatment of small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Jett","year":"2013","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e142S","DOI":"10.1378\/chest.12-2353","article-title":"Establishing the diagnosis of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Rivera","year":"2013","journal-title":"Chest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/archsurg.133.4.413","article-title":"Metastases to the pancreas and their surgical extirpation","volume":"133","author":"Castillo","year":"1998","journal-title":"Arch. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.3748\/wjg.v17.i43.4747","article-title":"Pancreatic metastases from renal cell carcinoma: The state of the art","volume":"17","author":"Ballarin","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3393\/ac.2019.11.13","article-title":"A Review of the Role of Carcinoembryonic Antigen in Clinical Practice","volume":"35","author":"Hall","year":"2019","journal-title":"Ann. Coloproctol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1111\/cas.15561","article-title":"CT and CEA-based machine learning model for predicting malignant pulmonary nodules","volume":"113","author":"Liu","year":"2022","journal-title":"Cancer Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1106525","DOI":"10.3389\/fonc.2022.1106525","article-title":"A nomogram diagnostic prediction model of pancreatic metastases of small cell lung carcinoma based on clinical characteristics, radiological features and biomarkers","volume":"12","author":"Xu","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_10","first-page":"2881","article-title":"Patterns of pancreatic metastasis from lung cancer","volume":"18","author":"Maeno","year":"1998","journal-title":"Anticancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"vii65","DOI":"10.1093\/annonc\/mdq380","article-title":"Advances in neuroendocrine lung tumors","volume":"21","author":"Travis","year":"2010","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. 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