{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:34:10Z","timestamp":1760146450866,"version":"build-2065373602"},"reference-count":8,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>A healthy 54-year-old man previously presented to vascular surgeons with a 4-year history of swelling of the penis and scrotum was scheduled for ultrasound evaluation in the angiology office in our department. At presentation, there was a giant enlargement of the penis and scrotum, without swelling of the legs. Ultrasound evaluation was negative for vascular abnormalities. A diagnosis of chronic lymphatic disease was suspected; thus, a lymphoscintigraphy was performed. This test was normal showing, a good visualization of major lymphatics. The patients had a history of psoriasis with a documented previous event of flexural psoriasis involving his genitals with secondary infection 4 years before. Since that infection, his genitals progressively increased in size, and despite medical treatment and different surgical evaluations, the patient\u2019s symptoms have not resolved, with marked disability associated with walking and sexual activity.<\/jats:p>","DOI":"10.3390\/reports7040092","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T07:47:16Z","timestamp":1730965636000},"page":"92","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unexplained Giant Genital Enlargement: Is It Due to Inverse Psoriasis?"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-6033","authenticated-orcid":false,"given":"Francesco","family":"Natale","sequence":"first","affiliation":[{"name":"Vanvitelli Cardiology and Intesive Care Unit, Monaldi Hospital, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3802-7052","authenticated-orcid":false,"given":"Giovanni","family":"Cimmino","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliera Universitaria Luigi Vanvitelli, 80138 Napoli, Italy"},{"name":"Department of Translational Medical Sciences, Section of Cardiology, University of Campania Luigi Vanvitelli, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.anplas.2023.03.005","article-title":"Genital elephantiasis in men","volume":"69","author":"Koualla","year":"2024","journal-title":"Ann. 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A Case Report","volume":"8","author":"Vishwanath","year":"2021","journal-title":"Dermatopathology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1093\/eurheartj\/ehae178","article-title":"2024 ESC Guidelines for the management of elevated blood pressure and hypertension","volume":"45","author":"McEvoy","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/JCMA.0000000000001021","article-title":"Genital elephantiasis: Surgical treatment and reconstruction","volume":"87","author":"Sun","year":"2023","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"E747","DOI":"10.1503\/cmaj.180262","article-title":"Psoriasis localized to the glans penis in a 37-year-old man","volume":"190","author":"Yao","year":"2018","journal-title":"Can. Med. Assoc. 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