{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:27:22Z","timestamp":1791638842234,"version":"4.3.4"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Among the odontogenic tumors, ameloblastoma is one of the most notorious, although it remains relatively rare, accounting for approximately one percent of all oral tumors. This neoplasm, derived from odontogenic epithelium, may arise from the developing enamel organ, epithelial cell rests of dental lamina, epithelial lining of odontogenic cysts, and basal cells of oral epithelium. This is a case presentation of a mural unicystic ameloblastoma, the most aggressive subtype and the one with the highest chance of recurrence. Case Presentation: A patient was referred by his dentist for root canal treatment at the Emergency Dental Clinic of Boston University. The patient complained of mandibular numbness. A panoramic radiograph was acquired, revealing a radiolucent lesion in the right mandible. Clinical examination detected a soft swelling perforating the buccal cortex in the area of #27\u2013#30. A Cone-Beam CT (CBCT) was acquired in the Oral and Maxillofacial Radiology Clinic revealing a well-defined, partially corticated entity in the periapical area of teeth #27 through #30, with evidence of scalloping borders. The internal structure was unilocular and uniformly low-density. The entity caused interruption of the lamina dura of the associated teeth and inferior displacement of the inferior alveolar canal. Differential diagnoses included unicystic ameloblastoma (UA) and central giant cell granuloma as a second less likely diagnosis. An incisional biopsy was performed for further evaluation. Biopsy confirmed UA with mural involvement. Conclusions: UAs typically exhibit less aggressive behavior. However, cases like this one, where mural involvement is noted and no associated impaction is detected, underline the possibility of variable radiographic presentation and the significance of a multidisciplinary approach in correct diagnosis and treatment. Histological subtyping is crucial for guiding treatment.<\/jats:p>","DOI":"10.3390\/reports7040093","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T07:47:16Z","timestamp":1730965636000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mural Unicystic Ameloblastoma of the Mandible: A Case Report"],"prefix":"10.3390","volume":"7","author":[{"given":"Mina","family":"Al Azawi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3354-1369","authenticated-orcid":false,"given":"Nikolaos","family":"Shinas","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-4220","authenticated-orcid":false,"given":"Vasileios","family":"Zisis","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Pathology, Dental School, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3413-124X","authenticated-orcid":false,"given":"Dhurata","family":"Shosho","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6611-7506","authenticated-orcid":false,"given":"Athanasios","family":"Poulopoulos","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Pathology, Dental School, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeba","family":"Kashtwari","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s42047-019-0041-z","article-title":"Ameloblastomas: Current Aspects of the New WHO Classification in an Analysis of 136 Cases","volume":"2","author":"Cadavid","year":"2019","journal-title":"Surg. Exp. Pathol."},{"key":"ref_2","first-page":"168","article-title":"The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition","volume":"38","author":"Wright","year":"2022","journal-title":"Turk. J. Pathol."},{"key":"ref_3","first-page":"ZC102","article-title":"Analysis of Prevalence and Clinical Features of Ameloblastoma and Its Histopathological Subtypes in Southeast Myanmar and Lower Northern Thailand Populations: A 13-Year Retrospective Study","volume":"11","author":"Intapa","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/0972-1363.143687","article-title":"Prevalence of Ameloblastoma: A Three-Year Retrospective Study","volume":"26","author":"Tatapudi","year":"2014","journal-title":"J. Indian Acad. Oral Med. Radiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/ijom.2003.0496","article-title":"Unicystic Ameloblastoma\u2014Use of Carnoy\u2019s Solution after Enucleation","volume":"33","author":"Lee","year":"2004","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1034\/j.1600-0714.2003.00118.x","article-title":"Dentigerous Cyst versus Unicystic Ameloblastoma\u2014Differential Diagnosis in Routine Histology","volume":"32","author":"Dunsche","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/0975-5950.94472","article-title":"Maxillary Unicystic Ameloblastoma: A Review of the Literature","volume":"2","author":"Singh","year":"2011","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1600-0714.1988.tb01331.x","article-title":"The Unicystic Ameloblastoma: A Clinicopathological Study of 57 Cases.: EBSCOhost","volume":"17","author":"Ackermann","year":"1988","journal-title":"J. Oral Pathol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.oraloncology.2005.10.001","article-title":"Usefulness of Contrast Enhanced-MRI in the Diagnosis of Unicystic Ameloblastoma","volume":"42","author":"Konouchi","year":"2006","journal-title":"Oral Oncol."},{"key":"ref_10","first-page":"e2735","article-title":"Radiographic Diagnosis of a Central Giant Cell Granuloma Using Advanced Imaging: Cone Beam Computed Tomography","volume":"10","author":"Abdelkarim","year":"2018","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20200429","DOI":"10.1259\/dmfr.20200429","article-title":"Radiological Features of Central Giant Cell Granuloma: Comparative Study of 7 Cases and Literature Review","volume":"50","author":"Shrestha","year":"2021","journal-title":"Dentomaxillofacial Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1002\/1097-0142(197711)40:5<2278::AID-CNCR2820400539>3.0.CO;2-L","article-title":"Unicystig Ameloblastoma. A Prognostically Distinct Entity","volume":"40","author":"Robinson","year":"1977","journal-title":"Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/jop.13453","article-title":"A conservative approach for unicystic ameloblastoma: Retrospective clinic-pathologic analysis of 12 cases","volume":"52","author":"Fonseca","year":"2023","journal-title":"J. Oral Pathol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1067\/moe.2001.114160","article-title":"Ameloblastoma: A Clinical, Radiographic, and Histopathologic Analysis of 71 Cases","volume":"91","author":"Kim","year":"2001","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1902\/jop.2007.060417","article-title":"Piezosurgical Treatment of Unicystic Ameloblastoma","volume":"78","author":"Covani","year":"2007","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/jop.12740","article-title":"Unicystic Ameloblastoma: Analysis of 370 Cases in a Single Center in Sri Lanka","volume":"47","author":"Siriwardena","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.15171\/joddd.2015.036","article-title":"Unicystic Ameloblastoma Presenting as a Multilocular Radiolucency in the Anterior Mandible: A Case Report","volume":"9","author":"Nigel","year":"2015","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospect."},{"key":"ref_18","first-page":"e27734","article-title":"Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor","volume":"14","author":"Ghai","year":"2022","journal-title":"Cureus"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/0976-237X.132305","article-title":"Ameloblastoma: A Clinicoradiographic and Histopathologic Correlation of 11 Cases Seen in Goa during 2008\u20132012","volume":"5","author":"Figueiredo","year":"2014","journal-title":"Contemp. Clin. Dent."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/7\/4\/93\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:27:45Z","timestamp":1760113665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/7\/4\/93"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["reports7040093"],"URL":"https:\/\/doi.org\/10.3390\/reports7040093","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]}}}