{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:03:17Z","timestamp":1780329797671,"version":"3.54.1"},"reference-count":13,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"Medical Scientist Training Program at the Leonard M. Miller School of Medicine, University of Miami","doi-asserted-by":"publisher","award":["5T32GM145462-03"],"award-info":[{"award-number":["5T32GM145462-03"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: A brain abscess, defined as a localized intracranial infection that evolves into a purulent collection encased by a vascularized capsule, has higher prevalence among immunocompromised populations. Patients with sickle cell disease (SCD) are particularly vulnerable to bacterial infections due to their compromised immune systems, increasing their susceptibility to pathogens like Salmonella. While Salmonella is typically associated with gastroenteritis, osteomyelitis, and septicemia, its involvement in brain abscesses is exceedingly rare. There are few documented cases of Salmonella brain abscesses in the general population, and among patients with SCD, only one such case has been reported to date. In this report, we describe the second known case of a brain abscess caused by Salmonella infection in a patient with sickle cell disease, contributing to the limited literature on this rare and life-threatening condition. Case Presentation: A 32-year-old African American woman with sickle cell disease presented to the ER after a generalized seizure, reporting two weeks of worsening headaches, fevers, and left upper extremity weakness. Imaging revealed a right frontoparietal brain abscess, which was surgically drained, and cultures identified Salmonella enterica. After antibiotic treatment and a 23-day hospital stay, she was discharged. Four months later, she returned with another seizure during a sickle cell crisis, but follow-up MRI showed only minor scarring, and she was discharged on anticonvulsant therapy. Conclusions: This case emphasizes that Salmonella infections, though typically linked to osteomyelitis and sepsis, can also cause brain abscesses in immunocompromised patients like those with sickle cell disease. It highlights the need to consider infections alongside vascular causes in acute neurological cases and underscores the value of a multidisciplinary approach in managing such complex conditions.<\/jats:p>","DOI":"10.3390\/reports7040107","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:20:12Z","timestamp":1732681212000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Salmonella Brain Abscess in Sickle Cell Disease Patient: Case Report"],"prefix":"10.3390","volume":"7","author":[{"given":"Felipe M. R.","family":"Monteiro","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-5799","authenticated-orcid":false,"given":"Ryan P.","family":"O\u2019Boyle","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny L.","family":"John","sequence":"additional","affiliation":[{"name":"Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-4558","authenticated-orcid":false,"given":"Guilherme S.","family":"Piedade","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joacir G.","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pcl.2021.09.007","article-title":"Salmonellosis Including Enteric Fever","volume":"69","author":"Qamar","year":"2022","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jama.2022.10233","article-title":"Sickle Cell Disease: A Review","volume":"328","author":"Kavanagh","year":"2022","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101118","DOI":"10.1016\/j.genrep.2021.101118","article-title":"Mini Review Salmonella: A Problem in Patients with Sickle Cell Anemia","volume":"23","author":"Boroujeni","year":"2021","journal-title":"Gene Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000048342","article-title":"Intracranial Salmonella Infections: Meningitis, Subdural Collections and Brain Abscess","volume":"36","author":"Mahapatra","year":"2002","journal-title":"Pediatr. Neurosurg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijid.2007.02.004","article-title":"Salmonella Enteritidis Brain Abscess in a Sickle Cell Disease Patient: Case Report and Review of the Literature","volume":"12","author":"Kuruvath","year":"2008","journal-title":"Int. J. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1182\/asheducation-2001.1.31","article-title":"Sickle Cell and the Brain","volume":"2001","author":"Adams","year":"2001","journal-title":"Hematology"},{"key":"ref_7","first-page":"102","article-title":"Neurological Complications of Sickle Cell Disease in Children in Yaound\u00e9 (Cameroon)","volume":"10","author":"Enyama","year":"2024","journal-title":"J. Med. Res."},{"key":"ref_8","unstructured":"Winn, H.R., and Youmans, J.R. (2017). Youmans and Winn Neurological Surgery: Fully, Searchable Text Online, Elsevier. [7th\u20138th ed.]."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1056\/NEJMra1301635","article-title":"Brain Abscess","volume":"371","author":"Brouwer","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1212\/WNL.0000000000000172","article-title":"Clinical Characteristics and Outcome of Brain Abscess: Systematic Review and Meta-Analysis","volume":"82","author":"Brouwer","year":"2014","journal-title":"Neurology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cmi.2023.08.016","article-title":"European Society of Clinical Microbiology and Infectious Diseases Guidelines on Diagnosis and Treatment of Brain Abscess in Children and Adults","volume":"30","author":"Bodilsen","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.crad.2014.04.012","article-title":"Can Diffusion-Weighted Imaging Be Used to Differentiate Brain Abscess from Other Ring-Enhancing Brain Lesions? A Meta-Analysis","volume":"69","author":"Xu","year":"2014","journal-title":"Clin. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1611","DOI":"10.1212\/WNL.0000000000206866","article-title":"Risk Factors and Prognosis of Epilepsy Following Brain Abscess: A Nationwide Population-Based Cohort Study","volume":"100","author":"Bodilsen","year":"2023","journal-title":"Neurology"}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/7\/4\/107\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:40:17Z","timestamp":1760114417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/7\/4\/107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["reports7040107"],"URL":"https:\/\/doi.org\/10.3390\/reports7040107","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]}}}