{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:18:28Z","timestamp":1785604708808,"version":"3.56.0"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Neuroendocrine expressing goblet cell adenocarcinomas (GCAs) are uncommon clinically aggressive tumours of the digestive system, originating almost exclusively in the ileocecal appendix. GCA\u2019s singularity comes from its amphicrine nature, expressing both neuroendocrine and exocrine characteristics. The case report\u2019s objective is to raise awareness of this neoplasia\u2019s possible extra-appendiceal localisation by showcasing a GCA involving the cecum with no detectable appendiceal tumour. Case Presentation: The authors present a case of GCA with neuroendocrine expression in an 82-year-old male patient with severe anaemia and comorbidities who underwent a right colectomy and had no histopathological evidence of appendiceal tumour involvement. Immunohistochemical testing was performed using synaptophysin, chromogranin A, neuronal specific enolase, CD56, CDX-2, CK20, CEA, MUC2 and Ki67, thus establishing the final diagnosis of high-grade extra-appendiceal goblet-cell adenocarcinoma of the cecum, G3. The patient died on postoperative day 26 due to pneumonia and acute renal failure in a chronic renal disease context. Conclusions: Extremely few cases of extra-appendiceal GCA have been reported. Appendiceal evaluation with the exclusion of this possible origin should be mandatory in such cases for a correct classification. These tumours do not benefit from any official management protocols concerning clinical evaluation, and their treatment is commonly based on the tumour\u2019s stage, as in classical adenocarcinoma.<\/jats:p>","DOI":"10.3390\/reports8010001","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T19:33:07Z","timestamp":1735241587000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Extra-Appendiceal Neuroendocrine Expressing Goblet Cell Adenocarcinoma of the Cecum\u2014A Case Report and Brief Review of the Literature"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-4289","authenticated-orcid":false,"given":"Alexandra","family":"Dinu","sequence":"first","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900573 Constan\u0163a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"A\u015fchie","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900573 Constan\u0163a, Romania"},{"name":"Faculty of Medicine, \u201dOvidius\u201d University of Constan\u0163a, 900591 Constan\u0163a, Romania"},{"name":"Department of Anatomy, Academy of Medical Sciences of Romania, 030171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Isabela","family":"B\u0103l\u0163\u0103tescu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology\u2014CEDMOG, \u201cOvidius\u201d University of Constan\u0163a, 900591 Constan\u0163a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-7280","authenticated-orcid":false,"given":"Manuela","family":"Enciu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Faculty of Medicine, \u201dOvidius\u201d University of Constan\u0163a, 900591 Constan\u0163a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionu\u0163","family":"Burlacu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900573 Constan\u0163a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e6822","DOI":"10.1002\/ccr3.6822","article-title":"Goblet cell adenocarcinoma of the ascending colon: An underrecognized diagnostic pitfall","volume":"11","author":"Limaiem","year":"2023","journal-title":"Clin. Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/jso.21863","article-title":"Goblet cell carcinoids at extraappendiceal locations of gastrointestinal tract: An underrecognized diagnostic pitfall","volume":"103","author":"Gui","year":"2011","journal-title":"J. Surg. 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