{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:12:25Z","timestamp":1760058745913,"version":"build-2065373602"},"reference-count":8,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Neonatal hemochromatosis is a rare iron overload disorder that causes severe liver injury in newborns, typically with extrahepatic siderosis. Diagnosis of neonatal hemochromatosis is usually confirmed through a biopsy and MRI, demonstrating deposition of iron and liver failure. However, in severe patients who are not able to undergo biopsy, the diagnostic and management method remains unknown. Case Presentation: We present an unusual case of neonatal hemochromatosis without extrahepatic iron deposition in a 9-day-old male who showed signs of liver failure and respiratory distress. This case suggests that when the risks of biopsy outweigh its benefits, a diagnosis may be reached based on clinical evaluation and MRI findings. Early high-dose intravenous immunoglobulin therapy improved liver function and led to recovery, highlighting the need for early therapeutic intervention in neonatal hemochromatosis. Conclusions: This case highlights that the absence of extrahepatic siderosis cannot exclude a diagnosis of neonatal hemochromatosis, and high doses of IVIG should be administered promptly when neonatal hemochromatosis is suspected to maximize therapeutic effectiveness.<\/jats:p>","DOI":"10.3390\/reports8020053","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T03:43:37Z","timestamp":1745379817000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful IVIG Treatment in Neonatal Hemochromatosis Without Extrahepatic Siderosis: A Case Report"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2976-4135","authenticated-orcid":false,"given":"Gwan Yong","family":"Lim","sequence":"first","affiliation":[{"name":"Anesthesiology and Intensive Care Scientific Circle, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0768-8353","authenticated-orcid":false,"given":"Ashta","family":"Thashin","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care Scientific Circle, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8429-917X","authenticated-orcid":false,"given":"Gayathri","family":"Joy","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care Scientific Circle, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2688-0487","authenticated-orcid":false,"given":"Ithamar","family":"Cheyne","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care Scientific Circle, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-7817","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Mikaszewska-Sokolewicz","sequence":"additional","affiliation":[{"name":"Clinic of Anesthesiology and Intensive Care, The Children\u2019s Memorial Health Institute, 04-730 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jceh.2013.10.004","article-title":"Neonatal hemochromatosis","volume":"3","author":"Feldman","year":"2013","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e1615","DOI":"10.1542\/peds.2007-3107","article-title":"Outcome of pregnancies at risk for neonatal hemochromatosis is improved by treatment with high-dose intravenous immunoglobulin","volume":"121","author":"Whitington","year":"2008","journal-title":"Pediatrics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jpeds.2014.09.030","article-title":"Neonatal hemochromatosis: Diagnostic work-up based on a series of 56 cases of fetal death and neonatal liver failure","volume":"166","author":"Heissat","year":"2015","journal-title":"J. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1076","DOI":"10.1542\/peds.2011-0568","article-title":"Neonatal liver cirrhosis without iron overload caused by gestational alloimmune liver disease","volume":"129","author":"Debray","year":"2012","journal-title":"Pediatrics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/hepr.12381","article-title":"Neonatal liver failure owing to gestational alloimmune liver disease without iron overload","volume":"45","author":"Tsunoda","year":"2015","journal-title":"Hepatol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00247-021-05008-9","article-title":"Magnetic resonance imaging of neonatal hemochromatosis","volume":"52","author":"Chavhan","year":"2022","journal-title":"Pediatr. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Staicu, A., Popa-Stanila, R., Albu, C., Constantin, R., Boitor-Borza, D., Surcel, M., Rotar, I.C., Cruciat, G., and Muresan, D. (2023). Neonatal Hemochromatosis: Systematic review of prenatal ultrasound findings\u2014Is there a place for MRI in the diagnostic process?. JCM, 12.","DOI":"10.3390\/jcm12072679"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jpeds.2009.04.012","article-title":"Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin","volume":"155","author":"Rand","year":"2009","journal-title":"J. Pediatr."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/2\/53\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:19:43Z","timestamp":1760030383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/2\/53"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["reports8020053"],"URL":"https:\/\/doi.org\/10.3390\/reports8020053","relation":{},"ISSN":["2571-841X"],"issn-type":[{"type":"electronic","value":"2571-841X"}],"subject":[],"published":{"date-parts":[[2025,4,23]]}}}