{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:56:56Z","timestamp":1773471416761,"version":"3.50.1"},"reference-count":11,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic syndrome characterized by bilateral uveal melanocyte proliferation and progressive visual disturbance. While most commonly associated with solid tumors, its occurrence in hematologic malignancies is exceedingly rare. Case Presentation: We report a case of BDUMP in a 64-year-old male recently diagnosed with chronic myelomonocytic leukemia (CMML), who presented with subacute, painless bilateral blurred vision. Multimodal imaging revealed suggestive features of BDUMP, including orange-red subretinal patches, retinal pigment epithelium mottling, and diffuse choroidal thickening, consistent with early structural involvement despite preserved central vision. No intraocular mass or signs of inflammation were observed. The patient did not receive specific treatment for BDUMP, and visual acuity remained stable during follow-up. Conclusions: This case underscores the importance of considering BDUMP in the differential diagnosis of bilateral visual symptoms in patients with hematologic malignancies. Although rare, BDUMP may occur in the context of CMML. Recognition through multimodal imaging and interdisciplinary collaboration is essential, and further research is needed to clarify its pathogenesis and improve management strategies.<\/jats:p>","DOI":"10.3390\/reports8030114","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:56:14Z","timestamp":1753084574000},"page":"114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bilateral Diffuse Uveal Melanocytic Proliferation in a Patient with Chronic Myelomonocytic Leukemia: A Rare Case and Literature Review"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5707-0972","authenticated-orcid":false,"given":"Dolika D.","family":"Vasovi\u0107","sequence":"first","affiliation":[{"name":"University Clinical Centre of Serbia, Eye Hospital, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-3890","authenticated-orcid":false,"given":"Miodrag Lj.","family":"Karamarkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Jeremi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre of Serbia, Eye Hospital, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan M.","family":"Ra\u0161i\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre of Serbia, Eye Hospital, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/archopht.1990.01070060075053","article-title":"Bilateral diffuse uveal melanocytic proliferation in patients with occult carcinoma","volume":"108","author":"Gass","year":"1990","journal-title":"Arch. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.survophthal.2003.08.005","article-title":"Bilateral diffuse uveal melanocytic proliferation associated with pancreatic carcinoma: A case report and literature review of this paraneoplastic syndrome","volume":"48","author":"Butnor","year":"2003","journal-title":"Surv. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pefkianaki, M., Agrawal, R., Desai, P., Pavesio, C., and Sagoo, M.S. (2015). Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP) associated with B-cell lymphoma: Report of a rare case. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1020-8"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/aos.13481","article-title":"Bilateral diffuse uveal melanocytic proliferation: Case report and literature review","volume":"95","author":"Klemp","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"10732748221144458","DOI":"10.1177\/10732748221144458","article-title":"Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy","volume":"29","author":"Weppelmann","year":"2022","journal-title":"Cancer Control"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40942-016-0038-7","article-title":"Multimodal imaging of bilateral diffuse uveal melanocytic proliferation associated with an iris mass lesion","volume":"2","author":"Naysan","year":"2016","journal-title":"Int. J. Retina Vitreous"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Draca, N., Ore\u0161kovi\u0107, E.G., Lazi\u0107, R., Vukojevi\u0107, M., Radolovi\u0107 Berteti\u0107, A., and Vukojevi\u0107, N. (2023). Management of Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP)\u2014A Case Report. Medicina, 59.","DOI":"10.20944\/preprints202310.1066.v1"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101582","DOI":"10.1016\/j.ajoc.2022.101582","article-title":"Presumed bilateral diffuse uveal melanocytic proliferation\u2014A case report and review of literature","volume":"27","author":"Parakh","year":"2022","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rafei-Shamsabadi, D., Schneider, J., Trefzer, L., Technau-Hafsi, K., Meiss, F., and Ness, T. (2021). Case Report: Blurred Vision and Eruptive Nevi\u2014Bilateral Diffuse Uveal Melanocytic Proliferation With Mucocutaneous Involvement in a Lung Cancer Patient. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.658407"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tong, N., Wang, L., Wang, N., and Zhou, Z. (2021). Bilateral Diffuse Uveal Melanocytic Proliferation Secondary to Rectal Adenocarcinoma: A Case Report and Literature Review. Front. Med., 8.","DOI":"10.3389\/fmed.2021.691686"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3928\/15428877-20100426-05","article-title":"Loss of Retinal Pigment Epithelium Associated with Bilateral Diffuse Uveal Melanocytic Proliferation: A Case Report","volume":"41","author":"Kiratli","year":"2010","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/3\/114\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:12:33Z","timestamp":1760033553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/3\/114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,19]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["reports8030114"],"URL":"https:\/\/doi.org\/10.3390\/reports8030114","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,19]]}}}