{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:45:25Z","timestamp":1788432325752,"version":"build-2803163510"},"reference-count":18,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria","award":["BG-RRP-2.004-0009-C02"],"award-info":[{"award-number":["BG-RRP-2.004-0009-C02"]}]},{"name":"Medical University\u2014Varna","award":["BG-RRP-2.004-0009-C02"],"award-info":[{"award-number":["BG-RRP-2.004-0009-C02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and clinical significance: Trichoblastomas are rare, mixed epithelial tumors with a mesenchymal component and hair follicle differentiation. Case presentation: Herein, we present a case report of a 51-year-old female patient presenting to the obstetrics and gynecology department with complaints of edema and erythema of the right Bartholin gland, and a lesion measuring 2 cm on the right lateral edge of the mons pubis, towards the inguinal fold. Marsupialization of the Bartholin gland was performed, as well as an incision into the pubo-inguinal lesion, which the patient depicted as grossly resembling an ingrown hair. Upon incision into the pubic\u2013inguinal lesion, it was dark brown in color and spontaneously popped out of the subcutis, without an attempt at enucleation. Histology and subsequent immunohistochemistry of the lesion showed a blue basaloid tumor with an extensive pigment component located deep in the dermis that was sharply demarcated from the surrounding tissues. Conclusion: Immunohistochemistry was diffusely and strongly positive for epithelial markers; melanocytic markers were positive only in dendritic melanocytes dispersed within the tumors, and the proliferative index was low. As such, the tumor was identified as melanotrichoblastoma.<\/jats:p>","DOI":"10.3390\/reports8030130","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T09:41:17Z","timestamp":1754300477000},"page":"130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Melanotrichoblastoma: A Histopathological Case Report of a Rare Pigmented Variant of Trichoblastoma"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-0615","authenticated-orcid":false,"given":"George S.","family":"Stoyanov","sequence":"first","affiliation":[{"name":"Department of Pathology, Multiprofile Hospital for Active Treatment, 9700 Shumen, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivaylo","family":"Balabanov","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Multiprofile Hospital for Active Treatment, 9700 Shumen, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetoslava","family":"Zhivkova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Multiprofile Hospital for Active Treatment, 9700 Shumen, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hristo","family":"Popov","sequence":"additional","affiliation":[{"name":"Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University\u2014Varna, 9002 Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref_1","unstructured":"Schukow, C., and Ahmed, A. (2023). Trichoblastoma and Trichoepithelioma, StatPearls."},{"key":"ref_2","first-page":"e8272","article-title":"Trichoblastomas Mimicking Basal Cell Carcinoma: The Importance of Identification and Differentiation","volume":"12","author":"Patel","year":"2020","journal-title":"Cureus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4103\/ijd.ijd_416_21","article-title":"Expression of BerEP4 and CD10 IHC Markers in Basal Cell Carcinoma, Squamous Cell Carcinoma and Adnexal Tumours of Follicular Differentiation: A Comparative Study","volume":"68","author":"Shabeer","year":"2023","journal-title":"Indian J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/00000372-200212000-00008","article-title":"Melanotrichoblastoma: Immunohistochemical Study of a Variant of Pigmented Trichoblastoma","volume":"24","author":"Kanitakis","year":"2002","journal-title":"Am. J. Dermatopathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.abd.2022.07.011","article-title":"Melanotrichoblastoma: Sixth Case Report in the Literature","volume":"98","year":"2023","journal-title":"An. Bras. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1097\/DAD.0b013e3181dfd120","article-title":"Giant Melanotrichoblastoma","volume":"33","author":"Kim","year":"2011","journal-title":"Am. J. Dermatopathol."},{"key":"ref_7","first-page":"243","article-title":"Melanotrichoblastoma: A Rare Pigmented Variant of Trichoblastoma-PubMed","volume":"100","author":"Quist","year":"2017","journal-title":"Cutis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1111\/ijd.15042","article-title":"The First Case of a Collision Tumor of Melanotrichoblastoma and Seborrheic Keratosis","volume":"60","author":"Mizuta","year":"2021","journal-title":"Int. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4103\/0378-6323.100544","article-title":"Ripple-Pattern Melanotrichoblastoma Arising within Nevus Sebaceus","volume":"78","author":"Hung","year":"2012","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/ijd.ijd_1197_23","article-title":"Melanotrichoblastoma Arising on Nevus Sebaceous: A Rare Occurence","volume":"70","author":"Thekho","year":"2025","journal-title":"Indian J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"666","DOI":"10.14744\/nci.2022.25675","article-title":"Ber-EP4 Staining Patterns on Basal Cell Carcinomas","volume":"10","author":"Ozkanli","year":"2023","journal-title":"North. Clin. Istanb."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1016\/j.pathol.2018.12.272","article-title":"Malignant Basomelanocytic Tumour: A Case Report","volume":"51","author":"Tanzifi","year":"2019","journal-title":"Pathology"},{"key":"ref_13","first-page":"e36907","article-title":"Melanocytic Matricoma: A Potential Mimic of Malignant Melanoma","volume":"15","author":"Yablonski","year":"2023","journal-title":"Cureus"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/01.pai.0000209868.58699.64","article-title":"The Significance of Ki-67 Proliferative Index and Cyclin D1 Expression of Dysplastic Nevi in the Biologic Spectrum of Melanocytic Lesions","volume":"15","author":"Lebe","year":"2007","journal-title":"Appl. Immunohistochem. Mol. 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Koirala Institute of Health Sciences, Dharan, Nepal","volume":"2","author":"Pokharel","year":"2017","journal-title":"Birat J. Health Sci."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/3\/130\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:20:57Z","timestamp":1760034057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/3\/130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["reports8030130"],"URL":"https:\/\/doi.org\/10.3390\/reports8030130","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}