{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:57:22Z","timestamp":1778324242046,"version":"3.51.4"},"reference-count":13,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Brugada syndrome (BrS) is a rare inherited cardiac channelopathy, often associated with SCN5A loss-of-function mutations. Clinical presentations range from asymptomatic to malignant arrhythmias and sudden cardiac death. Physiological and pharmacological stressors affecting sodium channel function\u2014such as pyrexia, certain medications, and possibly pregnancy\u2014may unmask or exacerbate arrhythmic risk. However, there is limited information regarding pregnancy and obstetric outcomes. Obstetric management remains largely informed by isolated case reports and small case series. A literature review was conducted using OVID Medline and Embase, identifying case reports, case series, and one retrospective cohort study reporting clinical presentation, obstetric management, and outcomes in maternal BrS. A case is presented detailing coordinated multidisciplinary input, antenatal surveillance, and intrapartum and postpartum care to contribute to the growing evidence base guiding obstetric care in this complex setting. Case Presentation: A 30-year-old G2P0 woman with asymptomatic BrS (SCN5A-positive) was referred at 31 + 5 weeks\u2019 gestation for multidisciplinary antenatal care. Regular review and collaborative planning involving cardiology, anaesthetics, maternal\u2013fetal medicine, and obstetrics guided a plan for vaginal delivery with continuous cardiac and fetal monitoring. At 38 + 0 weeks, the woman presented with spontaneous rupture of membranes and underwent induction of labour. A normal vaginal delivery was achieved without arrhythmic events. Epidural block with ropivacaine and local anaesthesia with lignocaine were well tolerated, and 24 h postpartum monitoring revealed no abnormalities. Conclusions: This case adds to the limited but growing literature suggesting that with individualised planning and multidisciplinary care, pregnancies in women with BrS can proceed safely and without complication. Ongoing case reporting is essential to inform future guidelines and optimise maternal and fetal outcomes.<\/jats:p>","DOI":"10.3390\/reports8030138","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T10:50:21Z","timestamp":1754391021000},"page":"138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multidisciplinary Care Approach to Asymptomatic Brugada Syndrome in Pregnancy: A Case Report"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-890X","authenticated-orcid":false,"given":"Isabella","family":"Marechal-Ross","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Royal North Shore Hospital, Clinical Services Building, 1 Westbourne St, St Leonards, NSW 2065, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Royal North Shore Hospital, Clinical Services Building, 1 Westbourne St, St Leonards, NSW 2065, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.recesp.2013.09.023","article-title":"Brugada syndrome and pregnancy: Delving into the role of sex hormones in ion channelopathies","volume":"67","author":"Benito","year":"2014","journal-title":"Rev. Esp. Cardiol. (Engl. Ed.)"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Xu, T., Wang, S., Wang, J., and Xing, J. (2024). Brugada syndrome update. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1520008"},{"key":"ref_3","first-page":"267","article-title":"Worldwide Prevalence of Brugada Syndrome: A Systematic Review and Meta-Analysis","volume":"34","author":"Vutthikraivit","year":"2018","journal-title":"Acta Cardiol. Sin."},{"key":"ref_4","first-page":"531648","article-title":"Brugada syndrome and pregnancy: Highlights on antenatal and prenatal management","volume":"2014","author":"Giambanco","year":"2014","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_5","first-page":"236","article-title":"Rethinking spinal anesthetic with bupivacaine for cesarean delivery in parturient with Brugada syndrome","volume":"73","author":"Yu","year":"2023","journal-title":"Braz. J. 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Electrophysiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/JOACC.JOACC_80_23","article-title":"Anesthesiology Approach to Pregnant Women Affected by Brugada Syndrome: A Single-Center Case Series and Literature Review","volume":"14","author":"Gualtieri","year":"2024","journal-title":"J. Obstet. Anaesth. Crit. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijoa.2010.10.006","article-title":"Caesarean section for twin pregnancy in a parturient with Brugada syndrome","volume":"20","author":"Bramall","year":"2011","journal-title":"Int. J. Obstet. Anesth."},{"key":"ref_11","first-page":"e18","article-title":"Electrical storm in Brugada syndrome during pregnancy","volume":"34","author":"Emkanjoo","year":"2011","journal-title":"Pacing Clin. 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Med., 9.","DOI":"10.3389\/fcvm.2022.874992"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.hrthm.2009.07.002","article-title":"Drugs and Brugada syndrome patients: Review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)","volume":"6","author":"Postema","year":"2009","journal-title":"Heart Rhythm"}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/3\/138\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:23:21Z","timestamp":1760034201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/3\/138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,5]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["reports8030138"],"URL":"https:\/\/doi.org\/10.3390\/reports8030138","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,5]]}}}