{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:38:17Z","timestamp":1760060297960,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Many women use pessaries to manage their symptoms of pelvic organ prolapse. Hydroxyquinoline is the active ingredient in gels and ointments that are often used to lubricate a pessary prior to vaginal insertion and to provide antimicrobial effects while the pessary is in situ. Case Presentation: A 74-year-old woman with multiple medication allergies develops vulvovaginal erythema and pruritus after increasing vaginal Trimo-San application frequency for pessary care and maintenance. These symptoms are deemed to be consistent with an allergic reaction to hydroxyquinoline, the active ingredient in Trimo-San. Conclusions: This report highlights the importance of personalized treatment in pessary management. It also demonstrates how personalized medicine can optimize outcomes and improve treatment adherence among individuals with complex medical histories.<\/jats:p>","DOI":"10.3390\/reports8030145","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T08:39:07Z","timestamp":1755247147000},"page":"145","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized Management of Hydroxyquinoline Hypersensitivity in Pessary Care: A Case-Based Approach to Tailored Treatment"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6324-1872","authenticated-orcid":false,"given":"Nadege","family":"Assassi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-1091","authenticated-orcid":false,"given":"Jill Maura","family":"Rabin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists, and American Urogynecologic Society (2019). Pelvic organ prolapse: ACOG practice bulletin, number 214. Female Pelvic Med. Reconstr. Surg., 25, 397\u2013408.","DOI":"10.1097\/SPV.0000000000000794"},{"key":"ref_2","unstructured":"Progetto Menopausa Italia Study Group (2000). Risk factors for genital prolapse in non-hysterectomized women around menopause. Results from a large cross-sectional study in menopausal clinics in Italy. Eur. J. Obstet. Gynecol. Reprod. Biol., 93, 135\u2013140."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00192-015-2695-8","article-title":"Risk factors for pelvic organ prolapse and its recurrence: A systematic review","volume":"26","author":"Vergeldt","year":"2015","journal-title":"Int. Urogynecol. J."},{"key":"ref_4","first-page":"CD001500","article-title":"Local oestrogen for vaginal atrophy in postmenopausal women","volume":"2016","author":"Lethaby","year":"2016","journal-title":"Cochrane Database Syst. 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Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3923\/ijp.2013.170.175","article-title":"Antimicrobial Activity of 8-Hydroxyquinoline and Transition Metal Complexes","volume":"9","author":"Srisung","year":"2013","journal-title":"Int. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/0140-6736(92)91710-P","article-title":"Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts","volume":"340","author":"Goldblum","year":"1992","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/DSS.0000000000001448","article-title":"Cutaneous Hypersensitivity-Like Reactions Associated with Breast Implants: A Review","volume":"44","author":"Labadie","year":"2018","journal-title":"Dermatol. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bugge, C., Adams, E.J., Gopinath, D., Stewart, F., Dembinsky, M., Sobiesuo, P., and Kearney, R. (2020). Pessaries (mechanical devices) for managing pelvic organ prolapse in women. Cochrane Database Syst. Rev., CD004010.","DOI":"10.1002\/14651858.CD004010.pub4"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/AOG.0000000000001489","article-title":"Vaginal Pessary in Women with Symptomatic Pelvic Organ Prolapse: A Randomized Controlled Trial","volume":"128","author":"Cheung","year":"2016","journal-title":"Obstet Gynecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/bco2.174","article-title":"Rare complications of pessary use: A systematic review of case reports","volume":"3","author":"Dabic","year":"2022","journal-title":"BJUI Compass"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/nau.24458","article-title":"Factors associated with unsuccessful pessary fitting in women with symptomatic pelvic organ prolapse: Systematic review and meta-analysis","volume":"39","author":"Brito","year":"2020","journal-title":"Neurourol. Urodyn."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/SPV.0000000000000520","article-title":"Changes in the Vaginal Microenvironment as Related to Frequency of Pessary Removal","volume":"24","author":"Fregosi","year":"2018","journal-title":"Female Pelvic Med. Reconstr. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4103\/idoj.IDOJ_280_20","article-title":"Hydroxychloroquine in Dermatology and Beyond: Recent Update","volume":"11","author":"Sardana","year":"2020","journal-title":"Indian Dermatol. Online J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2133.1995.tb06951.x","article-title":"Recurrent fixed drug eruption due to clioquinol","volume":"133","author":"Janier","year":"1995","journal-title":"Br. J. Dermatol."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/3\/145\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:28:02Z","timestamp":1760034482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/3\/145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["reports8030145"],"URL":"https:\/\/doi.org\/10.3390\/reports8030145","relation":{},"ISSN":["2571-841X"],"issn-type":[{"type":"electronic","value":"2571-841X"}],"subject":[],"published":{"date-parts":[[2025,8,15]]}}}