{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:33:54Z","timestamp":1783971234392,"version":"3.55.0"},"reference-count":18,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Retroperitoneal tumors are a rare and diverse group of neoplasms, accounting for less than 1% of adult solid tumors. Retroperitoneal lipomas are particularly uncommon, with fewer than 20 cases described in the literature. Their asymptomatic growth and lack of clear anatomical boundaries can result in delayed diagnosis and substantial tumor size at clinical presentation. This case highlights a rare retroperitoneal lipoma with atypical extension into the right thigh through the muscular lacuna, mimicking a femoral hernia and compressing the femoral nerve\u2014a presentation scarcely reported and clinically significant due to its surgical complexity and risk of recurrence. Case Presentation: We report the case of a 65-year-old woman from an urban setting who presented with progressive right thigh discomfort and lower limb pain during ambulation. The mass had been initially identified two years prior as a small, asymptomatic right inguinal formation during imaging to exclude an inguinal hernia. Computed tomography (CT) and magnetic resonance imaging (MRI) confirmed a large retroperitoneal lipomatous tumor extending to the anteromedial right thigh. Surgical excision was performed through a dual approach: midline laparotomy and thigh incision. A 30 \u00d7 30 cm encapsulated lipoma was removed without injuring adjacent nerves or vessels. Histopathological evaluation confirmed a mature lipoma without atypia but with a lipogranulomatous reaction. The patient\u2019s postoperative course was favorable, with minimal residual paresthesia and complete wound healing. Conclusions: Although benign, retroperitoneal lipomas can mimic other pathologies and present surgical challenges when they extend beyond their typical boundaries. Early recognition and coordinated surgical management are crucial for optimal outcomes and prevention of recurrence.<\/jats:p>","DOI":"10.3390\/reports8030181","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:00:00Z","timestamp":1758106800000},"page":"181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Asymptomatic Retroperitoneal Lipoma with Extension to the Right Anteromedial Thigh"],"prefix":"10.3390","volume":"8","author":[{"given":"Catalin","family":"Balta","sequence":"first","affiliation":[{"name":"County Emergency Clinical Hospital Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7608-4306","authenticated-orcid":false,"given":"Marian","family":"Botoncea","sequence":"additional","affiliation":[{"name":"County Emergency Clinical Hospital Targu Mures, 540136 Targu Mures, Romania"},{"name":"Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, 540253 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian","family":"Toma","sequence":"additional","affiliation":[{"name":"County Emergency Clinical Hospital Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rares","family":"Voda","sequence":"additional","affiliation":[{"name":"County Emergency Clinical Hospital Targu Mures, 540136 Targu Mures, Romania"},{"name":"Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, 540253 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Balta","sequence":"additional","affiliation":[{"name":"County Emergency Clinical Hospital Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmin","family":"Nicolescu","sequence":"additional","affiliation":[{"name":"County Emergency Clinical Hospital Targu Mures, 540136 Targu Mures, Romania"},{"name":"Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, 540253 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.3390\/curroncol29090504","article-title":"Updates in Pathology for Retroperitonal Soft Tissue Sarcoma","volume":"29","author":"Mack","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Trans-Atlantic RPS Working Group (2015). Management of primary retroperitoneal sarcoma (RPS) in the adult: A consensus approach from the Trans-Atlantic RPS Working Group. Ann. Surg. Oncol., 22, 256\u2013263.","DOI":"10.1245\/s10434-014-3965-2"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1245\/s10434-012-2342-2","article-title":"Technical Considerations in Surgery for Retroperitoneal Sarcomas: Position Paper from E-Surge, a Master Class in Sarcoma Surgery, and EORTC\u2013STBSG","volume":"19","author":"Bonvalot","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"de Bree, E., Michelakis, D., Heretis, I., Kontopodis, N., Spanakis, K., Lagoudaki, E., Tolia, M., Zografakis-Sfakianakis, M., Ioannou, C., and Mavroudis, D. (2023). Retroperitoneal Soft Tissue Sarcoma: Emerging Therapeutic Strategies. Cancers, 15.","DOI":"10.3390\/cancers15225469"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Weniger, M., D\u2019Haese, J.G., Kunz, W., Pratschke, S., Guba, M., Werner, J., and Angele, M.K. (2015). En-bloc resection of a giant retroperitoneal lipoma: A case report and review of the literature. BMC Res. Notes, 8.","DOI":"10.1186\/s13104-015-1038-7"},{"key":"ref_6","first-page":"893242","article-title":"Retroperitoneal lipoma presenting with nutcracker-like phenomenon","volume":"2013","author":"Saito","year":"2013","journal-title":"Case Rep. Urol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMicm1413283","article-title":"IMAGES IN CLINICAL MEDICINE. Constipation Associated with a Lipoma","volume":"373","author":"Hardy","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_8","first-page":"75","article-title":"Giant lipomas or retroperitoneal liposarcomas? Controversies in their diagnosis and treatment","volume":"54","author":"Gil","year":"2021","journal-title":"Rev. Esp. Patol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e239301","DOI":"10.1136\/bcr-2020-239301","article-title":"Resection of a giant retroperitoneal lipoma herniating through the inguinal canal","volume":"14","author":"Nardi","year":"2021","journal-title":"BMJ Case Rep."},{"key":"ref_10","first-page":"323","article-title":"Giant retroperitoneal liposarcoma: A case report","volume":"32","author":"Selmani","year":"2011","journal-title":"Prilozi"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.47162\/RJME.63.1.27","article-title":"Half abdomen tumor\u2014Giant retroperitoneal lipoma: A case report and review of the literature","volume":"63","author":"Petca","year":"2022","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111584","DOI":"10.1016\/j.ijscr.2025.111584","article-title":"Giant retroperitoneal lipoma resulting in femoral hernia: A case report","volume":"133","author":"Kotohata","year":"2025","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.12998\/wjcc.v10.i5.1675","article-title":"Giant retroperitoneal lipoma presenting with abdominal distention: A case report and review of the literature","volume":"10","author":"Chen","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s11864-013-0236-6","article-title":"The Role of Radiation in Retroperitoneal Sarcomas","volume":"14","author":"Mohindra","year":"2013","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.4081\/rt.2009.e13","article-title":"Retroperitoneal lipoma arising from the urinary bladder","volume":"1","author":"Ukita","year":"2009","journal-title":"Rare Tumors"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1748-717X-8-60","article-title":"Prognostic variables in patients with primary soft tissue sarcoma of the extremity and trunk treated with neoadjuvant radiotherapy or neoadjuvant sequential chemoradiotherapy","volume":"8","author":"Bedi","year":"2013","journal-title":"Radiat. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"rjac121","DOI":"10.1093\/jscr\/rjac121","article-title":"A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis","volume":"2022","author":"Laurens","year":"2022","journal-title":"J. Surg. Case Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nissen, T., and Wynn, R. (2014). The clinical case report: A review of its merits and limitations. BMC Res. 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