{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:25:51Z","timestamp":1791062751776,"version":"4.1.0"},"reference-count":11,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Lymphatic-venous malformations (LVMs) are uncommon congenital vascular anomalies with low blood flow, consisting of atypical connections between lymphatic and venous vessels. They may develop in different body regions, with a predilection for lymphatic-rich areas. Fewer than 5% of LVMs are located intra-abdominally, typically arising from the mesentery, retroperitoneum, or greater omentum. Patients with intra-abdominal LVMs may be asymptomatic, but they can also present with symptoms such as acute abdominal pain, chronic discomfort, palpable masses, or progressive abdominal distension. Case Presentation: This case describes a 24-year-old female who presented to our emergency department with progressive abdominal distension, nausea, and vomiting. Conclusions: The diagnosis of LVMs can be challenging and requires a combination of imaging techniques, including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI), along with histological confirmation.<\/jats:p>","DOI":"10.3390\/reports8030183","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:24:25Z","timestamp":1758198265000},"page":"183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of a Large Intra-Abdominal Lymphatic-Venous Malformation in a Young Woman Presenting to the Emergency Room with Abdominal Pain"],"prefix":"10.3390","volume":"8","author":[{"given":"Gloria","family":"Perillo","sequence":"first","affiliation":[{"name":"Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domiziana","family":"Santucci","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6110-6134","authenticated-orcid":false,"given":"Raffaele","family":"Ragone","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6968-0645","authenticated-orcid":false,"given":"Elva","family":"Vergantino","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2578-7523","authenticated-orcid":false,"given":"Stefania","family":"Lamja","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Celozzi","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Beomonte Zobel","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-6891","authenticated-orcid":false,"given":"Eliodoro","family":"Faiella","sequence":"additional","affiliation":[{"name":"Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.jvsv.2021.01.013","article-title":"Management of lymphatic vascular malformations: A systematic review of the literature","volume":"9","author":"Kalwani","year":"2021","journal-title":"J. Vasc. Surg. Venous. Lymphat. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.radcr.2020.10.052","article-title":"Intra-abdominal lymphangioma: A case report","volume":"16","author":"Shayesteh","year":"2021","journal-title":"Radiol Case Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101969","DOI":"10.1016\/j.jvsv.2024.101969","article-title":"Clinical characteristics and risk factors for acute abdomen in patients with abdominal lymphatic malformations","volume":"13","author":"Yang","year":"2024","journal-title":"J. Vasc. Surg. Venous. Lymphat. Disord."},{"key":"ref_4","first-page":"e113","article-title":"ISSVA Vascular Anomalies Classification Group. Updated Classification of Vascular Anomalies. A living document from the International Society for the Study of Vascular Anomalies Classification Group","volume":"6","author":"Goldenberg","year":"2025","journal-title":"J. Vasc. 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Surg."},{"key":"ref_10","first-page":"e72874","article-title":"Child Abdominal Distension Due to a Massive Retroperitoneal Lymphangioma: A Cyto-Histopathological and Clinical Correlation","volume":"16","author":"Morais","year":"2024","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"108275","DOI":"10.1016\/j.ijscr.2023.108275","article-title":"A rare case of huge intra-abdominal cystic lymphangioma arising from rectovesical pouch; a case report","volume":"106","author":"Abebe","year":"2023","journal-title":"Int. J. Surg. 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