{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:59:14Z","timestamp":1792630754876,"version":"4.5.0"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Mucinous tubular and spindle cell carcinoma (MTSCC) is an uncommon subtype of renal cell carcinoma, representing 1\u20134% of epithelial renal tumors. It usually shows a low-grade morphology and indolent behavior, although sarcomatoid variants with an aggressive course have been described. Because of its overlap with papillary renal cell carcinoma (papRCC), sarcomatoid RCC, mesenchymal tumors, and oncocytic neoplasms, diagnosis requires the integration of imaging, histopathology, and immunohistochemistry. Case Presentation: We report a 71-year-old female who presented with a three-month history of right-sided lumbar pain and intermittent hematuria. Her laboratory tests were unremarkable. Contrast-enhanced CT revealed a well-circumscribed nodular lesion in the mid-portion of the right kidney, measuring 50 \u00d7 47 \u00d7 52 mm. The patient underwent right nephrectomy. Macroscopic findings revealed an encapsulated, yellowish-gray nodule (5.2 \u00d7 5 \u00d7 4 cm) without renal pelvis invasion. Microscopically, the tumor consisted of cuboidal- to spindle-shaped cells arranged in cords and tubular structures within a mucinous stroma, with focal necrosis and foamy macrophages. Immunohistochemistry showed positivity for CK19, CK7, EMA, PAX8, and AMACR, with a Ki-67 index &lt;10%, while CD117, RCC, CD10, and chromogranin were negative. Together, the low Ki-67 proliferation index, absence of invasion, and low-grade histological architecture confirmed MTSCC of low malignant potential. At a five-year follow-up, the patient remained disease-free. Conclusions: MTSCC is a rare renal neoplasm that can be diagnosed by integrating clinico-radiological, histopathological, and immunophenotypic features. Molecular profiling may further distinguish MTSCC from papRCC and identify aggressive variants. Surgical excision remains the cornerstone of management, supported by vigilant long-term follow-up.<\/jats:p>","DOI":"10.3390\/reports8040189","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:32:53Z","timestamp":1758637973000},"page":"189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Rare Renal Neoplasm\u2014Case Report and Literature Review"],"prefix":"10.3390","volume":"8","author":[{"given":"Ionu\u0163","family":"Burlacu","sequence":"first","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900573 Constan\u0163a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"A\u015fchie","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900573 Constan\u0163a, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900527 Constan\u0163a, Romania"},{"name":"Department of Anatomy, Academy of Medical Sciences of Romania, 030171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u0103d\u0103lina","family":"Bo\u015foteanu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Faculty of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900527 Constan\u0163a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Izabela","family":"B\u0103l\u0163\u0103tescu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology\u2014CEDMOG, \u201cOvidius\u201d University of Constan\u0163a, 900591 Constan\u0163a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-4289","authenticated-orcid":false,"given":"Alexandra","family":"Dinu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSf. Apostol Andrei\u201d Emergency County Hospital, 900591 Constan\u0163a, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constan\u0163a, 900573 Constan\u0163a, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.eururo.2005.11.035","article-title":"2004 WHO classification of the renal tumors of the adults","volume":"49","author":"Scarpelli","year":"2006","journal-title":"Eur. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","article-title":"The 2016 WHO classification of tumours of the urinary system and male genital organs. Part A: Renal, penile, and testicular tumours","volume":"70","author":"Moch","year":"2016","journal-title":"Eur. 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