{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:31:24Z","timestamp":1762183884806,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EU NextGenerationEU","award":["09I03-03-V04-00211"],"award-info":[{"award-number":["09I03-03-V04-00211"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis in adults, typically following a chronic course that often leads to end-stage kidney disease. Rapidly progressive glomerulonephritis is a rare and severe variant of IgAN with a poor prognosis. Case Presentation: We present the clinical case of a 68-year-old Caucasian female with a history of systemic lupus erythematosus and untreated chronic hepatitis B, who was admitted to the Transplant-Nephrology Department, University Hospital Martin, with acute kidney injury and nephrotic syndrome accompanied by hematuria. The clinical picture was marked by lower limb oedema and poorly controlled hypertension, both of which responded well to conservative management. Extrarenal causes were excluded through otolaryngologic, stomatologic, and gynecologic assessments, and autoantibody screening was negative. Renal biopsy revealed crescentic glomerulonephritis with endocapillary and mesangial proliferation and IgA deposits. Due to active hepatitis B, initial treatment was limited to corticosteroids. Following a decrease in viral load, pulse therapy with cyclophosphamide was administered, followed by mycophenolic acid; however, renal function did not recover. Conclusions: The rapidly progressive form of IgA nephropathy in the context of active hepatitis B presents a rare and challenging clinical case. Management requires a highly individualised, multidisciplinary approach due to the risk of infectious complications and the need to preserve renal function.<\/jats:p>","DOI":"10.3390\/reports8040220","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:55:22Z","timestamp":1762178122000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapidly Progressive IgA Nephropathy in a Patient with Systemic Lupus Erythematosus and Chronic Hepatitis B: A Case Report"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5156-5226","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Kleinov\u00e1","sequence":"first","affiliation":[{"name":"Transplant-Nephrology Department, University Hospital Martin, Koll\u00e1rova 2, 036 01 Martin, Slovakia"},{"name":"Department of Internal Medicine I, Jessenius Medical Faculty, Comenius University, 036 01 Martin, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-0365","authenticated-orcid":false,"given":"Karol","family":"Gra\u0148\u00e1k","sequence":"additional","affiliation":[{"name":"Transplant-Nephrology Department, University Hospital Martin, Koll\u00e1rova 2, 036 01 Martin, Slovakia"},{"name":"Department of Internal Medicine I, Jessenius Medical Faculty, Comenius University, 036 01 Martin, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3303-2164","authenticated-orcid":false,"given":"T\u00edmea","family":"Blichov\u00e1","sequence":"additional","affiliation":[{"name":"Transplant-Nephrology Department, University Hospital Martin, Koll\u00e1rova 2, 036 01 Martin, Slovakia"},{"name":"Department of Internal Medicine I, Jessenius Medical Faculty, Comenius University, 036 01 Martin, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-1425","authenticated-orcid":false,"given":"Matej","family":"Vnu\u010d\u00e1k","sequence":"additional","affiliation":[{"name":"Transplant-Nephrology Department, University Hospital Martin, Koll\u00e1rova 2, 036 01 Martin, Slovakia"},{"name":"Department of Internal Medicine I, Jessenius Medical Faculty, Comenius University, 036 01 Martin, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-4268","authenticated-orcid":false,"given":"Ivana","family":"Dedinsk\u00e1","sequence":"additional","affiliation":[{"name":"Transplant-Nephrology Department, University Hospital Martin, Koll\u00e1rova 2, 036 01 Martin, Slovakia"},{"name":"Department of Internal Medicine I, Jessenius Medical Faculty, Comenius University, 036 01 Martin, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41572-023-00476-9","article-title":"IgA nephropathy","volume":"9","author":"Stamellou","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1093\/ndt\/gfac004","article-title":"Rapidly progressive IgA nephropathy: Clinicopathological characteristics and outcomes assessed according to the revised definition of the KDIGO 2021 Guideline","volume":"37","author":"Yu","year":"2022","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.kint.2018.02.030","article-title":"Secondary IgA nephropathy","volume":"94","author":"Saha","year":"2018","journal-title":"Kidney Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2023.09.002","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) Lupus Nephritis Work Group. KDIGO 2024 Clinical Practice Guideline for the Management of Lupus Nephritis","volume":"105","author":"Rovin","year":"2024","journal-title":"Kidney Int."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) ANCA Vasculitis Work Group (2024). KDIGO 2024 Clinical Practice Guideline for the Management of Antineutrophil Cytoplasmic Antibody (ANCA)\u2013Associated Vasculitis. Kidney Int. Suppl., 105, S71\u2013S116.","DOI":"10.1016\/j.kint.2023.10.008"},{"key":"ref_6","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group (2012). KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney Int. Suppl., 2, 200\u2013208."},{"key":"ref_7","unstructured":"Musa, R., Rout, P., and Qurie, A. (2020, March 30). 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Nephrol."},{"key":"ref_17","first-page":"e70619","article-title":"Rapidly Progressive Glomerulonephritis Associated with IgA Nephropathy and C3 Deposits in a Patient with Chronic Hepatitis B","volume":"16","author":"Wiese","year":"2024","journal-title":"Cureus"}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/4\/220\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T14:44:08Z","timestamp":1762181048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/8\/4\/220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["reports8040220"],"URL":"https:\/\/doi.org\/10.3390\/reports8040220","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}