{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:38:34Z","timestamp":1766144314608,"version":"3.48.0"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Visual agnosia and speech production deficits are well-described sequelae of neurosurgical interventions, but their selective dissociation remains rare. This report presents an unusual combination of postoperative deficits following awake resection of a left frontal low-grade glioma. Case Presentation: We present the case of a right-handed female with left hemisphere language dominance who had a left frontal low-grade glioma. Preoperatively, she exhibited anomia and dysexecutive syndrome, including difficulty completing everyday goal-directed tasks such as sending emails and paying for parking. Following awake tumor resection, she developed two rare, dissociated deficits: (1) speech restricted to infinitive verb forms and (2) selective visual agnosia for static images, with preserved recognition of dynamic stimuli. Conclusions: This uncommon clinical constellation highlights the vulnerability of left frontal language and ventral visual processing networks during surgery and supports the dual-stream model of vision and language production. We describe a selective form of static visual agnosia affecting static images with relative preservation of dynamic and object recognition, for which we use the descriptive label \u201castatopsia\u201d. This peculiar clinical condition is rarely documented in this particular combination and has not, to the best of our knowledge, previously been denominated in such a manner in the literature.<\/jats:p>","DOI":"10.3390\/reports9010001","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:03:46Z","timestamp":1766142226000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Static Visual Agnosia Following Awake Resection of a Left Frontal Low-Grade Glioma: A Case Report of Ventral Stream Network Disruption (\u201cAstatopsia\u201d)"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7074-8054","authenticated-orcid":false,"given":"Stefano","family":"Vecchioni","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-0704","authenticated-orcid":false,"given":"Alessio","family":"Iacoangeli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy"},{"name":"Department of Neurosurgery, Ospedale IRCSS San Martino, Universit\u00e0 degli Studi di Genova, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bonifazi","sequence":"additional","affiliation":[{"name":"Department of Clinical Health Psychology, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Trignani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Luzi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1093\/brain\/123.12.2512","article-title":"Handedness and hemispheric language dominance in healthy humans","volume":"123","author":"Knecht","year":"2000","journal-title":"Brain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/brain\/110.6.1431","article-title":"A case of integrative visual agnosia","volume":"110","author":"Riddoch","year":"1987","journal-title":"Brain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.psych.53.100901.135220","article-title":"Adult clinical neuropsychology: Lessons from studies of the frontal lobes","volume":"53","author":"Stuss","year":"2002","journal-title":"Annu. Rev. Psychol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0166-2236(92)90344-8","article-title":"Separate visual pathways for perception and action","volume":"15","author":"Goodale","year":"1992","journal-title":"Trends Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e08935","DOI":"10.7554\/eLife.08935","article-title":"Human blindsight is mediated by an intact geniculo-extrastriate pathway","volume":"4","author":"Ajina","year":"2015","journal-title":"eLife"},{"key":"ref_6","unstructured":"Ingle, D.J., Goodale, M.A., and Mansfield, R.J.W. (1982). Two cortical visual systems. Analysis of Visual Behavior, MIT Press."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.neuropsychologia.2016.07.018","article-title":"Visual motion serves but is not under the purview of the dorsal pathway","volume":"89","year":"2016","journal-title":"Neuropsychologia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0022-510X(67)90107-4","article-title":"Course and outcome of visual static agnosia","volume":"4","author":"Botez","year":"1967","journal-title":"J. Neurol. Sci."},{"key":"ref_9","first-page":"1281","article-title":"Intact biological motion and structure from motion perception in a patient with impaired motion mechanisms","volume":"30","author":"Vaina","year":"1990","journal-title":"Vis. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: The Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1037\/h0047762","article-title":"Speech Lateralization in Young Children as Determined by an Auditory Test","volume":"56","author":"Kimura","year":"1963","journal-title":"J. Comp. Physiol. Psychol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1152\/jn.00878.2017","article-title":"Handedness results from complementary hemispheric dominance, not global hemispheric dominance: Evidence from mechanically coupled bilateral movements","volume":"120","author":"Woytowicz","year":"2018","journal-title":"J. Neurophysiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"La Corte, E., Eldahaby, D., Greco, E., Aquino, D., Bertolini, G., Levi, V., Ottenhausen, M., Demichelis, G., Romito, L.M., and Acerbi, F. (2021). The Frontal Aslant Tract: A Systematic Review for Neurosurgical Applications. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.641586"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1523\/JNEUROSCI.3620-10.2011","article-title":"Role of prefrontal cortex in conscious visual perception","volume":"31","author":"Libedinsky","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1212\/WNL.14.12.1101","article-title":"Visual static agnosia with special reference to literal agnosic alexia","volume":"14","author":"Botez","year":"1964","journal-title":"Neurology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0010-9452(79)80067-2","article-title":"Visual agnosia: The dual deficit of perception and recognition","volume":"15","author":"Kertesz","year":"1979","journal-title":"Cortex"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0010-9452(88)80014-5","article-title":"Visual apperceptive agnosia: A clinico-anatomical study of three cases","volume":"24","author":"Warrington","year":"1988","journal-title":"Cortex"},{"key":"ref_18","first-page":"113","article-title":"Associative visual agnosia: A clinico-anatomical study of a single case","volume":"21","author":"Rubens","year":"1971","journal-title":"Neurology"},{"key":"ref_19","unstructured":"Farah, M.J. (1990). Visual Agnosia: Disorders of Object Recognition and What They Tell Us About Normal Vision, MIT Press."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1098\/rstb.1982.0069","article-title":"Neuropsychological studies of object recognition","volume":"298","author":"Warrington","year":"1982","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_21","unstructured":"Ptak, R., Turri, F., and Doganci, N. (2020). Object Recognition and Visual Agnosia. Encyclopedia of Behavioral Neuroscience, Elsevier."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Huberle, E., Gross, C., and Karnath, H.-O. (2012). Perception of biological motion in visual agnosia. Front. Behav. Neurosci., 6.","DOI":"10.3389\/fnbeh.2012.00056"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1523\/JNEUROSCI.5192-08.2009","article-title":"The anatomy of object recognition\u2014Visual form agnosia caused by medial occipitotemporal stroke","volume":"29","author":"Karnath","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1080\/02687038.2012.693584","article-title":"Verb and sentence production and comprehension in aphasia: Northwestern Assessment of Verbs and Sentences (NAVS)","volume":"26","author":"Thompson","year":"2012","journal-title":"Aphasiology"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Faroqi-Shah, Y. (2023). A reconceptualization of sentence production in post-stroke agrammatic aphasia: Beyond morphosyntax. Front. Lang. Sci., 2.","DOI":"10.3389\/flang.2023.1118739"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"478","DOI":"10.38053\/acmj.1708276","article-title":"A systematic review of verb production training in individuals with agrammatic Broca\u2019s aphasia","volume":"7","year":"2025","journal-title":"Anatol. Curr. Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1007\/s00429-014-0863-0","article-title":"Role of fronto-striatal tract and frontal aslant tract in movement and speech: An axonal mapping study","volume":"220","author":"Kinoshita","year":"2015","journal-title":"Brain Struct. 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