{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:43:43Z","timestamp":1770223423997,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Parkinson\u2019s disease (PD) is a neurodegenerative condition characterized by motor and non-motor symptoms, which significantly impact patients\u2019 autonomy and quality of life levels. Basically, the PD diagnosis is clinical and, in some cases, can be challenging to diagnose due to the heterogeneity of the symptoms. Case Presentation: A 58-year-old woman who, during the COVID-19 lockdown, referred to experiences of slight tremor and stiffness in her left hand at rest, but without any other associated symptoms. Firstly, after consulting a general practitioner (GP), the patient was diagnosed with cervical radiculopathy (CR), presented as essential tremor and stiffness to the hand. Nevertheless, during the initial physiotherapy evaluation, the motor symptoms did not fully align with the diagnosis of CR. For this reason, the presence of non-motor symptoms was thoroughly investigated. Notably, hyperhidrosis was identified as a significant non-motor symptom, leading to the patient\u2019s subsequent referral to a neurologist, who finally diagnosed PD. Conclusions: This case report highlights the essential role of physiotherapists in conducting independent assessments and comprehensive investigations of all patients\u2019 symptoms, even when a medical diagnosis has already been established. This is particularly crucial when there is suspicion that musculoskeletal symptoms may be indicative of neurodegenerative diseases such as PD, which is well-known for its extensive array of non-motor symptoms. Especially in women with PD, non-motor symptoms tend to emerge earlier and in a more subtle manner than motor symptoms, making diagnosis challenging. Therefore, meticulous anamnestic data collection is essential, especially by physiotherapists working in direct-access settings.<\/jats:p>","DOI":"10.3390\/reports9010050","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:00:58Z","timestamp":1770109258000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Onset of Parkinson\u2019s Disease Identified Through Hyperhidrosis: A Middle-Aged Woman Case Report"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8673-9123","authenticated-orcid":false,"given":"Mirko","family":"Zitti","sequence":"first","affiliation":[{"name":"Department of Human Neuroscience, University of Rome La Sapienza, 00185 Rome, Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Alma Mater Europea Center of Maribor, 2000 Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8281-4443","authenticated-orcid":false,"given":"Alessandro","family":"Andreani","sequence":"additional","affiliation":[{"name":"Independent Researcher, 19033 Castelnuovo Magra, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1071-2700","authenticated-orcid":false,"given":"Daniele","family":"De Patre","sequence":"additional","affiliation":[{"name":"NeuroRiab Specialist Center for Post-Stroke and Neurological Rehabilitation, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-9253","authenticated-orcid":false,"given":"Luisa","family":"Cacciante","sequence":"additional","affiliation":[{"name":"Laboratory of Healthcare Innovation Technologies, IRCCS San Camillo Hospital, 30126 Venice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-6393","authenticated-orcid":false,"given":"Giorgia","family":"Pregnolato","sequence":"additional","affiliation":[{"name":"Research Ireland Centre Insight, University College Dublin, Dublin 4, D04 V1W8 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s Disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_2","unstructured":"GBD 2016 Parkinson\u2019s Disease Collaborators (2018). 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