{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:36:08Z","timestamp":1770978968386,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: CEUS enhances the visualization of vascular patterns within liver lesions, enabling differentiation between benign and malignant lesions, including hemangiomas, focal nodular hyperplasia, and hepatocellular carcinoma, with high accuracy. Lymphangiomas are rare benign lymphatic-system tumors, with intra-abdominal lymphangiomas accounting for approximately 5% of cases, most of which occur in the pediatric population. Intra-abdominal lymphangiomas commonly occur in multiple localizations due to lymphangiomatosis, but solitary lymphangiomas in adults are rare and easy to be misdiagnosed due to asymptomatic cases or non-specific symptoms. Case Presentation: A 65-year-old male with a history of left nephroadrenalectomy due to clear renal-cell carcinoma and paraaortic lymphadenectomy (staging pT3bN0M0V1R0) presented for a routine contrast-enhanced abdominal computer tomography examination. The scan showed several hypervascular structures that accumulate contrast in the arterial phase in the right liver lobe. Three years later, the patient developed complaints of abdominal pain and night sweats. Multiple MRI and CT examinations were performed, followed by a CEUS and a liver-core biopsy, which supported the diagnosis of hepatic lymphangioma. Conclusions: CEUS may be a more valuable evaluation method for follow-up examination than repeating CT and MRI scans. The real-time diagnostic possibility and tissue-perfusion data provide more profound information about the lesion of interest. Thus, it can be used as a primary diagnostic tool when a biopsy is performed. Although this method is relatively new, it can be applied in clinical settings with great value, and it saves time and resources.<\/jats:p>","DOI":"10.3390\/reports9010059","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:09:19Z","timestamp":1770973759000},"page":"59","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis of a Liver Lymphangioma Using Contrast-Enhanced Ultrasonography (CEUS): Single Case Report"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9307-4853","authenticated-orcid":false,"given":"El\u012bza Marta","family":"Budava","sequence":"first","affiliation":[{"name":"Department of Radiology, Riga Stradins University, LV-1079 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9782-0771","authenticated-orcid":false,"given":"Ieva","family":"P\u016bce","sequence":"additional","affiliation":[{"name":"Department of Radiology, Riga Stradins University, LV-1079 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-7556","authenticated-orcid":false,"given":"Kalvis","family":"Ka\u013cva","sequence":"additional","affiliation":[{"name":"Department of Radiology, Riga Stradins University, LV-1079 Riga, Latvia"},{"name":"Department of Radiology, Riga East Clinical University Hospital, LV-1038 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8255-7392","authenticated-orcid":false,"given":"Nauris","family":"Zdanovskis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Riga Stradins University, LV-1079 Riga, Latvia"},{"name":"Department of Radiology, Riga East Clinical University Hospital, LV-1038 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/a-1610-9171","article-title":"Shear Wave Dispersion Imaging for the Characterization of Focal Liver Lesions\u2014A Pilot study. Scherwellendispersion f\u00fcr die Charakterisierung fokaler Leberl\u00e4sionen\u2014Eine Pilotstudie","volume":"43","author":"Jesper","year":"2022","journal-title":"Ultraschall Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5074571","DOI":"10.1155\/2022\/5074571","article-title":"The Diagnostic Value of Contrast-Enhanced Ultrasound and Enhanced CT Combined with Tumor Markers AFP and CA199 in Liver Cancer","volume":"2022","author":"Kong","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1016\/j.ultrasmedbio.2020.04.030","article-title":"Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS","volume":"46","author":"Dietrich","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00261-011-9788-8","article-title":"Solid focal liver lesions indeterminate by contrast-enhanced CT or MR imaging: The added diagnostic value of contrast-enhanced ultrasound","volume":"37","author":"Quaia","year":"2011","journal-title":"Abdom. Imaging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s00261-017-1402-2","article-title":"Contrast-enhanced ultrasound of benign liver lesions","volume":"43","author":"Zarzour","year":"2017","journal-title":"Abdom. Radiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.12998\/wjcc.v8.i19.4633","article-title":"Solitary hepatic lymphangioma mimicking liver malignancy: A case report and literature review","volume":"8","author":"Long","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.radcr.2020.10.052","article-title":"Intra-abdominal lymphangioma: A case report","volume":"16","author":"Shayesteh","year":"2021","journal-title":"Radiol. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00595-010-4255-7","article-title":"Solitary hepatic lymphangioma: Report of a case","volume":"40","author":"Matsumoto","year":"2010","journal-title":"Surg. Today"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/2193-1801-3-314","article-title":"Solitary hepatic lymphangioma: A one-case report","volume":"3","author":"Liu","year":"2014","journal-title":"Springerplus"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Xiao, J., Shao, Y., and Zhu, S. (2020). Characteristics of adult abdominal cystic Lymphangioma: A single-center Chinese cohort of 12 cases. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01388-8"},{"key":"ref_11","first-page":"5","article-title":"Focal nodular hyperplasia of the liver","volume":"4","author":"Geller","year":"2014","journal-title":"Autops. Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.crad.2007.06.011","article-title":"Focal nodular hyperplasia: Typical and atypical MRI findings with emphasis on the use of contrast media","volume":"63","author":"Marin","year":"2008","journal-title":"Clin. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kaca\u0142a, A., Dorochowicz, M., Matus, I., Pu\u0142a, M., Korbecki, A., Soba\u0144ski, M., Jack\u00f3w-Nowicka, J., Patrza\u0142ek, D., Janczak, D., and Guzi\u0144ski, M. (2024). Hepatic Hemangioma: Review of Imaging and Therapeutic Strategies. Medicina, 60.","DOI":"10.3390\/medicina60030449"},{"key":"ref_14","unstructured":"Shreenath, A.P., Grant, L.M., and Kahloon, A. (2026, January 09). Hepatocellular adenoma, StatPearls, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513264\/."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S399","DOI":"10.1016\/j.jacr.2019.05.022","article-title":"ACR Appropriateness Criteria\u00ae Post-Treatment Follow-up and Active Surveillance of Clinically Localized Renal Cell Cancer","volume":"16","author":"Purysko","year":"2019","journal-title":"J. Am. Coll. Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3350\/kjhep.2012.18.1.101","article-title":"MR imaging of hepatic lymphangioma","volume":"18","author":"Choi","year":"2012","journal-title":"Korean J. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s12072-010-9220-4","article-title":"Giant cystic lymphangioma of the liver","volume":"4","author":"Huang","year":"2010","journal-title":"Hepatol. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.12998\/wjcc.v1.i4.152","article-title":"Rare case of a solitary huge hepatic cystic lymphangioma","volume":"1","author":"Zhang","year":"2013","journal-title":"World J. Clin. Cases"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/01.moo.0000143971.19992.2d","article-title":"Management of lymphatic malformations","volume":"12","author":"Bloom","year":"2004","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"rjaa179","DOI":"10.1093\/jscr\/rjaa179","article-title":"Cystic lymphangioma in adult: A case report and a review of the literature","volume":"2020","author":"Colangeli","year":"2020","journal-title":"J. Surg. Case Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.14366\/usg.21001","article-title":"Contrast-enhanced ultrasonography for the evaluation of malignant focal liver lesions","volume":"41","author":"Chammas","year":"2022","journal-title":"Ultrasonography"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.14701\/kjhbps.2016.20.2.71","article-title":"Case report of solitary giant hepatic lymphangioma","volume":"20","author":"Lee","year":"2016","journal-title":"Korean J. Hepatobiliary Pancreat. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1007\/s00330-022-08988-w","article-title":"The benefit of contrast-enhanced ultrasound in biopsies for focal liver lesions: A retrospective study of 820 cases","volume":"32","author":"Huang","year":"2022","journal-title":"Eur. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Liu, X., Cheng, C., Chen, K., Wu, Y., and Wu, Z. (2021). Recent progress in lymphangioma. Front. Pediatr., 9.","DOI":"10.3389\/fped.2021.735832"}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/1\/59\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:47:01Z","timestamp":1770976021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/1\/59"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["reports9010059"],"URL":"https:\/\/doi.org\/10.3390\/reports9010059","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]}}}