{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:12:22Z","timestamp":1774278742944,"version":"3.50.1"},"reference-count":18,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Scoliosis prevalence in patients with ataxia telangiectasia (AT) is higher than in the general population. Scoliosis monitoring is traditionally performed using X-rays, but radiographic imaging is contraindicated in AT patients due to radiation sensitivity. Current guidelines suggest a diagnostic radiograph with subsequent Magnetic Resonance Imaging (MRI). In this report, we (1) evaluated the feasibility of using surface topography (ST) to observe 3D spine curvature trends in a long-term follow-up of a patient with scoliosis and AT, and (2) developed a novel paradigm for monitoring scoliosis in AT patients. Case presentation: A female patient (11 years old) with AT and scoliosis was monitored using ST in five visits over four years. Between subsequent visits, her ST measurements included average changes in thoracic scoliotic angle of 5.5\u00b0 \u00b1 4.9\u00b0, thoracolumbar scoliotic angle of 7.8\u00b0 \u00b1 5.5\u00b0, thoracic axial surface rotation (ASR) of 8.0\u00b0 \u00b1 8.5\u00b0, thoracolumbar ASR of 7.0\u00b0 \u00b1 4.5\u00b0, thoracic apical deviation of 6 mm (only measured in two visits), thoracolumbar apical deviation of 10 mm \u00b1 2.4 mm, pelvic obliquity of 5.8 mm \u00b1 3.9 mm, shoulder obliquity of 20 mm (only measured in two visits), coronal imbalance of 11.8 mm \u00b1 9.7 mm, and kyphotic angle of 5.5\u00b0 \u00b1 5.4\u00b0. ST effectively monitored curve patterns throughout the 4-year treatment period, enabling informed treatment decisions by the provider, patient, and family. We also developed a novel paradigm combining diagnostic MRI with serial ST imaging every 6\u201312 months to monitor curve progression with supplemental MRI as needed. Conclusions: Our novel ST paradigm provides a feasible method for monitoring 3D scoliosis progression in AT patients while avoiding unnecessary radiographic imaging.<\/jats:p>","DOI":"10.3390\/reports9010093","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:53:34Z","timestamp":1774274014000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Follow-Up for Child with Ataxia Telangiectasia Related Scoliosis Using Surface Topography: A Case Report"],"prefix":"10.3390","volume":"9","author":[{"given":"Brian","family":"Wagner","sequence":"first","affiliation":[{"name":"School of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Thiessen","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA"},{"name":"Department of Orthopaedic Surgery, Children\u2019s Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-0555","authenticated-orcid":false,"given":"Xue-Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA"},{"name":"Department of Orthopaedic Surgery, Children\u2019s Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref_1","first-page":"573","article-title":"The Incidence and Gene Frequency of Ataxia-Telangiectasia in the United States","volume":"39","author":"Swift","year":"1986","journal-title":"Am. J. Hum. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tibs.2006.05.004","article-title":"The ATM-mediated DNA-damage response: Taking shape","volume":"31","author":"Shiloh","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"ref_3","unstructured":"Bhatt, J., Brown, A., Bush, A., Chow, G., Cliffe, L., Corderoy, J., Davies, G., Davies, J., Davis, W., and Kastan, M. (2025, September 30). Ataxia-Telangiectasia in Children: Guidance on Diagnosis and Clinical Care. Available online: https:\/\/atsociety.org.uk\/for-professionals\/health-care-in-a-t\/clinical-guidance-booklet\/."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13023-016-0543-7","article-title":"Ataxia telangiectasia: A review","volume":"11","author":"Wright","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ijrobp.2012.02.018","article-title":"Variation in Telangiectasia Predisposing Genes Is Associated with Overall Radiation Toxicity","volume":"84","author":"Tanteles","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/archpedi.1968.02100020561022","article-title":"Radiation Reaction in Ataxia Telangiectasia","volume":"116","author":"Morgan","year":"1968","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/bmb\/ldm012","article-title":"Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia","volume":"81","author":"Lavin","year":"2007","journal-title":"Br. Med. Bull."},{"key":"ref_8","first-page":"1","article-title":"Ataxia Telangiectasia: A Single Center Experience in a Decade","volume":"2","author":"Mansour","year":"2022","journal-title":"Pediatr. Sci. J."},{"key":"ref_9","first-page":"781","article-title":"Congenital Malformations and Developmental Disabilities in Ataxia-Telangiectasia, Fanconi Anemia, and Xeroderma Pigmentosum Families","volume":"34","author":"Welshimer","year":"1982","journal-title":"Am. J. Hum. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/1874325001206010261","article-title":"Comparison of Radiographic and Surface Topography Measurements in Adolescents with Idiopathic Scoliosis","volume":"6","author":"Frerich","year":"2012","journal-title":"Open Orthop. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/BRS.0000000000001679","article-title":"Validity and Reliability of Spine Rasterstereography in Patients With Adolescent Idiopathic Scoliosis","volume":"42","author":"Hanquinet","year":"2017","journal-title":"Spine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s43390-024-00838-7","article-title":"Correlation of transverse rotation of the spine using surface topography and 3D reconstructive radiography in children with idiopathic scoliosis","volume":"12","author":"Patel","year":"2024","journal-title":"Spine Deform."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1796247","DOI":"10.1155\/2020\/1796247","article-title":"Reliability of the DIERS Formetric 4D Spine Shape Parameters in Adults without Postural Deformities","volume":"2020","author":"Degenhardt","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/BPO.0000000000001943","article-title":"Entire-spine Magnetic Resonance Imaging Findings and Costs in Children with Presumed Adolescent Idiopathic Scoliosis","volume":"41","author":"Johnson","year":"2021","journal-title":"J. Pediatr. Orthop."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1097\/00007632-200009150-00019","article-title":"The Estimated Cost of School Scoliosis Screening","volume":"25","author":"Yawn","year":"2000","journal-title":"Spine"},{"key":"ref_16","unstructured":"(2025, October 26). CPI Inflation Calculator. Bureau of Labor Statistics, Available online: https:\/\/www.bls.gov\/data\/inflation_calculator.htm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/BRS.0000000000002966","article-title":"Limited Sequence MRIs for Early Onset Scoliosis Patients Detected 100% of Neural Axis Abnormalities While Reducing MRI Time by 68%","volume":"44","author":"Murgai","year":"2019","journal-title":"Spine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s00586-015-3960-8","article-title":"EOS microdose protocol for the radiological follow-up of adolescent idiopathic scoliosis","volume":"25","author":"Ilharreborde","year":"2016","journal-title":"Eur. Spine J."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/1\/93\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:24:53Z","timestamp":1774275893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/1\/93"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["reports9010093"],"URL":"https:\/\/doi.org\/10.3390\/reports9010093","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}