{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:37:51Z","timestamp":1774453071883,"version":"3.50.1"},"reference-count":12,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background\/Objectives: This study investigates the relationship between Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), neurophysiological markers assessed via Visual Evoked Potentials (VEPs), and functional capacity. Methods: A total of 190 participants, comprising 95 patients and 95 healthy controls, underwent specialized assessments of VEP latencies and amplitudes (P100 and N145), as well as dominant and non-dominant grip strength. Statistical analyses using independent-samples t-tests and linear regression revealed that patients exhibited significantly prolonged P100 and N145 latencies and reduced P100 amplitudes compared with controls, reflecting impaired neural conduction and heterogeneous fiber involvement. Results: Patients also demonstrated markedly reduced bilateral grip strength, confirming the disease\u2019s impact on gross motor skills and sensorimotor integration. Although gender did not broadly differentiate clinical expression, patients receiving intravenous immunoglobulin (IVIg) therapy showed significant improvements in P100 latency and bilateral grip strength, compared with those not receiving treatment. Conclusions: These findings underscore the utility of VEPs and grip strength as reliable biomarkers for monitoring demyelination and functional status, suggesting that their combined evaluation can enhance clinical management and the assessment of therapeutic response in CIDP.<\/jats:p>","DOI":"10.3390\/reports9020096","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:57:34Z","timestamp":1774447054000},"page":"96","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurophysiological and Functional Assessment in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): The Correlation Between Visual Evoked Potentials and Grip Strength"],"prefix":"10.3390","volume":"9","author":[{"given":"Periklis","family":"Tsoumanis","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, General Hospital of Filiates, 46300 Filiates, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-9274","authenticated-orcid":false,"given":"Dimitrios N.","family":"Varvarousis","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy-Histology-Embryology, Medical School, University of Ioannina, 45500 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-359X","authenticated-orcid":false,"given":"Alexandra","family":"Barbouti","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy-Histology-Embryology, Medical School, University of Ioannina, 45500 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8446-2686","authenticated-orcid":false,"given":"Theocharis","family":"Chatzoglou","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy-Histology-Embryology, Medical School, University of Ioannina, 45500 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Marini","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy-Histology-Embryology, Medical School, University of Ioannina, 45500 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-9485","authenticated-orcid":false,"given":"Christos","family":"Stefanou","sequence":"additional","affiliation":[{"name":"2nd Breast Unit, Department of Surgery, IASO Maternity & Research Hospital, 15123 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Kitsoulis","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy-Histology-Embryology, Medical School, University of Ioannina, 45500 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0140-6736(72)91155-5","article-title":"Delayed visual evoked response in optic neuritis","volume":"299","author":"Halliday","year":"1973","journal-title":"Lancet"},{"key":"ref_2","first-page":"213","article-title":"Pathophysiology of chronic inflammatory demyelinating polyneuropathy: Insights into classification and therapeutic strategy","volume":"9","author":"Misawa","year":"2020","journal-title":"Curr. Opin. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/archneur.63.6.847","article-title":"Multifocal visual evoked potential latency analysis: Predicting progression to multiple sclerosis","volume":"63","author":"Fraser","year":"2006","journal-title":"Arch. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1136\/jnnp-2014-310097","article-title":"Nodopathies of the peripheral nerve: An emerging concept","volume":"86","author":"Uncini","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/00019052-200310000-00007","article-title":"An update on electrophysiological studies in neuropathy","volume":"16","author":"Krarup","year":"2003","journal-title":"Curr. Opin. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/ene.12190","article-title":"Epidemiology of chronic inflammatory neuropathies in southeast England","volume":"21","author":"Hughes","year":"2014","journal-title":"Eur. J. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.clinph.2006.05.016","article-title":"Effects of sex and age on strength-duration properties of peripheral nerve","volume":"117","author":"Yerdelen","year":"2006","journal-title":"Clin. Neurophysiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/jnnp-2011-301882","article-title":"Outcome and its predictors in Guillain-Barr\u00e9 syndrome","volume":"83","author":"Rajabally","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00004691-198401000-00003","article-title":"Evoked potential techniques in the evaluation of visual function","volume":"1","author":"Celesia","year":"1984","journal-title":"J. Clin. Neurophysiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1474-4422(07)70329-0","article-title":"Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): A randomized placebo-controlled trial","volume":"7","author":"Hughes","year":"2008","journal-title":"Lancet Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jns.12455","article-title":"European Academy of Neurology\/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force\u2014Second revision","volume":"26","author":"Hadden","year":"2021","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrneurol.2014.117","article-title":"Diagnosis and treatment of chronic acquired demyelinating polyneuropathies","volume":"10","author":"Latov","year":"2014","journal-title":"Nat. Rev. Neurol."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/2\/96\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:37:29Z","timestamp":1774449449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/2\/96"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["reports9020096"],"URL":"https:\/\/doi.org\/10.3390\/reports9020096","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]}}}