{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:05:45Z","timestamp":1774537545300,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Urachal carcinoma (UrC) is an uncommon neoplasm derived from residual embryonic structures connecting the bladder to the umbilicus. Owing to its rarity, deep anatomic location, and histologic overlap with other glandular malignancies, accurate diagnosis remains challenging. Congenital anomalies of the lower urinary tract, including bladder exstrophy, are recognized as conditions that may predispose to malignant transformation of urachal remnants, although documented cases remain scarce. Case presentation: We describe the case of a 52-year-old male with bladder exstrophy and intellectual disability who presented with a progressively enlarging suprapubic mass and intermittent hematuria. Radiologic evaluation demonstrated a mass arising along the urachal tract. Surgical excision revealed a tumor composed of two morphologically distinct components: an enteric-type adenocarcinoma and a squamous carcinoma. Immunohistochemical profiling indicated urachal derivation and excluded other primary sites. Conclusions: This case expands the morphologic spectrum of UrC and emphasizes the diagnostic value of integrating clinical risk factors with detailed histologic and immunophenotypic assessment, particularly in tumors with mixed differentiation patterns.<\/jats:p>","DOI":"10.3390\/reports9020100","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:50:15Z","timestamp":1774533015000},"page":"100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urachal Carcinoma with Divergent Glandular Enteric-Type and Squamous Differentiation Associated with Bladder Exstrophy: Case Report of an Extremely Rare Entity"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4466-6360","authenticated-orcid":false,"given":"Catalin-Bogdan","family":"Satala","sequence":"first","affiliation":[{"name":"Medical and Pharmaceutical Research Center, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"Department of Pathology, Clinical County Emergency Hospital Braila, 810325 Braila, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Patrichi","sequence":"additional","affiliation":[{"name":"The Doctoral School of Medicine and Pharmacy, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina-Mihaela","family":"Gurau","sequence":"additional","affiliation":[{"name":"The School for Doctoral Studies in Biomedical Sciences, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 800008 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Mihalache","sequence":"additional","affiliation":[{"name":"Medical and Pharmaceutical Research Center, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"Department of Pathology, Clinical County Emergency Hospital Braila, 810325 Braila, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5347(17)50167-6","article-title":"Malignant urachal lesions","volume":"131","author":"Sheldon","year":"1984","journal-title":"J. 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