{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:08:58Z","timestamp":1774973338832,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Burkitt lymphoma is an aggressive form of non-Hodgkin lymphoma of B-cell origin, caused by a MYC gene translocation on chromosome 8. There are three clinical subtypes, of which the sporadic subtype is most prevalent in the United States. Sporadic Burkitt lymphoma is diagnosed at a median age of 30 years and commonly manifests as bulky abdominal lesions, most often involving the ileocecal region. Pancreatic involvement is uncommon, and presentation as acute pancreatitis secondary to Burkitt lymphoma is exceedingly rare. Case Presentation: We present a case of a young male who presented with epigastric pain, nausea, and vomiting. He had a diffusely tender abdomen and elevated lipase levels. On imaging, he was found to have large retroperitoneal and intraperitoneal masses, contiguous with an enlarged pancreas. Burkitt lymphoma was confirmed upon biopsy of duodenal and gastric masses via endoscopic ultrasound. MRI brain and testicular ultrasound revealed unilateral fifth cranial nerve and bilateral testicular involvement, respectively. His course was complicated by bowel perforation requiring urgent surgery. However, he achieved complete remission with dose-dense systemic and intrathecal chemotherapy. Conclusions: This case highlights the diverse presentations of Burkitt\u2019s lymphoma and a favorable prognosis with treatment. Clinicians should maintain a high index of suspicion for a malignant etiology of acute pancreatitis in patients without classic risk factors.<\/jats:p>","DOI":"10.3390\/reports9020103","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:45:53Z","timestamp":1774615553000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aggressive Burkitt Lymphoma Mimicking Acute Pancreatitis: A Case Report"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-6447","authenticated-orcid":false,"given":"Nicole","family":"Sequeira","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6988-6724","authenticated-orcid":false,"given":"Rachael","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0737-4000","authenticated-orcid":false,"given":"Chidambaram","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-6627","authenticated-orcid":false,"given":"Poolakkad S.","family":"Satheeshkumar","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-1888","authenticated-orcid":false,"given":"Kapil","family":"Meleveedu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e70513","DOI":"10.1002\/cam4.70513","article-title":"Prognostic Factors for Survival in Adults With Burkitt Lymphoma: A Systematic Review","volume":"14","author":"Quiros","year":"2025","journal-title":"Cancer Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13244-019-0733-7","article-title":"An update on Burkitt lymphoma: A review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence","volume":"10","author":"Kalisz","year":"2019","journal-title":"Insights Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"152182","DOI":"10.1016\/j.anndiagpath.2023.152182","article-title":"From the archives of MD Anderson Cancer Center: Sporadic Burkitt lymphoma with a complex karyotype and SOX11 expression","volume":"66","author":"Siddiqui","year":"2023","journal-title":"Ann. 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Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1182\/blood-2004-02-0405","article-title":"Adult Burkitt leukemia and lymphoma","volume":"104","author":"Blum","year":"2004","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1016\/S2352-3026(24)00351-X","article-title":"Diagnosis and treatment of Burkitt lymphoma in adults: Clinical practice guidelines from ERN-EuroBloodNet","volume":"12","author":"Ribrag","year":"2025","journal-title":"Lancet Haematol."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/2\/103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:02:24Z","timestamp":1774965744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/2\/103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["reports9020103"],"URL":"https:\/\/doi.org\/10.3390\/reports9020103","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}