{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:37:39Z","timestamp":1777376259690,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Chondroid syringoma is a very rare tumor arising from the sweat glands, with an incidence described in the literature of 0.01% of all primary skin tumors. Case presentation: This paper aims to present the case of a patient treated in our clinic for a large cyst located at the inner corner of the left eye, which appeared two years ago and progressively increased in size. The patient presented for cosmetic reasons and discomfort, especially when wearing glasses. The diagnosis of chondroid syringoma is generally established clinically. The differential diagnosis includes other benign cutaneous lesions (pleomorphic adenoma, lipoma, neurofibroma, a dermoid cyst, dermatofibroma, pleomorphic adenoma of the salivary glands, a sebaceous cyst, or hemangioma) or malignant lesions (basal cell carcinoma, squamous cell carcinoma, or adenocarcinoma). Additional imaging investigations\u2014CT and MRI\u2014are rarely required and would mainly assess the extent of the lesion. Dermoscopy is an early differential diagnostic method, especially for small lesions of 1\u20133 mm, such as xanthelasma, milia, or basal cell carcinoma. Chondroid syringoma may be treated using minimally invasive methods such as fractional CO2 laser, radiofrequency, or electrocautery, but only when the lesion is superficial and small. For larger and deeper tumors, such as in our case, multiple treatment sessions would be required, increasing the cost, and complete removal would not be guaranteed. Conclusions: The chosen treatment is surgical excision with oncologic margins, followed by histopathological and immunohistochemical examination to prevent recurrence and assess the risk of malignancy.<\/jats:p>","DOI":"10.3390\/reports9020136","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:49:36Z","timestamp":1777362576000},"page":"136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chondroid Syringoma of the Inner Corner of the EyeCase Report"],"prefix":"10.3390","volume":"9","author":[{"given":"Alin","family":"Tatu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cLower Danube\u201d University, 800008 Galati, Romania"},{"name":"\u201cSt. Parascheva\u201d Infectious Diseases Hospital, 700116 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiberiu","family":"Tebeica","sequence":"additional","affiliation":[{"name":"Leventer Medical Center, 011864 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9655-6721","authenticated-orcid":false,"given":"Mihaela Denisa","family":"Pirvu","sequence":"additional","affiliation":[{"name":"First Surgery Department, \u201cSt. Andrew\u201d Emergency County Clinical Hospital, 900591 Constanta, Romania"},{"name":"Department of General Surgery, Faculty of Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0181-691X","authenticated-orcid":false,"given":"Cristian Constantin","family":"Popa","sequence":"additional","affiliation":[{"name":"Second Department of General Surgery, University Emergency Hospital, 050098 Bucharest, Romania"},{"name":"Department of General Surgery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-1959","authenticated-orcid":false,"given":"Valeriu","family":"Ardeleanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cLower Danube\u201d University, 800008 Galati, Romania"},{"name":"Department of General Surgery, Plastic Surgery, Faculty of Medicine, \u201cOvidius\u201d University, 900470 Constanta, Romania"},{"name":"\u201cCFR\u201d General Hospital, 800225 Galati, Romania"},{"name":"Arestetic Clinic, 85 Brailei Street, 800306 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kisova, D., Dikov, T., Ivanova, V., Stoyanov, H., and Yordanova, G. 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