{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:06:13Z","timestamp":1779361573929,"version":"3.51.4"},"reference-count":16,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Familial gastric polyposis is a rare condition associated with an increased risk of malignant transformation, particularly in patients with a strong family history of gastrointestinal malignancies. Case Presentation: We report the case of a 46-year-old female presenting with severe epigastric pain, persistent vomiting, and significant weight loss. Endoscopic and histopathological evaluation confirmed diffuse fundic gland polyposis with intestinal metaplasia involving the entire gastric mucosa. Given the extensive disease, pronounced symptoms, and significant familial cancer burden, the patient underwent total gastrectomy with Roux-en-Y esophagojejunostomy. The postoperative course was uneventful, with satisfactory recovery and favorable functional outcomes during follow-up. This case highlights the clinical challenges associated with diffuse symptomatic familial gastric polyposis and underscores the importance of timely surgical intervention in high-risk patients. Conclusions: Due to clinical complexity of such presentations, detailed case descriptions remain important for guiding clinical practice.<\/jats:p>","DOI":"10.3390\/reports9020162","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:29:58Z","timestamp":1779355798000},"page":"162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse Symptomatic Familial Gastric Polyposis Requiring Total Gastrectomy: A Complex Case Report"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8164-0541","authenticated-orcid":false,"given":"Ivan","family":"Pesic","sequence":"first","affiliation":[{"name":"Clinic for Digestive Surgery, University Clinical Center Nis, 18000 Nis, Serbia"},{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0316-7047","authenticated-orcid":false,"given":"Ilija","family":"Golubovic","sequence":"additional","affiliation":[{"name":"Clinic for Digestive Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milorad","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"},{"name":"Clinic for Thoracic Surgery, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4776-879X","authenticated-orcid":false,"given":"Milica","family":"Nestorovic","sequence":"additional","affiliation":[{"name":"Clinic for Digestive Surgery, University Clinical Center Nis, 18000 Nis, Serbia"},{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-6681","authenticated-orcid":false,"given":"Ivan","family":"Ilic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"},{"name":"Center for Pathology, University Clinical Center Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1136\/gutjnl-2018-318126","article-title":"British Society of Gastroenterology guidelines on gastric adenocarcinoma","volume":"68","author":"Banks","year":"2019","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/his.14275","article-title":"The pathology of gastric and duodenal polyps: Current concepts","volume":"78","author":"Kim","year":"2021","journal-title":"Histopathology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.2169\/internalmedicine.1101-22","article-title":"Attenuated Familial Adenomatous Polyposis","volume":"62","author":"Eizuka","year":"2023","journal-title":"Intern. 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Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.6004\/jnccn.2019.0044","article-title":"NCCN Guidelines Insights","volume":"17","author":"Gupta","year":"2019","journal-title":"J. Natl. Compr. Cancar Netw."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1053\/j.gastro.2019.12.003","article-title":"AGA Clinical Practice Guidelines on Management of Gastric Intestinal Metaplasia","volume":"158","author":"Gupta","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/den.13883","article-title":"Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer (second edition)","volume":"33","author":"Ono","year":"2021","journal-title":"Dig. Endosc."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Japanese Gastric Cancer Association (2021). Gastric cancer treatment guidelines 2018. 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