{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:59:27Z","timestamp":1781143167864,"version":"3.54.1"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Hidradenitis suppurativa (HS) is a chronic, debilitating skin disorder that often affects the inframammary fold (IMF). While surgical management, particularly wide local excision (WLE), is the gold standard for severe cases, less is known about the role of breast surgery techniques in treating HS in this area; Case Presentation: This report presents two cases of female patients with bilateral inframammary HS and mammary hypertrophy, both treated with reduction mammaplasty to excise diseased tissue while addressing breast volume and contour. Both patients had experienced inadequate response to medical therapies, including biologic treatments, and presented with distinct clinical features\u2014one with significant asymmetry and active disease, and the other with more scarring and hypertrophic lesions. During follow-up, no recurrence of disease was observed and both patients reported improved breast appearance and satisfaction; Conclusions: These cases underscore the importance of a multidisciplinary approach, with dermatologists and surgeons both playing a key role in the management of this complex condition.<\/jats:p>","DOI":"10.3390\/reports9020177","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:32:46Z","timestamp":1780885966000},"page":"177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Management of Inframammary Hidradenitis Suppurativa with Reduction Mammaplasty Technique: A Report of Two Cases"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3415-2039","authenticated-orcid":false,"given":"Enrico","family":"Caporali","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Hospital Ca\u2019 Foncello, AULSS2 Marca Trevigiana, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-321X","authenticated-orcid":false,"given":"Paolo","family":"Toninello","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hospital Ca\u2019 Foncello, AULSS2 Marca Trevigiana, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Maritan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hospital Ca\u2019 Foncello, AULSS2 Marca Trevigiana, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gatti","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Ca\u2019 Foncello, AULSS2 Marca Trevigiana, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Berna","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hospital Ca\u2019 Foncello, AULSS2 Marca Trevigiana, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1016\/j.bjps.2009.01.084","article-title":"Surgical Management of Hidradenitis Suppurativa in the Sub-Mammary Area","volume":"63","author":"Nakanishi","year":"2010","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/tbj.14005","article-title":"Inframammary Hidradenitis Suppurativa: An Optimal Surgical Approach to a Challenging Region","volume":"26","author":"Shavit","year":"2020","journal-title":"Breast J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Huynh, F.D., Damiani, G., and Bunick, C.G. (2024). Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution. Antibiotics, 13.","DOI":"10.3390\/antibiotics13030268"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1054\/brst.2000.0271","article-title":"Combined Wide Excision and Mastopexy\/Reduction Mammoplasty for Inframammary Hidradenitis: A Novel and Effective Approach","volume":"10","author":"Williams","year":"2001","journal-title":"Breast"},{"key":"ref_5","first-page":"1","article-title":"An Update on Current Clinical Management and Emerging Treatments in Hidradenitis Suppurativa","volume":"29","author":"Miller","year":"2024","journal-title":"Ski. Ther. Lett."},{"key":"ref_6","first-page":"e49390","article-title":"The Pathogenesis and Treatment of Hidradenitis Suppurativa","volume":"15","author":"Agnese","year":"2023","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chu, Y.-L., and Yu, S. (2024). Hidradenitis Suppurativa: An Understanding of Genetic Factors and Treatment. Biomedicines, 12.","DOI":"10.3390\/biomedicines12020338"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s13555-023-01085-w","article-title":"Burden of Hidradenitis Suppurativa: A Systematic Literature Review of Patient Reported Outcomes","volume":"14","author":"Kimball","year":"2024","journal-title":"Dermatol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/jdv.20472","article-title":"European S2k Guidelines for Hidradenitis Suppurativa\/Acne Inversa Part 2: Treatment","volume":"39","author":"Zouboulis","year":"2025","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0140-6736(24)02475-9","article-title":"Hidradenitis Suppurativa","volume":"405","author":"Sabat","year":"2025","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000539264","article-title":"Guidelines How to Integrate Surgery and Targeted Therapy with Biologics for the Treatment of Hidradenitis Suppurativa: Delphi Consensus Statements from an Italian Expert Panel","volume":"240","author":"Offidani","year":"2024","journal-title":"Dermatology"},{"key":"ref_12","first-page":"35","article-title":"Surgical Management of Hidradenitis Suppurativa: A Narrative Review","volume":"15","author":"Chawla","year":"2022","journal-title":"J. Clin. Aesthetic Dermatol."},{"key":"ref_13","first-page":"E94","article-title":"The Surgeon\u2019s Perspective: A Retrospective Study of Wide Local Excisions Taken to Healthy Subcutaneous Fat in the Management of Advanced Hidradenitis Suppurativa","volume":"63","author":"Shavit","year":"2020","journal-title":"Can. J. Surgery. J. Can. Chir."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.jaad.2015.07.044","article-title":"Recurrence of Hidradenitis Suppurativa after Surgical Management: A Systematic Review and Meta-Analysis","volume":"73","author":"Mehdizadeh","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/pde.15319","article-title":"Hidradenitis Suppurativa Presenting as Mammillary Fistula in a Teenage Girl","volume":"40","author":"Barker","year":"2023","journal-title":"Pediatr. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000431175","article-title":"Hidradenitis Suppurativa\/Acne Inversa: Criteria for Diagnosis, Severity Assessment, Classification and Disease Evaluation","volume":"231","author":"Zouboulis","year":"2015","journal-title":"Dermatology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/bmj.294.6570.487","article-title":"Recurrence after Surgical Treatment of Hidradenitis Suppurativa","volume":"294","author":"Harrison","year":"1987","journal-title":"BMJ"},{"key":"ref_18","first-page":"163","article-title":"Intermammary Hidradenitis Suppurativa: A Case Report","volume":"15","author":"Dharmadji","year":"2022","journal-title":"Int. Med. Case Rep. J."},{"key":"ref_19","first-page":"303","article-title":"Boils at Frictional Locations in a Patient with Hidradenitis Suppurativa","volume":"24","author":"Boer","year":"2016","journal-title":"Acta Dermatovenerol. Croat. ADC"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijscr.2018.08.013","article-title":"Presentation and Surgical Management of Hidradenitis Suppurativa of the Breast during Pregnancy: A Case Report","volume":"51","author":"Samuel","year":"2018","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01.SAP.0000070641.63963.75","article-title":"Surgical Management of Hidradenitis Suppurativa of the Nipple\u2013Areolar Complex","volume":"52","author":"Li","year":"2004","journal-title":"Ann. Plast. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00000637-198801000-00013","article-title":"Surgical Management of Severe Mammary Hidradenitis Suppurativa","volume":"20","author":"Moosa","year":"1988","journal-title":"Ann. Plast. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1093\/ced\/llaf308","article-title":"Extracellular Matrix Alterations in Inflammatory Skin Diseases: Emerging Biomarkers and Clinical Implications","volume":"50","author":"Port","year":"2025","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_24","unstructured":"Novartis Pharmaceuticals (2023). COSENTYX (Secukinumab) Injection for Subcutaneous or Intravenous Use [Prescribing Information Online], Novartis Pharmaceuticals. Available online: https:\/\/www.novartis.com\/us-en\/sites\/novartis_us\/files\/cosentyx.pdf."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0140-6736(23)00022-3","article-title":"Secukinumab in Moderate-to-Severe Hidradenitis Suppurativa (SUNSHINE and SUNRISE): Week 16 and Week 52 Results of Two Identical, Multicentre, Randomised, Placebo-Controlled, Double-Blind Phase 3 Trials","volume":"401","author":"Kimball","year":"2023","journal-title":"Lancet"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jaad.2023.04.034","article-title":"Adalimumab in Conjunction with Surgery Compared with Adalimumab Monotherapy for Hidradenitis Suppurativa: A Randomized Controlled Trial in a Real-World Setting","volume":"89","author":"Aarts","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/ijd.13798","article-title":"Longitudinal Observational Study of Hidradenitis Suppurativa: Impact of Surgical Intervention with Adjunctive Biologic Therapy","volume":"57","author":"Shanmugam","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/DSS.0000000000003290","article-title":"Perioperative Management of Biologics: To Have or to Hold","volume":"48","author":"Ederle","year":"2022","journal-title":"Dermatol. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/jamasurg.2021.3655","article-title":"Efficacy and Safety of Adalimumab in Conjunction with Surgery in Moderate to Severe Hidradenitis Suppurativa: The SHARPS Randomized Clinical Trial","volume":"156","author":"Bechara","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s40257-025-00940-0","article-title":"Comprehensive and Updated Algorithm of Hidradenitis Suppurativa Management from the Experts","volume":"26","author":"Dagenet","year":"2025","journal-title":"Am. J. Clin. Dermatol."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/2\/177\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:24:11Z","timestamp":1781141051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/2\/177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["reports9020177"],"URL":"https:\/\/doi.org\/10.3390\/reports9020177","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]}}}