{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:47:12Z","timestamp":1782204432045,"version":"3.54.5"},"reference-count":10,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: Cerebral amyloid angiopathy (CAA) is a neurovascular disorder characterized by the deposition of amyloid beta (A\u03b2) peptides within the walls of small-to-medium-sized cerebral vessels, leading to vascular fragility and an increased risk of lobar intracerebral hemorrhage (ICH), cognitive decline, and recurrent stroke. CAA is an important cause of spontaneous ICH in elderly patients and may be underrecognized, particularly when presenting with acute neurologic symptoms that mimic ischemic stroke. Early identification has significant implications for management, prognosis, and secondary prevention. Case Presentation: An 80-year-old male presented to the emergency department with incoherent speech, rambling, and severe headache concerning for acute stroke. His medical history was notable for a prior cerebrovascular accident, hypertension, diabetes mellitus, benign prostatic hyperplasia, and recent evaluation for dementia-like symptoms. Initial neuroimaging revealed a 3.2 cm intraparenchymal hemorrhage in the left occipital lobe with surrounding edema. Subsequent MRI demonstrated a lobar hemorrhage pattern suggestive of CAA based on imaging findings and clinical context. The patient was admitted to the intensive care unit (ICU) for close neurologic monitoring. He remained hemodynamically stable with no new motor or sensory deficits. Over a three-day hospital course, his speech and visual deficits improved. Blood pressure was carefully controlled, and repeat imaging demonstrated stable hemorrhage without progression. He was diagnosed with probable CAA and discharged home with supportive services. Conclusions: This case highlights the importance of considering cerebral amyloid angiopathy in elderly patients presenting with spontaneous lobar intracerebral hemorrhage and cognitive symptoms. Prompt recognition and appropriate neuroimaging are critical for diagnosis, risk stratification, and guiding management.<\/jats:p>","DOI":"10.3390\/reports9020191","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:25:34Z","timestamp":1781778334000},"page":"191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral Amyloid Angiopathy Presenting as Lobar Intracerebral Hemorrhage with Cognitive Decline in an 80-Year-Old Patient: A Clinicoradiologic Case Report"],"prefix":"10.3390","volume":"9","author":[{"given":"Riana","family":"Tarabocchia","sequence":"first","affiliation":[{"name":"Department of Family Medicine Rowan, Virtua School of Osteopathic Medicine, Stratford, NJ 08084, USA"},{"name":"Holy Name Medical Center, Teaneck, NJ 07666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Javaid","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Rowan, Virtua School of Osteopathic Medicine, Stratford, NJ 08084, USA"},{"name":"Holy Name Medical Center, Teaneck, NJ 07666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4310-7506","authenticated-orcid":false,"given":"Rahul","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Health Informatics, Rutgers\u2014School of Health Professions, Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Balabanian","sequence":"additional","affiliation":[{"name":"Holy Name Medical Center, Teaneck, NJ 07666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Ulloque","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Rowan, Virtua School of Osteopathic Medicine, Stratford, NJ 08084, USA"},{"name":"Holy Name Medical Center, Teaneck, NJ 07666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5853\/jos.2015.17.1.17","article-title":"Cerebral amyloid angiopathy: Emerging concepts","volume":"17","author":"Yamada","year":"2015","journal-title":"J. Stroke"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/ana.22516","article-title":"Cerebral amyloid angiopathy in the elderly","volume":"70","author":"Viswanathan","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jnnp-2011-301308","article-title":"Sporadic cerebral amyloid angiopathy revisited: Recent insights into pathophysiology and clinical spectrum","volume":"83","author":"Charidimou","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/jnnp-2012-303898","article-title":"Genetics of cerebral amyloid angiopathy: Systematic review and meta-analysis","volume":"84","author":"Samarasekera","year":"2013","journal-title":"J. Neurol. Neurosurg. 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Biomedicines, 13.","DOI":"10.3390\/biomedicines13030603"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S1474-4422(22)00208-3","article-title":"The Boston criteria version 2.0 for cerebral amyloid angiopathy: A multicentre, retrospective, MRI-neuropathology diagnostic accuracy study","volume":"21","author":"Charidimou","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.1161\/STR.0000000000000407","article-title":"2022 Guideline for the Management of Patients with Spontaneous Intracerebral Hemorrhage: A Guideline from the American Heart Association\/American Stroke Association","volume":"53","author":"Greenberg","year":"2022","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/17474930251365861","article-title":"Diagnosis and management of cerebral amyloid angiopathy: A scientific statement from the International CAA Association and the World Stroke Organization","volume":"20","author":"Cordonnier","year":"2025","journal-title":"Int. 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