{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:12:32Z","timestamp":1783930352551,"version":"3.55.0"},"reference-count":5,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Metastatic involvement of the male genitourinary tract by lung cancer is exceedingly rare. We report a 56-year-old man with metastatic lung adenocarcinoma (initial stage T3N2M1b) under pembrolizumab, who presented with severe pelvic pain. Pelvic magnetic resonance imaging and computed tomography demonstrated a large mass with an imaging epicentre favouring the left seminal vesicle, involving the prostate and fistulising to the distal rectum, without pelvic ascites or peritoneal disease. A total PSA of 0.81 ng\/mL and a previous negative prostate biopsy made a primary prostatic malignancy less likely. Biopsy of the rectal component revealed a poorly differentiated carcinoma with an immunophenotype (CK7+, TTF-1+, p40\u2212, CDX2\u2212, NKX3.1\u2212, PAX8\u2212) consistent with metastatic adenocarcinoma of pulmonary origin. The patient underwent palliative pelvic radiotherapy, with improvement of pelvic pain; he subsequently developed pneumaturia and faecaluria and died eight months later from disease progression. Seminal vesicle metastasis from lung carcinoma has been reported previously; to our knowledge, however, this is the first report presenting with rectal fistulisation. This case highlights a diagnostically challenging presentation and the need to consider metastatic disease when evaluating atypical seminal vesicle masses in oncological patients.<\/jats:p>","DOI":"10.3390\/reports9030213","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:05:38Z","timestamp":1783325138000},"page":"213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seminal Vesicle Mass Fistulising to the Rectum: A Rare Urological Presentation of Lung Cancer Metastasis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-8621","authenticated-orcid":false,"given":"Margarida","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Urology Department, Hospital Garcia de Orta, 2805-267 Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-6172","authenticated-orcid":false,"given":"Francisco","family":"Vara-Luiz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Garcia de Orta, 2805-267 Almada, Portugal"},{"name":"Aging Lab, Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health and Science, 2829-511 Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa","family":"Moreira","sequence":"additional","affiliation":[{"name":"Urology Department, Hospital Garcia de Orta, 2805-267 Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo","family":"Rosa","sequence":"additional","affiliation":[{"name":"Urology Department, Hospital Garcia de Orta, 2805-267 Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Urology Department, Hospital Garcia de Orta, 2805-267 Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, April 01). Lung Cancer Fact Sheet. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/lung-cancer."},{"key":"ref_2","first-page":"57","article-title":"Metastasis to the ureter as the first manifestation of occult pulmonary adenocarcinoma. Case report and review of the literature","volume":"27","author":"Ciarka","year":"2023","journal-title":"Contemp. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e13770","DOI":"10.1097\/MD.0000000000013770","article-title":"Seminal vesicle metastasis after liver transplantation for hepatocellular carcinoma: A case report","volume":"98","author":"Shen","year":"2019","journal-title":"Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/RLU.0000000000001519","article-title":"18F-FDG PET\/CT of seminal vesicle metastasis from ascending colon adenocarcinoma","volume":"42","author":"Hsu","year":"2017","journal-title":"Clin. Nucl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4103\/0972-3919.159696","article-title":"Seminal vesicle metastasis from carcinoma lung: A very unusual metastatic site detected with 18F-Fluorodeoxyglucose positron emission tomography\/computed tomography","volume":"30","author":"Sharma","year":"2015","journal-title":"Indian J. Nucl. Med."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/3\/213\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:55:33Z","timestamp":1783929333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/3\/213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["reports9030213"],"URL":"https:\/\/doi.org\/10.3390\/reports9030213","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]}}}