{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:45:27Z","timestamp":1785743127155,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background and Clinical Significance: The co-occurrence of Hashimoto thyroiditis (HT), Graves\u2019 disease (GD), and papillary thyroid carcinoma (PTC) is an extremely rare event and offers a unique opportunity to examine how chronic autoimmune thyroid disease may interact with the process of thyroid cancer development. Case Presentation: We present the case of a 42-year-old female with long-standing autoimmune thyroid disorders who developed progressive Graves\u2019-related orbitopathy that did not improve with corticosteroid therapy. Owing to persistent hyperthyroidism and worsening orbital symptoms, she underwent total thyroidectomy. A histopathological examination of the removed thyroid gland surprisingly found PTC developing within a background of chronic autoimmune inflammation. The patient\u2019s postoperative course included stable thyroid hormone replacement, a significant decrease in serum levels of thyroid autoantibodies, and clinical improvement in her orbital symptoms following decompressive surgery, although partial visual impairment persisted. Conclusions: This case highlights how chronic thyroid autoimmunity may create a carcinogenic environment and emphasizes the importance of comprehensive histopathological assessment and multidisciplinary care for patients with complex autoimmune thyroid disease.<\/jats:p>","DOI":"10.3390\/reports9030248","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:17:40Z","timestamp":1785737860000},"page":"248","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent Hashimoto Thyroiditis, Graves\u2019 Disease, and Papillary Thyroid Carcinoma: A Case Report"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-9872","authenticated-orcid":false,"given":"Venera","family":"Berisha-Muharremi","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo"},{"name":"Department of Endocrinology, Clinic of Endocrinology, University Clinical Centre of Kosovo, 10000 Prishtina, Kosovo"},{"name":"Department of Endocrinology, Poliklinika Endomedica, 10000 Prishtina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5216-7848","authenticated-orcid":false,"given":"Alberta","family":"Humolli","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehona","family":"Telaku","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fisnik","family":"Kurshumliu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo"},{"name":"Institute of Anatomic Pathology, University Clinical Centre of Kosovo, 10000 Prishtina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshat","family":"Mati","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo"},{"name":"Institute of Anatomic Pathology, University Clinical Centre of Kosovo, 10000 Prishtina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vargas-Uricoechea, H. (2023). Molecular mechanisms in autoimmune thyroid disease. Cells, 12.","DOI":"10.3390\/cells12060918"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hu, X., Chen, Y., Shen, Y., Tian, R., Sheng, Y., and Que, H. (2022). Global prevalence and epidemiological trends of Hashimoto\u2019s thyroiditis in adults: A systematic review and meta-analysis. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.1020709"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1210\/jc.2012-4309","article-title":"Clinical utility of TSH receptor antibodies","volume":"98","author":"Barbesino","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_4","unstructured":"Pokhrel, B., and Bhusal, K. (2026, June 24). Graves disease, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK448195\/."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wang, B., Shao, X., Song, R., Xu, D., and Zhang, J.A. (2017). The emerging role of epigenetics in autoimmune thyroid diseases. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00396"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101661","DOI":"10.1016\/j.beem.2022.101661","article-title":"Genetics and Epigenetics of Autoimmune Thyroid Diseases: Translational Implications","volume":"37","author":"Lee","year":"2023","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s12020-023-03634-x","article-title":"Transition from Hashimoto Thyroiditis to Graves\u2019s Disease: An Unpredictable Change?","volume":"84","author":"Vassallo","year":"2024","journal-title":"Endocrine"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Song, B., Lin, Z., Feng, C., Zhao, X., and Teng, W. (2023). Global research landscape and trends of papillary thyroid cancer therapy: A bibliometric analysis. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1252389"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s13193-021-01429-y","article-title":"Thyroid cancer: Global burden and trends","volume":"13","author":"Shank","year":"2021","journal-title":"Indian J. Surg. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s44197-025-00354-5","article-title":"Assessing the rise in papillary thyroid cancer incidence: A 38-year Australian study investigating WHO classification influence","volume":"15","author":"Weller","year":"2025","journal-title":"J. Epidemiol. Glob. Health"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Yao, S., and Zhang, H. (2025). Papillary thyroid carcinoma with Hashimoto\u2019s thyroiditis: Impact and correlation. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1512417"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Palella, M., Giustolisi, F.M., Modica Fiascaro, A., Fichera, M., Palmieri, A., Cannarella, R., Calogero, A.E., Ferrante, M., and Fiore, M. (2023). Risk and prognosis of thyroid cancer in patients with Graves\u2019 disease: An umbrella review. Cancers, 15.","DOI":"10.3390\/cancers15102724"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.14740\/wjon1728","article-title":"Autoimmune Thyroid Disease and Differentiated Thyroid Carcinoma: A Review of the Mechanisms That Explain an Intriguing and Exciting Relationship","volume":"15","year":"2024","journal-title":"World J. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ko\u015bciuszko, M., Buczy\u0144ska, A., Kr\u0119towski, A.J., and Pop\u0142awska-Kita, A. (2023). Could Oxidative Stress Play a Role in the Development and Clinical Management of Differentiated Thyroid Cancer?. Cancers, 15.","DOI":"10.3390\/cancers15123182"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e06361","DOI":"10.1002\/ccr3.6361","article-title":"Spectrum of thyroid disease in a single patient: A case of papillary thyroid carcinoma in a patient with Graves\u2019 disease and Hashimoto\u2019s thyroiditis","volume":"10","author":"Patel","year":"2022","journal-title":"Clin. Case Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"G43","DOI":"10.1530\/EJE-21-0479","article-title":"The 2021 European Group on Graves\u2019 Orbitopathy (EUGOGO) Clinical Practice Guidelines for the Medical Management of Graves\u2019 Orbitopathy","volume":"185","author":"Bartalena","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pani, F., Caria, P., Yasuda, Y., Makoto, M., Mariotti, S., Leenhardt, L., Roshanmehr, S., Caturegli, P., and Buffet, C. (2022). The immune landscape of papillary thyroid cancer in the context of autoimmune thyroiditis. Cancers, 14.","DOI":"10.3390\/cancers14174287"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e230055","DOI":"10.1530\/ETJ-23-0055","article-title":"The role of Graves\u2019 disease in the development of thyroid nodules and thyroid cancer","volume":"12","author":"Soares","year":"2023","journal-title":"Eur. Thyroid J."},{"key":"ref_19","first-page":"427","article-title":"Occult thyroid carcinoma. A study of 160 autopsy cases. The first report for the region of Epirus-Greece","volume":"22","author":"Mitselou","year":"2002","journal-title":"Anticancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1200\/JCO.2016.67.7419","article-title":"Prevalence of differentiated thyroid cancer in autopsy studies over six decades: A meta-analysis","volume":"34","author":"Bell","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2169\/internalmedicine.53.1518","article-title":"Graves\u2019 ophthalmopathy: Epidemiology and natural history","volume":"53","author":"Hiromatsu","year":"2014","journal-title":"Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Bartalena, L., Piantanida, E., Gallo, D., Lai, A., and Tanda, M.L. (2020). Epidemiology, natural history, risk factors, and prevention of Graves\u2019 orbitopathy. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.615993"},{"key":"ref_23","first-page":"401","article-title":"Thyroid orbitopathy: An overview with special attention to the role of radiotherapy","volume":"62","year":"2015","journal-title":"Endocrinol. Diabetes Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13044-025-00248-5","article-title":"Predicting visual acuity recovery in orbital decompression surgery for dysthyroid optic neuropathy","volume":"18","author":"Fearington","year":"2025","journal-title":"Thyroid Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e14162","DOI":"10.1097\/MD.0000000000014162","article-title":"Effect of orbital decompression on dysthyroid optic neuropathy: A retrospective case series","volume":"98","author":"Liang","year":"2019","journal-title":"Medicine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s40618-024-02470-8","article-title":"Long-term outcome of Graves\u2019 orbitopathy following treatment with sirolimus","volume":"48","author":"Comi","year":"2025","journal-title":"J. Endocrinol. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e42966","DOI":"10.1097\/MD.0000000000042966","article-title":"Teprotumumab for treating active thyroid eye disease: A meta-analysis","volume":"104","author":"Cong","year":"2025","journal-title":"Medicine"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zong, Y., Qiu, S., Yang, M., Zhang, J., Zou, Y., Jing, Y., Ohno-Matsui, K., and Kamoi, K. (2025). Teprotumumab for Thyroid Eye Disease: Mechanism, Clinical Efficacy, and Current Challenges. Antibodies, 14.","DOI":"10.3390\/antib14030055"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s40265-022-01804-1","article-title":"Teprotumumab: A review in thyroid eye disease","volume":"82","author":"Nie","year":"2022","journal-title":"Drugs"}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/3\/248\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:58:24Z","timestamp":1785740304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/3\/248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["reports9030248"],"URL":"https:\/\/doi.org\/10.3390\/reports9030248","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,1]]}}}