{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:00:44Z","timestamp":1790006444590,"version":"4.0.1"},"reference-count":53,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reports"],"abstract":"<jats:p>Background: Oral potentially malignant disorders (OPMDs) comprise clinically and histologically heterogeneous lesions associated with an increased risk of oral squamous cell carcinoma (OSCC). Histopathological grading of oral epithelial dysplasia (OED) remains central to risk estimation but has limited predictive precision. Podoplanin and selected cancer stem cell (CSC) or stemness-associated markers may capture complementary biological processes involved in progression. Objective: To synthesize evidence on podoplanin and selected CSC or stemness-associated markers as indicators of malignant transformation and risk stratification across a prespecified OPMD spectrum, while distinguishing longitudinal prediction from cross-sectional, diagnostic, and mechanistic evidence. Methods: Three original PubMed searches covered database inception to 13 July 2026. A post hoc recall audit against three key evidence syntheses identified one eligible longitudinal report missed during the initial selection; this report was added by backward citation checking. A broader supplementary sensitivity query was run during revision and reported separately without being merged into the original selection counts. In total, 47 publications were included. Study design, effect measure, threshold provenance, internal validation, and possible cohort overlap were charted and synthesized narratively. Results: Among the biomarkers reviewed, podoplanin had the most developed longitudinal evidence, including a pooled hazard ratio (HR) of 3.72 (95% confidence interval [CI] 2.40\u20135.76) in one meta-analysis. A separate diagnostic-accuracy synthesis reported sensitivity of 78.9% and specificity of 55.0%, corresponding to a positive likelihood ratio (LR+) of 1.75 and a negative likelihood ratio (LR\u2212) of 0.38. Predictive values varied materially with baseline transformation risk. CD133, BMI1, and ABCG2 showed large associations in individual cohorts, but independent replication and external validation were limited. Cross-sectional expression gradients were not treated as evidence of prospective prediction. Conclusions: Within the defined OPMD scope, podoplanin has the most developed longitudinal evidence, but its predictive values are prevalence-dependent and no marker is sufficiently validated for stand-alone clinical use. Prospective multicenter studies should compare prespecified biomarker models with established clinical, histopathological, and molecular predictors and should evaluate calibration, clinical utility, and external validity before management decisions are altered.<\/jats:p>","DOI":"10.3390\/reports9030316","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:12:09Z","timestamp":1789999929000},"page":"316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Podoplanin and Selected Cancer Stem Cell or Stemness-Associated Markers in Oral Epithelial Dysplasia: A Structured Narrative Review of Their Role in Malignant Transformation and Risk Stratification"],"prefix":"10.3390","volume":"9","author":[{"given":"Panagiota","family":"Dimitropoulou","sequence":"first","affiliation":[{"name":"Department of Dentistry, School of Dentistry, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6384-8088","authenticated-orcid":false,"given":"Filippos","family":"Fytros","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Charisi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9057-1900","authenticated-orcid":false,"given":"Amalia","family":"Syrioti","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Spantidakis","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Poulopoulos","sequence":"additional","affiliation":[{"name":"Department of Dentoalveolar Surgery, Surgical Implantology and Radiology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fasoula","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Ahepa University Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-5942","authenticated-orcid":false,"given":"Efstratios","family":"Karagiannidis","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Ahepa University Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6611-7506","authenticated-orcid":false,"given":"Athanasios","family":"Poulopoulos","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-4220","authenticated-orcid":false,"given":"Vasileios","family":"Zisis","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Dentistry, European University Cyprus, Nicosia 2404, Cyprus"},{"name":"Department of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102986","DOI":"10.1016\/j.critrevonc.2020.102986","article-title":"Oral potentially malignant disorders: A scoping review of prognostic biomarkers","volume":"153","author":"Mello","year":"2020","journal-title":"Crit. Rev. Oncol."},{"key":"ref_2","first-page":"415","article-title":"Prognostic biomarkers for malignant progression of oral epithelial dysplasia: An updated systematic review and meta-analysis","volume":"62","author":"Turton","year":"2024","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.1007\/s13277-014-2266-5","article-title":"Podoplanin\u2014A novel marker in oral carcinogenesis","volume":"35","author":"Swain","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/1055-9965.EPI-18-0672","article-title":"Prognostic value of cancer stem cell markers in potentially malignant disorders of oral mucosa: A meta-analysis","volume":"28","author":"Saluja","year":"2019","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3892\/ol.2016.5379","article-title":"ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia","volume":"13","author":"Habiba","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41073-019-0064-8","article-title":"SANRA\u2014A scale for the quality assessment of narrative review articles","volume":"4","author":"Baethge","year":"2019","journal-title":"Res. Integr. Peer Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/odi.13704","article-title":"Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/odi.14378","article-title":"Podoplanin could be a predictive biomarker of the risk of patients with oral leukoplakia to develop oral cancer: A systematic review and meta-analysis","volume":"30","author":"Monteiro","year":"2024","journal-title":"Oral Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1002\/hed.70018","article-title":"Podoplanin expression and the risk of malignant transformation of oral pre-malignant disease: A systematic review and meta-analysis","volume":"47","author":"Briggs","year":"2025","journal-title":"Head Neck"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1111\/odi.13747","article-title":"Tissue biomarkers for predicting the risk of oral cancer in patients diagnosed with oral leukoplakia: A systematic review","volume":"27","author":"Monteiro","year":"2021","journal-title":"Oral Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jop.13632","article-title":"Tissue biomarkers for predicting the risk of oral cancer in patients diagnosed with oral leukoplakia: A systematic review of the past 4 years","volume":"54","author":"Monteiro","year":"2025","journal-title":"J. Oral Pathol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41432-022-0254-y","article-title":"Can tissue biomarkers be used to determine the prognosis of oral leukoplakia lesions with regards to malignant transformation?","volume":"23","author":"Cousins","year":"2022","journal-title":"Evid.-Based Dent."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4103\/0970-9290.138321","article-title":"Expression of podoplanin in oral premalignant and malignant lesions and its potential as a biomarker","volume":"25","author":"Logeswari","year":"2014","journal-title":"Indian J. Dent. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jcms.2018.02.016","article-title":"Podoplanin expression as a predictive marker of dysplasia in oral leukoplakia","volume":"46","author":"Gissi","year":"2018","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1200\/JCO.2007.13.4072","article-title":"Podoplanin: A novel marker for oral cancer risk in patients with oral premalignancy","volume":"26","author":"Kawaguchi","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.oraloncology.2013.02.008","article-title":"Podoplanin expression in oral leukoplakia: Tumorigenic role","volume":"49","author":"Rodrigo","year":"2013","journal-title":"Oral Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Monteiro, L., Amaral, B.D., Delgado, L., Garc\u00eas, F., Salazar, F., Pacheco, J.J., Lopes, C., and Warnakulasuriya, S. (2022). Podoplanin expression independently and jointly with oral epithelial dysplasia grade acts as a potential biomarker of malignant transformation in oral leukoplakia. Biomolecules, 12.","DOI":"10.3390\/biom12050606"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1601-0825.2012.01927.x","article-title":"Podoplanin expression in oral leukoplakia: Prognostic value and clinicopathological implications","volume":"18","author":"Kreppel","year":"2012","journal-title":"Oral Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jcms.2018.12.005","article-title":"Podoplanin expression in oral leukoplakia\u2014A prospective study","volume":"47","author":"Grochau","year":"2019","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e12450","DOI":"10.1111\/jicd.12450","article-title":"Evaluation of SOX2 and podoplanin expression in oral epithelial dysplasia and its correlation with malignant transformation","volume":"10","author":"Verma","year":"2019","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"20781","DOI":"10.1038\/s41598-021-99326-5","article-title":"Expression of p53, p63, podoplanin and Ki-67 in recurring versus non-recurring oral leukoplakia","volume":"11","author":"Sundberg","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.ijom.2022.01.002","article-title":"Proliferative verrucous leukoplakia: A clinicopathological comparative study","volume":"51","author":"Alkan","year":"2022","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/PAI.0000000000000383","article-title":"Immunohistochemical expression of podoplanin in clinical variants of oral leukoplakia and its correlation with epithelial dysplasia","volume":"26","author":"Nayak","year":"2018","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"852","DOI":"10.47391\/JPMA.8277","article-title":"Association of podoplanin expression to histopathological grades of oral epithelial dysplasia and oral squamous cell carcinoma","volume":"74","author":"Shabir","year":"2024","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.oraloncology.2017.07.015","article-title":"Nomogram for risk prediction of malignant transformation in oral leukoplakia patients using combined biomarkers","volume":"72","author":"Zhang","year":"2017","journal-title":"Oral Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1158\/1078-0432.CCR-09-0498","article-title":"\u0394Np63 overexpression, alone and in combination with other biomarkers, predicts the development of oral cancer in patients with leukoplakia","volume":"15","author":"Saintigny","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1600-0714.1998.tb01980.x","article-title":"Expression of CD44s, CD44v5, CD44v6 and CD44v7-8 in betel quid chewing-associated oral premalignant lesions and squamous cell carcinomas in Taiwan","volume":"27","author":"Kuo","year":"1998","journal-title":"J. Oral Pathol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12105-021-01384-8","article-title":"Cancer stem cell markers, CD44 and ALDH1, for assessment of cancer risk in OPMDs and lymph node metastasis in oral squamous cell carcinoma","volume":"16","author":"Dhumal","year":"2022","journal-title":"Head Neck Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.oraloncology.2017.11.003","article-title":"Cancer stem cell and its niche in malignant progression of oral potentially malignant disorders","volume":"75","author":"Surendran","year":"2017","journal-title":"Oral Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sunny, S.P., R, R.D., Hariharan, A., Mukhia, N., Gurudath, S., G, K., Raghavan, S., Kolur, T., Shetty, V., and R, V.B. (2023). CD44-SNA1 integrated cytopathology for delineation of high-grade dysplastic and neoplastic oral lesions. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0291972"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/jop.12678","article-title":"Uncovering the potential of the CD44v\/SYNE1\/miR34a axis in salivary fluids of oral cancer patients","volume":"47","author":"Shah","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41467-023-36691-x","article-title":"Single-cell transcriptome profiling of the stepwise progression of head and neck cancer","volume":"14","author":"Choi","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"838632","DOI":"10.1155\/2014\/838632","article-title":"CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma","volume":"2014","author":"He","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"762","DOI":"10.55519\/JAMC-S4-11864","article-title":"Frequency of CD44 expression in diagnosed cases of oral epithelial dysplasia and squamous cell carcinoma","volume":"35","author":"Momin","year":"2023","journal-title":"J. Ayub Med. Coll. Abbottabad"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Onofrei, B.A., Apostol, D.G.C., Tanas\u0103, M.-G., Baciu, E.-R., Popa, C., Sciuca, A.M., Toader, M.P., and Costan, V.-V. (2025). Immunohistochemical expression of differentiated embryonic chondrocyte 1 and cluster of differentiation 44 in oral potentially malignant disorders. Medicina, 61.","DOI":"10.3390\/medicina61020251"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/cncr.26483","article-title":"Two stem cell markers, ATP-binding cassette G2 subfamily and BMI-1, predict the transformation of oral leukoplakia to cancer: A long-term follow-up study","volume":"118","author":"Liu","year":"2012","journal-title":"Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/ijc.27720","article-title":"Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia","volume":"132","author":"Liu","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.anndiagpath.2013.06.004","article-title":"CD133 expression in oral lichen planus correlated with the risk for progression to oral squamous cell carcinoma","volume":"17","author":"Sun","year":"2013","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/jop.12955","article-title":"Cancer stem cell markers ALDH1 and BMI1 expression in oral erythroplakia revisited: Implication for driving the process of field cancerization","volume":"49","author":"Feng","year":"2020","journal-title":"J. Oral Pathol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1073274820904959","DOI":"10.1177\/1073274820904959","article-title":"Prognostic significance of ALDH1, BMI1, and OCT4 expression in oral epithelial dysplasia and oral squamous cell carcinoma","volume":"27","author":"Rao","year":"2020","journal-title":"Cancer Control"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1002\/hed.27174","article-title":"Significance of nuclear EGFR and ABCG2 expression in malignant transformation of oral potentially malignant disorders","volume":"44","author":"Tarle","year":"2022","journal-title":"Head Neck"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e20190532","DOI":"10.1590\/1678-7757-2019-0532","article-title":"BMI-1 expression increases in oral leukoplakias and correlates with cell proliferation","volume":"28","author":"Klein","year":"2020","journal-title":"J. Appl. Oral Sci."},{"key":"ref_43","first-page":"1391","article-title":"Increased \u0394Np63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma","volume":"39","author":"Matsubara","year":"2011","journal-title":"Int. J. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s10147-011-0358-4","article-title":"Immunohistochemical location of the p75 neurotrophin receptor in oral leukoplakia and oral squamous cell carcinoma","volume":"18","author":"Kiyosue","year":"2013","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/jop.12073","article-title":"Putative cancer stem cell marker expression in oral epithelial dysplasia and squamous cell carcinoma","volume":"42","author":"Abdulmajeed","year":"2013","journal-title":"J. Oral Pathol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/CBM-182009","article-title":"Expression of PIWIL2 in oral cancer and leukoplakia: Prognostic implications and insights from tumors","volume":"26","author":"Wang","year":"2019","journal-title":"Cancer Biomark."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.oooo.2023.03.005","article-title":"Association between epithelial\u2013mesenchymal transition markers, proliferative index, and oral epithelial dysplasia: An immunohistochemical study","volume":"135","author":"Miguel","year":"2023","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5114\/pjp.2024.145818","article-title":"Epithelial mesenchymal transition and cancer stem cell markers in oral epithelial dysplasia and oral squamous cell carcinoma","volume":"75","author":"Tokozlu","year":"2024","journal-title":"Pol. J. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s13577-026-01373-5","article-title":"Transcriptomic landscape of oral potentially malignant disorders: A meta-analysis approach","volume":"39","author":"Vasudevan","year":"2026","journal-title":"Hum. Cell"},{"key":"ref_50","first-page":"CD001829","article-title":"Interventions for treating oral leukoplakia to prevent oral cancer","volume":"7","author":"Lodi","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Quintanilla, M., Montero-Montero, L., Renart, J., and Mart\u00edn-Villar, E. (2019). Podoplanin in inflammation and cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030707"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1158\/1940-6207.CAPR-25-0406","article-title":"Pattern-based p53 and p16 immunohistochemistry as a potential alternative to loss of heterozygosity testing for progression risk of oral epithelial dysplasia","volume":"19","author":"Liu","year":"2026","journal-title":"Cancer Prev. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1158\/1940-6207.CAPR-12-0173","article-title":"Loss of heterozygosity profiles\u2014Validated risk predictors for progression to oral cancer","volume":"5","author":"Zhang","year":"2012","journal-title":"Cancer Prev. Res."}],"container-title":["Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/3\/316\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:07:40Z","timestamp":1790003260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2571-841X\/9\/3\/316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["reports9030316"],"URL":"https:\/\/doi.org\/10.3390\/reports9030316","relation":{},"ISSN":["2571-841X"],"issn-type":[{"value":"2571-841X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]}}}