{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:54:48Z","timestamp":1782323688961,"version":"3.54.5"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T00:00:00Z","timestamp":1363737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Various parts of Piper nigrum, Piper betle and Gnetum gnemon are  used as  food sources by Malaysians. The purpose of this study is to  examine the anti-quorum sensing (anti-QS) properties of P. nigrum, P. betle and G. gnemon extracts. The hexane, chloroform and methanol extracts of these plants were assessed in bioassays involving Pseudomonas aeruginosa PA01, Escherichia coli [pSB401], E. coli [pSB1075] and Chromobacterium violaceum CV026. It was found that the extracts of these three plants have  anti-QS ability. Interestingly, the hexane, chloroform and methanol  extracts from  P. betle showed the most potent anti-QS activity  as judged by the bioassays. Since there is a variety of plants that  serve as food sources in Malaysia that have yet to be tested for   anti-QS activity, future work should focus on identification of these  plants and isolation of the anti-QS compounds.<\/jats:p>","DOI":"10.3390\/s130303975","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T13:23:35Z","timestamp":1363785815000},"page":"3975-3985","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Piper nigrum, Piper betle and Gnetum gnemon- Natural Food Sourcewith Anti-Quorum Sensing Properties"],"prefix":"10.3390","volume":"13","author":[{"given":"Li","family":"Tan","sequence":"first","affiliation":[{"name":"Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Fong","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-1115","authenticated-orcid":false,"given":"Kok-Gan","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.cellbio.21.012704.131001","article-title":"Quorum sensing: Cell-to-cell communication in bacteria","volume":"21","author":"Waters","year":"2005","journal-title":"Annu. 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