{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:16:01Z","timestamp":1791850561929,"version":"4.3.4"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Herein, we report a novel ferrocenyldithiophosphonate functional conducting polymer and its use as an immobilization matrix in amperometric biosensor applications. Initially, 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)amidoferrocenyldithiophosphonate was synthesized and copolymerized with 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)benzenamine at graphite electrodes. The amino groups on the polymer were utilized for covalent attachment of the enzyme glucose oxidase. Besides, ferrocene on the backbone was used as a redox mediator during the electrochemical measurements. Prior to the analytical characterization, optimization studies were carried out. The changes in current signals at +0.45 V were proportional to glucose concentration from 0.5 to 5.0 mM. Finally, the resulting biosensor was applied for glucose analysis in real samples and the data were compared with the spectrophotometric Trinder method.<\/jats:p>","DOI":"10.3390\/s150101389","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T11:28:59Z","timestamp":1421148539000},"page":"1389-1403","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Ferrocene-Functionalized 4-(2,5-Di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline: A Novel Design in Conducting Polymer-Based Electrochemical Biosensors"],"prefix":"10.3390","volume":"15","author":[{"given":"Rukiye","family":"Ayranci","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Art and Science, Pamukkale University, 20070 Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Demirkol","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey"},{"name":"Institute on Drug Abuse, Toxicology and Pharmaceutical Science (BATI), Ege University,  35100 Bornova, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Ak","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Art and Science, Pamukkale University, 20070 Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suna","family":"Timur","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey"},{"name":"Institute on Drug Abuse, Toxicology and Pharmaceutical Science (BATI), Ege University,  35100 Bornova, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1016\/j.electacta.2009.06.091","article-title":"Polyterthiophene\/CNT composite as a cathode material for lithium batteries employing an ionic liquid electrolyte","volume":"54","author":"Sivakkumar","year":"2009","journal-title":"Electrochim. 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