{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:49:01Z","timestamp":1770360541894,"version":"3.49.0"},"reference-count":14,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Laser Assisted in Situ Keratomileusis (LASIK) is a proven treatment method for corneal refractive surgery. Surgically induced higher order optical aberrations were a major reason why the method was only rarely used to treat presbyopia, an age-related near-vision loss. In this study, a novel customization algorithm for designing multifocal ablation patterns, thereby minimizing induced optical aberrations, was used to treat 36 presbyopic subjects. Results showed that most candidates went from poor visual acuity to uncorrected 20\/20 vision or better for near (78%), intermediate (92%), and for distance (86%) vision, six months after surgery. All subjects were at 20\/25 or better for distance and intermediate vision, and a majority (94%) were also better for near vision. Even though further studies are necessary, our results suggest that the employed methodology is a safe, reliable, and predictable refractive surgical treatment for presbyopia.<\/jats:p>","DOI":"10.3390\/s17061367","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T03:19:32Z","timestamp":1497410372000},"page":"1367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Novel Laser Refractive Surgical Treatment for Presbyopia: Optics-Based Customization for Improved Clinical Outcome"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1987-6232","authenticated-orcid":false,"given":"Bojan","family":"Pajic","sequence":"first","affiliation":[{"name":"Eye Clinic Orasis, Swiss Eye Research Foundation, CH-5734 Reinach, Switzerland"},{"name":"Department of Physics, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 4, 21000 Novi Sad, Serbia"},{"name":"Division of Ophthalmology, Department of Clinical Neurosciences, Geneva University Hospitals, CH-1205 Geneva, Switzerland"},{"name":"Faculty of Medicine of the Military Medical academy, University of Defence, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Pajic-Eggspuehler","sequence":"additional","affiliation":[{"name":"Eye Clinic Orasis, Swiss Eye Research Foundation, CH-5734 Reinach, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Mueller","sequence":"additional","affiliation":[{"name":"Eye Clinic Orasis, Swiss Eye Research Foundation, CH-5734 Reinach, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljka","family":"Cvejic","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 4, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0622-9266","authenticated-orcid":false,"given":"Harald","family":"Studer","sequence":"additional","affiliation":[{"name":"Eye Clinic Orasis, Swiss Eye Research Foundation, CH-5734 Reinach, Switzerland"},{"name":"OCTlab, Department of Ophthalmology, University of Basel, CH-4001 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3928\/1081597X-20120612-01","article-title":"Visual outcomes and patient satisfaction after presbyopic lens exchange with a diffractive multifocal intraocular lens","volume":"28","author":"Chang","year":"2012","journal-title":"J. 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Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.ophtha.2007.09.018","article-title":"Monovision in LASIK","volume":"115","author":"Braun","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/S0161-6420(01)00647-9","article-title":"Monovision outcomes in presbyopic individuals after refractive surgery","volume":"108","author":"Jain","year":"2001","journal-title":"Ophthalmology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3928\/1081597X-20120124-02","article-title":"Visual outcomes and safety of small diameter intrastromal refractive inlay for the corneal compensation of presbyopia","volume":"28","author":"Bouzoukis","year":"2012","journal-title":"J. Refract. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.jcrs.2011.01.027","article-title":"Intracorneal inlay to correct presbyopia: Long-term results","volume":"37","author":"Yilmaz","year":"2011","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jcrs.2011.11.051","article-title":"Visual outcomes and corneal changes after intrastromal femtosecond correction of presbyopia","volume":"28","author":"Menassa","year":"2012","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3928\/1081597X-20150727-04","article-title":"Central PresbyLASIK for Hyperopia and Presbyopia Using Micro-monovision With the Technolas 217P Platform and SUPRACOR Algorithm","volume":"31","author":"Saib","year":"2015","journal-title":"J. Refract. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.2147\/OPTH.S102008","article-title":"Femtosecond laser-assisted in situ keratomileusis multifocal ablation profile using a mini-monovision approach for presbyopic patients with hyperopia","volume":"10","author":"Vastardis","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jcrs.2013.03.016","article-title":"Corneal approach to hyperopic presbyopia treatment: Six-month outcomes of a new multifocal excimer laser in situ keratomileusis procedure","volume":"39","author":"Ryan","year":"2013","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0886-3350(88)80063-4","article-title":"Photorefractive keratectomy: A technique for laser refractive surgery","volume":"14","author":"Munnerlyn","year":"1988","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_12","first-page":"1883","article-title":"Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: A prospective, randomized, paired-eye study","volume":"8","author":"Pajic","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3928\/1081-597X-20060501-06","article-title":"Correction of Presbyopia by Technovision Central Multifocal LASIK (PresbyLASIK)","volume":"22","author":"Alio","year":"2006","journal-title":"J. Refract. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3928\/1081597X-20090512-05","article-title":"Presbyopia Treatment by Monocular Peripheral PresbyLASIK","volume":"25","author":"Eppstein","year":"2009","journal-title":"J. Refract. 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