{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:30:15Z","timestamp":1783416615493,"version":"3.54.6"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["FIS2010-19860"],"award-info":[{"award-number":["FIS2010-19860"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["TEC2016-76021-C2-2R"],"award-info":[{"award-number":["TEC2016-76021-C2-2R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["DTS17-00055"],"award-info":[{"award-number":["DTS17-00055"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["DTS15-00238"],"award-info":[{"award-number":["DTS15-00238"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL)","award":["INNVAL 16\/02"],"award-info":[{"award-number":["INNVAL 16\/02"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["(FEDER)"],"award-info":[{"award-number":["(FEDER)"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INNVAL (DAPatOO)","award":["18\/23"],"award-info":[{"award-number":["18\/23"]}]},{"name":"University of Cantabria postdoctoral grant","award":["POS-UC-2018-16"],"award-info":[{"award-number":["POS-UC-2018-16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Defects of the mitral valve complex imply heart malfunction. The chordae tendineae (CTs) are tendinous strands connecting the mitral and tricuspid valve leaflets to the papillary muscles. These CTs are composed of organized, wavy collagen bundles, making them a strongly birefringent material. Disorder of the collagen structure due to different diseases (rheumatic, degenerative) implies the loss or reduction of tissue birefringence able to be characterized with Polarization Sensitive Optical Coherence Tomography (PS-OCT). PS-OCT is used to discriminate healthy from diseased chords, as the latter must be excised and replaced in clinical conventional interventions. PS-OCT allows to quantify birefringence reduction in human CTs affected by degenerative and rheumatic pathologies. This tissue optical property is proposed as a diagnostic marker for the identification of degradation of tendinous chords to guide intraoperative mitral valve surgery.<\/jats:p>","DOI":"10.3390\/s19030543","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T03:40:55Z","timestamp":1548733255000},"page":"543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of Human Pathological Mitral Chordae Tendineae Using Polarization-sensitive Optical Coherence Tomography"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-1269","authenticated-orcid":false,"given":"Eusebio","family":"Real","sequence":"first","affiliation":[{"name":"Photonics Engineering Group, Department TEISA, University of Cantabria, 39005 Santander, Spain"},{"name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Icardo","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Cantabria, 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaspar","family":"Fern\u00e1ndez-Barreras","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Revuelta","sequence":"additional","affiliation":[{"name":"Emeritus Professor of Surgery, University of Cantabria, 39005 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Calvo D\u00edez","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Service, Marqu\u00e9s de Valdecilla University Hospital, 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Pont\u00f3n","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Service, Marqu\u00e9s de Valdecilla University Hospital, 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Service, Marqu\u00e9s de Valdecilla University Hospital, 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-5967","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"L\u00f3pez Higuera","sequence":"additional","affiliation":[{"name":"Photonics Engineering Group, Department TEISA, University of Cantabria, 39005 Santander, Spain"},{"name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), 39011 Santander, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red - Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2471-3051","authenticated-orcid":false,"given":"Olga Mar\u00eda","family":"Conde","sequence":"additional","affiliation":[{"name":"Photonics Engineering Group, Department TEISA, University of Cantabria, 39005 Santander, Spain"},{"name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL), 39011 Santander, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red - Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"ref_1","first-page":"230","article-title":"Mitral valve repair versus replacement","volume":"4","author":"Mick","year":"2015","journal-title":"Ann. 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