{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:32:10Z","timestamp":1772271130224,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005982","name":"Politechnika Wroc\u0142awska","doi-asserted-by":"publisher","award":["0401\/0023\/18"],"award-info":[{"award-number":["0401\/0023\/18"]}],"id":[{"id":"10.13039\/501100005982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this study, we presented the concept and implementation of a fully functional system for the recognition of bi-heterocyclic compounds. We have conducted research into the application of machine learning methods to correctly recognize compounds based on THz spectra, and we have described the process of selecting optimal parameters for the kernel support vector machine (KSVM) with an additional \u2018unknown\u2019 class. The chemical compounds used in the study contain a target molecule, used in pharmacy to combat inflammatory states formed in living organisms. Ready-made medical products with similar properties are commonly referred to as non-steroidal anti-inflammatory drugs (NSAIDs) once authorised on the pharmaceutical market. It was crucial to clearly determine whether the tested sample is a chemical compound known to researchers or is a completely new structure which should be additionally tested using other spectrometric methods. Our approach allows us to achieve 100% accuracy of the classification of the tested chemical compounds in the time of several milliseconds counted for 30 samples of the test set. It fits perfectly into the concept of rapid recognition of bi-heterocyclic compounds without the need to analyse the percentage composition of compound components, assuming that the sample is classified in a known group. The method allows us to minimize testing costs and significant reduction of the time of analysis.<\/jats:p>","DOI":"10.3390\/s19153349","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T11:15:56Z","timestamp":1564485356000},"page":"3349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recognition of Pharmacological Bi-Heterocyclic Compounds by Using Terahertz Time Domain Spectroscopy and Chemometrics"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-4867","authenticated-orcid":false,"given":"Maciej Roman","family":"Nowak","sequence":"first","affiliation":[{"name":"Faculty of Electronics, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-6717","authenticated-orcid":false,"given":"Rafa\u0142","family":"Zdunek","sequence":"additional","affiliation":[{"name":"Faculty of Electronics, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-8036","authenticated-orcid":false,"given":"Edward","family":"Pli\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Electronics, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3676-2341","authenticated-orcid":false,"given":"Piotr","family":"\u015awi\u0105tek","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Drugs, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw Ludwika Pasteura 1, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2425-764X","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Strzelecka","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Drugs, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw Ludwika Pasteura 1, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7983-9447","authenticated-orcid":false,"given":"Wies\u0142aw","family":"Malinka","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Drugs, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw Ludwika Pasteura 1, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142awa","family":"Pli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw Ludwika Pasteura 1, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"key":"ref_1","unstructured":"Eicher, T., Hauptmann, S., and Speicher, A. 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