{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:48:33Z","timestamp":1791254913138,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Surface-enhanced Raman spectroscopy (SERS) technology is an attractive method for the prompt and accurate on-site screening of illicit drugs. As portable Raman systems are available for on-site screening, the readiness of SERS technology for sensing applications is predominantly dependent on the accuracy, stability and cost-effectiveness of the SERS strip. An atmospheric-pressure plasma-assisted chemical deposition process that can deposit an even distribution of nanogold particles in a one-step process has been developed. The process was used to print a nanogold film on a paper-based substrate using a HAuCl4 solution precursor. X-ray photoelectron spectroscopy (XPS) analysis demonstrates that the gold has been fully reduced and that subsequent plasma post-treatment decreases the carbon content of the film. Results for cocaine detection using this substrate were compared with two commercial SERS substrates, one based on nanogold on paper and the currently available best commercial SERS substrate based on an Ag pillar structure. A larger number of bands associated with cocaine was detected using the plasma-printed substrate than the commercial substrates across a range of cocaine concentrations from 1 to 5000 ng\/mL. A detection limit as low as 1 ng\/mL cocaine with high spatial uniformity was demonstrated with the plasma-printed substrate. It is shown that the plasma-printed substrate can be produced at a much lower cost than the price of the commercial substrate.<\/jats:p>","DOI":"10.3390\/s21030810","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T08:29:16Z","timestamp":1611649756000},"page":"810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Application of Plasma-Printed Paper-Based SERS Substrate for Cocaine Detection"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1619-1636","authenticated-orcid":false,"given":"Rhiannon","family":"Alder","sequence":"first","affiliation":[{"name":"Centre for Forensic Science, University of Technology Sydney, Sydney, NSW 2007, Australia"},{"name":"IDEAL ARC Research Hub, University of Technology Sydney, Sydney, NSW 2007, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6998-9502","authenticated-orcid":false,"given":"Jungmi","family":"Hong","sequence":"additional","affiliation":[{"name":"CSIRO Manufacturing, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-3810","authenticated-orcid":false,"given":"Edith","family":"Chow","sequence":"additional","affiliation":[{"name":"CSIRO Manufacturing, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Fang","sequence":"additional","affiliation":[{"name":"Aloxitec Pty Ltd., Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-7242","authenticated-orcid":false,"given":"Fabio","family":"Isa","sequence":"additional","affiliation":[{"name":"CSIRO Manufacturing, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-0397","authenticated-orcid":false,"given":"Bryony","family":"Ashford","sequence":"additional","affiliation":[{"name":"CSIRO Manufacturing, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Comte","sequence":"additional","affiliation":[{"name":"CSIRO Manufacturing, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Bendavid","sequence":"additional","affiliation":[{"name":"CSIRO Manufacturing, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Xiao","sequence":"additional","affiliation":[{"name":"Centre for Forensic Science, University of Technology Sydney, Sydney, NSW 2007, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostya (Ken)","family":"Ostrikov","sequence":"additional","affiliation":[{"name":"School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4001, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-3612","authenticated-orcid":false,"given":"Shanlin","family":"Fu","sequence":"additional","affiliation":[{"name":"Centre for Forensic Science, University of Technology Sydney, Sydney, NSW 2007, Australia"},{"name":"IDEAL ARC Research Hub, University of Technology Sydney, Sydney, NSW 2007, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-2304","authenticated-orcid":false,"given":"Anthony B.","family":"Murphy","sequence":"additional","affiliation":[{"name":"CSIRO Manufacturing, Lindfield, NSW 2070, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12678","DOI":"10.1021\/acs.analchem.8b02909","article-title":"Detection and quantitation of trace fentanyl in heroin by surface-enhanced raman spectroscopy","volume":"90","author":"Haddad","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/jrs.5220","article-title":"SERS, Raman, and DFT analyses of fentanyl and carfentanil: Toward detection of trace samples","volume":"48","author":"Leonard","year":"2017","journal-title":"J. Raman Spectrosc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/jrs.4864","article-title":"Raman spectroscopy in forensic analysis: Identification of cocaine and other illegal drugs of abuse","volume":"47","author":"Pacheco","year":"2016","journal-title":"J. Raman Spectrosc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.1021\/nn402563f","article-title":"Rapid detection of drugs of abuse in saliva using surface enhanced raman spectroscopy and microfluidics","volume":"7","author":"Andreou","year":"2013","journal-title":"ACS Nano"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1556-4029.2010.01562.x","article-title":"Surface-Enhanced raman spectroscopy for trace identification of controlled substances: Morphine, codeine, and hydrocodone","volume":"56","author":"Rana","year":"2011","journal-title":"J. Forensic Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/jrs.4203","article-title":"Trace level detection and identification of nitro-based explosives by surface-enhanced Raman spectroscopy","volume":"44","author":"Botti","year":"2013","journal-title":"J. Raman Spectrosc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1021\/acssensors.6b00749","article-title":"Hand-Held femtogram detection of hazardous picric acid with hydrophobic Ag nanopillar SERS substrates and mechanism of elasto-capillarity","volume":"2","author":"Hakonen","year":"2017","journal-title":"ACS Sens."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/cphc.200900867","article-title":"Novel bottom-up SERS substrates for quantitative and parallelized analytics","volume":"11","author":"Strelau","year":"2010","journal-title":"ChemPhysChem"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1103\/RevModPhys.57.783","article-title":"Surface-Enhanced spectroscopy","volume":"57","author":"Moskovits","year":"1985","journal-title":"Rev. Mod. Phys."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"116326","DOI":"10.1016\/j.ijms.2020.116326","article-title":"Raman spectroscopy coupled with ambient ionization mass spectrometry: A forensic laboratory investigation into rapid and simple dual instrumental analysis techniques","volume":"452","author":"Fedick","year":"2020","journal-title":"Int. J. Mass Spectrom."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1039\/c3an00673e","article-title":"Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates","volume":"138","author":"Yu","year":"2013","journal-title":"Analyst"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.1039\/C6TB01046F","article-title":"Gold nanoflowers with tunable sheet-like petals: Facile synthesis, SERS performances and cell imaging","volume":"4","author":"Song","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16264","DOI":"10.1039\/C6RA28450G","article-title":"Optimizing the SERS enhancement of a facile gold nanostar immobilized paper-based SERS substrate","volume":"7","author":"He","year":"2017","journal-title":"RSC Adv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"25601","DOI":"10.1039\/C4CP04017A","article-title":"Controllable synthesis and SERS characteristics of hollow sea-urchin gold nanoparticles","volume":"16","author":"Li","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1039\/C4NR06429A","article-title":"Plasmonic core-shell nanoparticles for SERS detection of the pesticide thiram: Size- and shape-dependent Raman enhancement","volume":"7","author":"Guo","year":"2015","journal-title":"Nanoscale"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1063\/1.1571979","article-title":"Optimized surface-enhanced Raman scattering on gold nanoparticle arrays","volume":"82","author":"Felidj","year":"2003","journal-title":"Appl. Phys. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1021\/acsami.6b14008","article-title":"Design of hybrid nanostructural arrays to manipulate SERS-Active substrates by nanosphere lithography","volume":"9","author":"Zhao","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.snb.2013.01.035","article-title":"Focused-ion-beam-fabricated Au\/Ag multilayered nanorod array as SERS-active substrate for virus strain detection","volume":"181","author":"Sivashanmugan","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8190","DOI":"10.1021\/acsomega.8b01318","article-title":"Ag\/Au nanoparticle-loaded paper-based versatile surface-enhanced raman spectroscopy substrates for multiple explosives detection","volume":"3","author":"Moram","year":"2018","journal-title":"ACS Omega"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1039\/c3ra00102d","article-title":"Sintered gold nanoparticles as an electrode material for paper-based electrochemical sensors","volume":"3","author":"Liana","year":"2013","journal-title":"RSC Adv."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Marques, A., Veigas, B., Araujo, A., Pagara, B., Baptista, P.V., Aguas, H., Martins, R., and Fortunato, E. (2019). Paper-Based SERS platform for one-step screening of tetracycline in milk. Sci. Rep. UK, 9.","DOI":"10.1038\/s41598-019-54380-y"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"68545","DOI":"10.1039\/C6RA07280A","article-title":"Paper-based SERS active substrates on demand","volume":"6","author":"Joshi","year":"2016","journal-title":"RSC Adv."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lee, D.J., and Kim, D.Y. (2019). Hydrophobic paper-based SERS sensor using gold nanoparticles arranged on graphene oxide flakes. Sensors, 19.","DOI":"10.3390\/s19245471"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1021\/am1009875","article-title":"Paper-Based SERS swab for rapid trace detection on real-world surfaces","volume":"2","author":"Lee","year":"2010","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1039\/C2AN36116G","article-title":"Inkjet-printed paper-based SERS dipsticks and swabs for trace chemical detection","volume":"138","author":"Yu","year":"2013","journal-title":"Analyst"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9626","DOI":"10.1021\/ac102475k","article-title":"Inkjet printed surface enhanced raman spectroscopy array on cellulose paper","volume":"82","author":"Yu","year":"2010","journal-title":"Anal. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Restaino, S.M., and White, I.M. (2016). Inkjet-Printed paper surface enhanced Raman spectroscopy (SERS) sensors Portable, low cost diagnostics for microRNA. IEEE Sens., 1\u20133.","DOI":"10.1109\/ICSENS.2016.7808421"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hoppmann, E.P., Yu, W.W., and White, I.M. (2014). Inkjet-Printed fluidic paper devices for chemical and biological analytics using surface enhanced raman spectroscopy. IEEE J. Sel. Top. Quantum, 20.","DOI":"10.1109\/JSTQE.2013.2286076"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ymeth.2013.07.010","article-title":"Highly sensitive and flexible inkjet printed SERS sensors on paper","volume":"63","author":"Hoppmann","year":"2013","journal-title":"Methods"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1039\/C9TC01808E","article-title":"Direct plasma printing of nano-gold from an inorganic precursor","volume":"7","author":"Hong","year":"2019","journal-title":"J. Mater. Chem. C"},{"key":"ref_31","unstructured":"Australian Criminal Intelligence Commission (2019). National Wastewater Drug Monitoring Program\u2014Report 6."},{"key":"ref_32","unstructured":"Australian Criminal Intelligence Commission (2019). Illicit Drug Data Report 2017\u20132018."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fncir.2013.00152","article-title":"Dopamine signaling in reward-related behaviors","volume":"7","author":"Baik","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"ref_34","unstructured":"Brands, B., Sproule, B., and Marshman, J. (1998). Drugs & Drug Abuse, Centre for Addiction and Mental Health. [3rd ed.]."},{"key":"ref_35","unstructured":"Brunton, L., Knollman, B., and Chabner, B. (2011). Goodman & Gilman\u2019s: The Pharmacological Basis of Therapeutics, McGraw-Hill Medical."},{"key":"ref_36","unstructured":"Julien, R.M., Advokat, C.D., and Comaty, J.E. (2010). Primer of Drug Action, Worth Publishers."},{"key":"ref_37","unstructured":"Baldock, M.R.J., and Wooley, J.E. (2013, January 28\u201330). Reviews of the effectiveness of random drug testing in Australia: The absence of crash-based evaluations. Proceedings of the Australasian Road Safety Research, Policing & Education Conference, Brisbane, Australia."},{"key":"ref_38","unstructured":"Alder, R., Xiao, L.D., and Fu, S.L. (2020). Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine. Drug Test. Anal., 1\u20139."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/chromsci\/35.7.321","article-title":"Liquid chromatographic determination of cocaine, benzoylecgonine, and cocaethylene in whole blood and serum samples with diode-array detection","volume":"35","author":"Clauwaert","year":"1997","journal-title":"J. Chromatogr. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"99654","DOI":"10.1039\/C5RA21669A","article-title":"Ultrafast synthesis of continuous Au thin films from chloroauric acid solution using an atmospheric pressure plasma jet","volume":"5","author":"Wu","year":"2015","journal-title":"RSC Adv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1021\/acs.nanolett.6b03440","article-title":"Continuous in-flight synthesis for on-demand delivery of ligand-free colloidal gold nanoparticles","volume":"17","author":"Maguire","year":"2017","journal-title":"Nano Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0008-6223(02)00270-1","article-title":"Oxygen plasma modification of pitch-based isotropic carbon fibres","volume":"41","author":"Boudou","year":"2003","journal-title":"Carbon"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kan, C.W., and Man, W.S. (2018). Surface characterisation of atmospheric pressure plasma treated cotton fabric-effect of operation parameters. Polymers, 10.","DOI":"10.3390\/polym10030250"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/3\/810\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:15:26Z","timestamp":1760159726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/3\/810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["s21030810"],"URL":"https:\/\/doi.org\/10.3390\/s21030810","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,26]]}}}